Publication Date:
1992-07-24
Description:
A t(17;19) chromosomal translocation in early B-lineage acute leukemia was shown to result in chimeric transcripts that contain sequences from the E2A basic helix-loop-helix transcription factor gene on chromosome 19, fused to sequences from a previously unidentified gene (HLF) on chromosome 17 that encodes a hepatic leukemia factor. The chimeric protein consisted of the amino-terminal transactivation domain of E2A linked to the carboxyl-terminal basic region-leucine zipper domain of HLF. HLF was normally expressed in liver and kidney, but not in lymphoid cells, and was found to be closely related to the leucine zipper-containing transcription factors DBP (albumin D-box binding protein) and TEF (thyrotroph embryonic factor), which regulate developmental stage-specific gene expression.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Inaba, T -- Roberts, W M -- Shapiro, L H -- Jolly, K W -- Raimondi, S C -- Smith, S D -- Look, A T -- CA-20180/CA/NCI NIH HHS/ -- CA-21765/CA/NCI NIH HHS/ -- CA-42804/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1992 Jul 24;257(5069):531-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Hematology-Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1386162" target="_blank"〉PubMed〈/a〉
Keywords:
Adenovirus Early Proteins
;
Amino Acid Sequence
;
Base Sequence
;
Blotting, Northern
;
Burkitt Lymphoma/*genetics
;
Cell Line
;
*Chromosomes, Human, Pair 17
;
*Chromosomes, Human, Pair 19
;
Cloning, Molecular
;
Humans
;
Leucine Zippers/*genetics
;
Molecular Sequence Data
;
*Multigene Family
;
Oligodeoxyribonucleotides
;
Oncogene Proteins, Viral/*genetics
;
Polymerase Chain Reaction/methods
;
RNA, Neoplasm/genetics/isolation & purification
;
Restriction Mapping
;
Sequence Homology, Nucleic Acid
;
Transcription Factors/*genetics
;
*Translocation, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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