Publication Date:
1978-01-27
Description:
Inherited medullary thyroid carcinomas contain one form of glucose-6-phosphate dehydrogenase (G6PD) in black female patients who are mosaic in normal tissues for G6PD types A and B. The same individual may have several tumors each containing either G6PD A or G6PD B. The data suggest that the inherited defect is an initial mutation producing multiple clones of defective cells; each tumor then arises as a final mutation in one clone of these cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Baylin, S B -- Hsu, S H -- Gann, D S -- Smallridge, R C -- Wells, S A Jr -- New York, N.Y. -- Science. 1978 Jan 27;199(4327):429-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/619463" target="_blank"〉PubMed〈/a〉
Keywords:
African Continental Ancestry Group
;
Carcinoma/enzymology/*genetics
;
Clone Cells/enzymology
;
Female
;
Glucosephosphate Dehydrogenase/*genetics/metabolism
;
Humans
;
Isoenzymes/*genetics/metabolism
;
Mosaicism
;
*Mutation
;
Thyroid Neoplasms/enzymology/*genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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