Publication Date:
2013-02-19
Description:
Two glucose-derived thiourea derivatives, 2a and 2b , were prepared by addition of the corresponding amino sugars to a solution of 4-nitrobenzoyl isothiocyanate ( Scheme 1 ). The thioureas were isolated as colorless solids in good yields and were fully characterized by NMR spectroscopy, optical rotation, elemental analysis, and also by single-crystal X-ray diffraction. Attempts to obtain Cu II and Ni II bis(chelate) complexes with these thioureas failed. However, the C(1)-protected thiourea derivative 2a reacted with orthopalladated acetato-bridged dimers to afford the corresponding monomeric Pd II complexes 3 and 4 ( Scheme 2 ). In these compounds, the thiourea coordinates to the metal as monoanionic O,S chelate ligand, which was confirmed by X-ray crystallography.
Print ISSN:
0018-019X
Electronic ISSN:
1522-2675
Topics:
Chemistry and Pharmacology
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