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  • 1
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    JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin (2009)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2009-09-29
    Description: Activation of Janus kinase 2 (JAK2) by chromosomal translocations or point mutations is a frequent event in haematological malignancies. JAK2 is a non-receptor tyrosine kinase that regulates several cellular processes by inducing cytoplasmic signalling cascades. Here we show that human JAK2 is present in the nucleus of haematopoietic cells and directly phosphorylates Tyr 41 (Y41) on histone H3. Heterochromatin protein 1alpha (HP1alpha), but not HP1beta, specifically binds to this region of H3 through its chromo-shadow domain. Phosphorylation of H3Y41 by JAK2 prevents this binding. Inhibition of JAK2 activity in human leukaemic cells decreases both the expression of the haematopoietic oncogene lmo2 and the phosphorylation of H3Y41 at its promoter, while simultaneously increasing the binding of HP1alpha at the same site. Tauhese results identify a previously unrecognized nuclear role for JAK2 in the phosphorylation of H3Y41 and reveal a direct mechanistic link between two genes, jak2 and lmo2, involved in normal haematopoiesis and leukaemia.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785147/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785147/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dawson, Mark A -- Bannister, Andrew J -- Gottgens, Berthold -- Foster, Samuel D -- Bartke, Till -- Green, Anthony R -- Kouzarides, Tony -- 089957/Wellcome Trust/United Kingdom -- 12765/Cancer Research UK/United Kingdom -- G0800784/Medical Research Council/United Kingdom -- MC_UP_1102/2/Medical Research Council/United Kingdom -- Cancer Research UK/United Kingdom -- Medical Research Council/United Kingdom -- Wellcome Trust/United Kingdom -- England -- Nature. 2009 Oct 8;461(7265):819-22. doi: 10.1038/nature08448. Epub 2009 Sep 27.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cambridge Institute for Medical Research and Department of Haematology, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19783980" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptor Proteins, Signal Transducing ; Animals ; Binding Sites ; Cell Line ; Cell Nucleus/enzymology ; Chromatin/chemistry/*metabolism ; Chromosomal Proteins, Non-Histone/*metabolism ; DNA-Binding Proteins/genetics ; Gene Expression Regulation, Neoplastic ; Hematopoiesis/genetics ; Hematopoietic Stem Cells/cytology/enzymology ; Histones/chemistry/genetics/*metabolism ; Humans ; Janus Kinase 2/antagonists & inhibitors/*metabolism ; LIM Domain Proteins ; Leukemia/enzymology/genetics/metabolism/pathology ; Metalloproteins/genetics ; Mice ; Oncogenes/genetics ; Phosphorylation ; Promoter Regions, Genetic/genetics ; Protein Binding ; Proto-Oncogene Proteins ; Signal Transduction ; Tyrosine/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 2
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    Groundwater quality and depletion in the Indo-Gangetic Basin mapped from in situ observations (2016)
    Springer Nature
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    Publication Date: 2016-10-01
    Description: Nature Geoscience 9, 762 (2016). doi:10.1038/ngeo2791 Authors: A. M. MacDonald, H. C. Bonsor, K. M. Ahmed, W. G. Burgess, M. Basharat, R. C. Calow, A. Dixit, S. S. D. Foster, K. Gopal, D. J. Lapworth, R. M. Lark, M. Moench, A. Mukherjee, M. S. Rao, M. Shamsudduha, L. Smith, R. G. Taylor, J. Tucker, F. van Steenbergen & S. K. Yadav Groundwater abstraction from the transboundary Indo-Gangetic Basin comprises 25% of global groundwater withdrawals, sustaining agricultural productivity in Pakistan, India, Nepal and Bangladesh. Recent interpretations of satellite gravity data indicate that current abstraction is unsustainable, yet these large-scale interpretations lack the spatio-temporal resolution required to govern groundwater effectively. Here we report new evidence from high-resolution in situ records of groundwater levels, abstraction and groundwater quality, which reveal that sustainable groundwater supplies are constrained more by extensive contamination than depletion. We estimate the volume of groundwater to 200 m depth to be 〉20 times the combined annual flow of the Indus, Brahmaputra and Ganges, and show the water table has been stable or rising across 70% of the aquifer between 2000 and 2012. Groundwater levels are falling in the remaining 30%, amounting to a net annual depletion of 8.0 ± 3.0 km3. Within 60% of the aquifer, access to potable groundwater is restricted by excessive salinity or arsenic. Recent groundwater depletion in northern India and Pakistan has occurred within a longer history of groundwater accumulation from extensive canal leakage. This basin-wide synthesis of in situ groundwater observations provides the spatial detail essential for policy development, and the historical context to help evaluate recent satellite gravity data.
    Print ISSN: 1752-0894
    Electronic ISSN: 1752-0908
    Topics: Geosciences
    Published by Springer Nature
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  • 3
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    Order selection in finite mixture models: complete or observed likelihood information criteria? (2015)
    Oxford University Press
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    Publication Date: 2015-08-21
    Description: Choosing the number of components in a finite mixture model is a challenging task. In this article, we study the behaviour of information criteria for selecting the mixture order, based on either the observed likelihood or the complete likelihood including component labels. We propose a new observed likelihood criterion called aic mix , which is shown to be order consistent. We further show that when there is a nontrivial level of classification uncertainty in the true model, complete likelihood criteria asymptotically underestimate the true number of components. A simulation study illustrates the potentially poor finite-sample performance of complete likelihood criteria, while aic mix and the Bayesian information criterion perform strongly regardless of the level of classification uncertainty.
    Print ISSN: 0006-3444
    Electronic ISSN: 1464-3510
    Topics: Biology , Mathematics , Medicine
    Published by Oxford University Press
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  • 4
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    BPS sectors of the Skyrme model and their non-BPS extensions (2018)
    American Physical Society (APS)
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    Publication Date: 2018-02-10
    Description: Author(s): C. Adam, D. Foster, S. Krusch, and A. Wereszczynski Two recently found coupled Bogomol’nyi-Prasad-Sommerfield (BPS) submodels of the Skyrme model are further analyzed. First, we provide a geometrical formulation of the submodels in terms of the eigenvalues of the strain tensor. Second, we study their thermodynamical properties and show that the mean-... [Phys. Rev. D 97, 036002] Published Fri Feb 09, 2018
    Keywords: Phenomenological aspects of field theory, general methods
    Print ISSN: 0556-2821
    Electronic ISSN: 1089-4918
    Topics: Physics
    Published by American Physical Society (APS)
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  • 5
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    Evidence of discrete yellowfin tuna (Thunnus albacares) populations demands rethink of management for this globally important resource (2015)
    Springer Nature
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    Publication Date: 2015-11-23
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Published by Springer Nature
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  • 6
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    Effect of heat treatment and surface oxidation on low-cycle fatigue life of Inconel (1970)
    In:  CASI
    Details
    Publication Date: 2019-06-27
    Description: Test program involving specimens with different heat treatment, surface condition, and chemical composition yields low cycle fatigue data on Inconel 718.
    Keywords: MATERIALS
    Type: MFS-18712
    Format: application/pdf
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