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  • 1
    Online Resource
    Online Resource
    Oxidative Stress and Toxicity in Reproductive Biology and Medicine : A Comprehensive Update on Male Infertility- Volume One (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Toxicology. ; Reproductive health. ; Reproduction. ; Physiology. ; Cytology. ; Developmental biology. ; Environmental chemistry. ; Toxicology. ; Reproductive Medicine. ; Reproductive Physiology. ; Cell Biology. ; Developmental Biology and Stem Cells. ; Environmental Chemistry.
    Description / Table of Contents: Oxidative stress and toxicity in reproductive biology and medicine: Historical perspectives and future horizons in male fertility -- Reactive Oxygen Species in the Reproductive System: Sources and Physiological Roles -- Pathological Roles of Reactive Oxygen Species in Male Reproduction -- Molecular Interactions Associated with Oxidative Stress Mediated Male Infertility: Sperm and Seminal Plasma Proteomics -- Unraveling the Molecular Impact of Sperm DNA Damage on Human Reproduction -- Role of Infection and Leukocytes in Male Infertility -- Bacteriospermia and Male Infertility: Role of Oxidative Stress -- Oxidant-Sensitive Inflammatory Pathways and Male Reproductive Functions -- Oxidative Stress and Idiopathic Male Infertility -- Oxidative Stress and Varicocele-Associated Male Infertility -- Oxidative Stress in Men with Obesity, Metabolic Syndrome and Type 2 Diabetes Mellitus: Mechanisms and Management of Reproductive Dysfunction -- Metabolic dysregulation and sperm motility in male infertility -- Tale of viruses in male infertility -- Pathogenesis of Viral Infections and Male Reproductive Health: An Evidence-Based Study -- Sperm redox system equilibrium: Implications for fertilization and male fertility.
    Abstract: This book discusses the role of oxidative stress in human reproduction with a focus on men’s health. The physiological roles of reactive oxygen species (ROS) in male fertility are the focus in this book. This topic is important because oxidative stress is a result of the imbalance between ROS and antioxidants in the body which may lead to sperm damage (DNA or count), deformity, and eventually, male infertility. Therefore, for a better understanding of the molecular mechanisms related to male genotoxicity and its regulation in infertility, this book provides an up-to-date view on the impact of oxidative stress factors in male reproduction . The main aim of this book is to collect a series of research articles and reviews from a diverse group of scientists to share their research work on the role of ROS or oxidative stress in physiological and pathological states in relation to (in)fertility in the male. This book presents various state-of-the-art chapters of the recent progress in the field of cellular toxicology and clinical manifestations of various issues related to men’s health and fertility. Topics include cell signaling, DNA damage and infertility, the pathophysiology of disease instigation and distribution, immune toxicity and prevention.
    Type of Medium: Online Resource
    Pages: XII, 379 p. 28 illus., 27 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030893408
    Series Statement: Advances in Experimental Medicine and Biology, 1358
    URL: https://doi.org/10.1007/978-3-030-89340-8
    DOI: 10.1007/978-3-030-89340-8
    DDC: 615.90072
    Language: English
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  • 2
    Online Resource
    Online Resource
    Socio-economic and Eco-biological Dimensions in Resource use and Conservation : Strategies for Sustainability (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Environment. ; Biotic communities. ; Biodiversity. ; Conservation biology. ; Ecology . ; Environmental Sciences. ; Ecosystems. ; Biodiversity. ; Conservation Biology.
    Description / Table of Contents: Socio-economic and Eco-biological Dimensions in Resource Use and Conservation: Prologue -- Climate Change impacts and implications: an Indian Perspective -- Local Socio-economic dynamics shaping forest ecosystems in Central Himalayas -- Forests resources of Jharkhand, Eastern India: Socio-economic and bio-ecological perspectives -- Traditional Agroforestry Systems of Northeast India -- Studies on Diversity of Macrofungi In the Tropical Moist Sal Forest of Kamrup District, Assam, India -- Exploring synergistic inter linkages among three ecological issues in the aquatic environment -- Carbon Sequestration Potential of trees in Kuvempu University campus forest area, Western Ghats, Karnataka -- Impact of Weather Shock on Food Insecurity: A Study on India -- Livelihood Strategies and Agricultural Practices In Khonoma Village of Nagaland In India: Observations From Field Study -- Socio-economic and Eco-biological Dimensions in Resource Use and Conservation: Epilogue.
    Abstract: This book presents the outcomes of the 2017 national workshop and international conference organized by CEENR of ISEC, Bengaluru and Assam University Silchar. Addressing the threats to biodiversity and sustainable development resulting from the impacts of human induced pressures on ecosystems and global-warming-driven climate change is a major challenge. It requires increased knowledge and an enhanced information base in order to devise local policies to improve the adaptive capacity of vulnerable socio-ecological systems in developing countries. In this context, the book presents research that has the potential to benefit the environment and empower communities. It appeals to researchers investigating diverse aspects of socio-ecological-biological systems to create strategies for resource use, conservation and management to ensure sustainability.
    Type of Medium: Online Resource
    Pages: XI, 553 p. 95 illus., 73 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030324636
    Series Statement: Environmental Science,
    URL: https://doi.org/10.1007/978-3-030-32463-6
    DOI: 10.1007/978-3-030-32463-6
    DDC: 333.7
    Language: English
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  • 3
    Online Resource
    Online Resource
    Oxidative Stress and Toxicity in Reproductive Biology and Medicine : A Comprehensive Update on Male Infertility Volume II (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Toxicology. ; Reproductive health. ; Reproduction. ; Physiology. ; Medical Toxicology. ; Toxicology. ; Reproductive Medicine. ; Reproductive Physiology.
    Description / Table of Contents: Introduction to Oxidative Stress and Human Reproduction -- Role of Environmental Toxicant Induced Oxidative Stress in Male Infertility -- Effects of Environmental Stressors, Xenobiotics, and Oxidative Stress on Male Reproductive and Sexual Health -- Pesticide Toxicity Associated with Reproductive Infertility -- Impact of Radiation on Male Fertility -- Arsenic-induced Sex Hormone Disruption: An Insight into Male Infertility -- A Perspective on Reproductive Toxicity of Metallic Nanoparticles -- Advanced Techniques of Oxidative Stress Measurement in the Diagnosis of Male Infertility -- Oncofertility: Role of Therapies and Oxidative Stress -- Utility of Oxidation-Reduction Potential in Gametes and Embryos in Assisted Reproductive Technology -- Oxidative Stress and Male Infertility: Role of Herbal Drugs -- Natural Products as Modulators of Oxidative Stress – A Herbal Approach for the Management of Prostate Cancer -- Role of Protein Quality Control in Fertility: Prospects with Phytomedicine -- Pathological Roles of Reactive Oxygen Species on Female Reproduction -- Impact of Oxidative Stress on Embryogenesis -- Etiopathogenesis of Male Factors in Recurrent Pregnancy Loss -- Interplay of Oxidants and Antioxidants in Embryo Culture System -- Use of Antioxidants in Male Infertility -- Reductive Stress and Male Infertility.
    Abstract: Volume Two advances the exploration of the fundamental principles of oxidative stress and toxicity on male (and female) reproduction. It includes the advances in research on male reproductive health, the impact of environmental factors, the protective measures using bioactive compounds and traditional medicines, and how to limit toxic exposure. It includes coverage of: Oxidative stress and male infertility Environmental stressors and sexual health Heavy metals, pesticides, fine particle toxicity and male reproduction Protective measures against oxidative stress in gametes/embryos by using bioactive compounds/phytomedicines in Assisted Reproductive Technology (ART) Role of reactive oxygen species on female reproduction Radiation and mutagenic factors affecting the male reproductive system Both volumes provide a comprehensive look at the most basic concepts and advanced research being conducted by world famous scientists and researchers in male infertility and reproduction.
    Type of Medium: Online Resource
    Pages: XV, 342 p. 350 illus., 344 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031129667
    Series Statement: Advances in Experimental Medicine and Biology, 1391
    URL: https://doi.org/10.1007/978-3-031-12966-7
    DOI: 10.1007/978-3-031-12966-7
    DDC: 615.9
    Language: English
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  • 4
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    Effect of Lipopolysaccharide and Muramyl Dipeptide on Apoptosis of Bovine Mammary Gland Lymphocytes (2020)
    Molecular Diversity Preservation International
    Details
    Publication Date: 2020-06-05
    Description: The aim of this study was to evaluate whether apoptosis of lymphocytes is modulated by stimulation by lipopolysaccharide (LPS) of Escherichia coli or muramyl dipeptide (MDP). Cell populations were obtained by lavaging of the mammary glands 24, 48, 72, and 168 h following intramammary induced inflammation. The portion of apoptotic lymphocytes peaked at 48 h after treatment with LPS or MDP. The analysis of CD44 expression of the same cell populations showed a higher percentage of CD44-positive lymphocytes 24- and 48-h following induction of inflammation by LPS or MDP. The results demonstrate that during both experimental infection of bovine mammary glands with LPS or MDP, apoptosis of lymphocytes was induced in the initial phase of the inflammatory response and CD44 was also overexpressed at the beginning of inflammation. These data suggest a connection of lymphocyte apoptosis with the expression of CD44 receptors.
    Electronic ISSN: 2076-2615
    Topics: Biology , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Published by Molecular Diversity Preservation International
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  • 5
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    Viral Pandemics of the Last Four Decades: Pathophysiology, Health Impacts and Perspectives (2020)
    Molecular Diversity Preservation International
    Details
    Publication Date: 2020-12-15
    Description: The last four decades has witnessed some of the deadliest viral pandemics with far-reaching consequences. These include the Human Immunodeficiency Virus (HIV) (1981), Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) (2002), Influenza A virus subtype H1N1 (A/H1N1) (2009), Middle East Respiratory Syndrome Coronavirus (MERS-CoV) (2012), Ebola virus (2013) and the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) (2019-present). Age- and gender-based characterizations suggest that SARS-CoV-2 resembles SARS-CoV and MERS-CoV with regard to higher fatality rates in males, and in the older population with comorbidities. The invasion-mechanism of SARS-CoV-2 and SARS-CoV, involves binding of its spike protein with angiotensin-converting enzyme 2 (ACE2) receptors; MERS-CoV utilizes dipeptidyl peptidase 4 (DPP4), whereas H1N1 influenza is equipped with hemagglutinin protein. The viral infections-mediated immunomodulation, and progressive inflammatory state may affect the functions of several other organs. Although no effective commercial vaccine is available for any of the viruses, those against SARS-CoV-2 are being developed at an unprecedented speed. Until now, only Pfizer/BioNTech’s vaccine has received temporary authorization from the UK Medicines and Healthcare products Regulatory Agency. Given the frequent emergence of viral pandemics in the 21st century, proper understanding of their characteristics and modes of action are essential to address the immediate and long-term health consequences.
    Print ISSN: 1661-7827
    Electronic ISSN: 1660-4601
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Published by Molecular Diversity Preservation International
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  • 6
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    Oxidative Stress in Cancer Cell Metabolism (2021)
    Molecular Diversity Preservation International
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    Publication Date: 2021-04-22
    Description: Reactive oxygen species (ROS) are important in regulating normal cellular processes whereas deregulated ROS leads to the development of a diseased state in humans including cancers. Several studies have been found to be marked with increased ROS production which activates pro-tumorigenic signaling, enhances cell survival and proliferation and drives DNA damage and genetic instability. However, higher ROS levels have been found to promote anti-tumorigenic signaling by initiating oxidative stress-induced tumor cell death. Tumor cells develop a mechanism where they adjust to the high ROS by expressing elevated levels of antioxidant proteins to detoxify them while maintaining pro-tumorigenic signaling and resistance to apoptosis. Therefore, ROS manipulation can be a potential target for cancer therapies as cancer cells present an altered redox balance in comparison to their normal counterparts. In this review, we aim to provide an overview of the generation and sources of ROS within tumor cells, ROS-associated signaling pathways, their regulation by antioxidant defense systems, as well as the effect of elevated ROS production in tumor progression. It will provide an insight into how pro- and anti-tumorigenic ROS signaling pathways could be manipulated during the treatment of cancer.
    Electronic ISSN: 2076-3921
    Topics: Chemistry and Pharmacology
    Published by Molecular Diversity Preservation International
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  • 7
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    A Comparative Cross-Platform Meta-Analysis to Identify Potential Biomarker Genes Common to Endometriosis and Recurrent Pregnancy Loss (2021)
    Molecular Diversity Preservation International
    Details
    Publication Date: 2021-04-08
    Description: Endometriosis is characterized by unwanted growth of endometrial tissue in different locations of the female reproductive tract. It may lead to recurrent pregnancy loss, which is one of the worst curses for the reproductive age group of human populations around the world. Thus, there is an urgent need for unveiling any common source of origin of both these diseases and connections, if any. Herein, we aimed to identify common potential biomarker genes of these two diseases via in silico approach using meta-analysis of microarray data. Datasets were selected for the study based on certain exclusion criteria. Those datasets were subjected to comparative meta-analyses for the identification of differentially expressed genes (DEGs), that are common to both diagnoses. The DEGs were then subjected to protein-protein networking and subsequent functional enrichment analyses for unveiling their role/function in connecting two diseases. From the analyses, 120 DEGs are reported to be significant out of which four genes have been found to be prominent. These include the CTNNB1, HNRNPAB, SNRPF and TWIST2 genes. The significantly enriched pathways based on the above-mentioned genes are mainly centered on signaling and developmental events. These findings could significantly elucidate the underlying molecular events in endometriosis-based recurrent miscarriages.
    Electronic ISSN: 2076-3417
    Topics: Natural Sciences in General
    Published by Molecular Diversity Preservation International
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  • 8
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    The Multiple Actions of Amygdalin on Cellular Processes with an Emphasis on Female Reproduction (2021)
    Molecular Diversity Preservation International
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    Publication Date: 2021-08-30
    Description: The present review summarizes the current knowledge on the provenance and properties, metabolism and toxicity, mechanism of action, physiological, and therapeutic roles of amygdalin—a molecule present in the seeds of apricot and other plants—with an emphasis on the action of amygdalin on reproductive processes, particularly in the female. Amygdalin influences physiological processes including female reproduction at various regulatory levels via extra- and intracellular signaling pathways regulating secretory activity, cell viability, steroidogenesis, proliferation, and apoptosis. On the other hand, while being metabolized in the body, amygdalin releases significant amounts of cyanide, which may lead to acute health hazard in those individuals who may be at risk. Despite some contradictions in the available data about benefits and toxic effects of amygdalin, its potential applicability at low doses may present a promising tool for regulation of various reproductive and other physiological processes including disease management primarily in cancer phytotherapy, animal production, medicine, and biotechnology. However, further research involving carefully designed dose–response studies is required to overcome the possible side effects of amygdalin and assure its safety as a therapeutic agent.
    Electronic ISSN: 1424-8247
    Topics: Chemistry and Pharmacology
    Published by Molecular Diversity Preservation International
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  • 9
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    In vitro effect of ferrous sulphate on bovine spermatozoa motility parameters, viability and Annexin V-labeled membrane changes (2021)
    Public Library of Science
    Details
    Publication Date: 2021-09-23
    Description: The aim of this study was to assess the dose- and time-dependent in vitro effects of ferrous sulphate (FeSO4.7H2O) on the motility parameters, viability, structural and functional activity of bovine spermatozoa. Spermatozoa motility parameters were determined after exposure to concentrations (3.90, 7.80, 15.60, 31.20, 62.50, 125, 250, 500 and 1000 μM) of FeSO4.7H2O using the SpermVisionTM CASA (Computer Assisted Semen Analyzer) system in different time periods. Cell viability was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide (MTT) assay, and the Annexin V-Fluos was applied to detect the membrane integrity of spermatozoa. The initial spermatozoa motility showed increased average values at all experimental concentrations compared to the control group (culture medium without FeSO4.7H2O). After 2 h, FeSO4.7H2O stimulated the overall percentage of spermatozoa motility at the concentrations of ≤ 125 μM. However, experimental administration of 250 μM of FeSO4.7H2O significantly (P 〈 0.001) decreased the spermatozoa motility but had no negative effect on the cell viability (P 〈 0.05) (Time 2 h). The lowest viability was noted after the addition of ≥ 500 μM of FeSO4.7H2O (P 〈 0.001). The concentrations of ≤ 62.50 μM of FeSO4.7H2O markedly stimulated (P 〈 0.001) spermatozoa activity after 24 h of exposure, while at high concentrations of ≥ 500 μM of FeSO4.7H2O the overall percentage of spermatozoa motility was significantly inhibited (P 〈 0.001) and it elicited cytotoxic action. Fluorescence analysis confirmed that spermatozoa incubated with higher concentrations (≥ 500 μM) of FeSO4.7H2O displayed apoptotic changes, as detected in head membrane (acrosomal part) and mitochondrial portion of spermatozoa. Moreover, the highest concentration and the longest time of exposure (1000 μM of FeSO4.7H2O; Time 6 h) induced even necrotic alterations to spermatozoa. These results suggest that high concentrations of FeSO4.7H2O are able to induce toxic effects on the structure and function of spermatozoa, while low concentrations may have the positive effect on the fertilization potential of spermatozoa.
    Electronic ISSN: 1932-6203
    Topics: Medicine , Natural Sciences in General
    Published by Public Library of Science
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  • 10
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    Oxidative Stress, Testicular Inflammatory Pathways, and Male Reproduction (2021)
    Molecular Diversity Preservation International
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    Publication Date: 2021-09-17
    Description: Inflammation is among the core causatives of male infertility. Despite male infertility being a serious global issue, “bits and pieces” of its complex etiopathology still remain missing. During inflammation, levels of proinflammatory mediators in the male reproductive tract are greater than usual. According to epidemiological research, in numerous cases of male infertility, patients suffer from acute or chronic inflammation of the genitourinary tract which typically occurs without symptoms. Inflammatory responses in the male genital system are inextricably linked to oxidative stress (OS). OS is detrimental to male fertility parameters as it causes oxidative damage to reproductive cells and intracellular components. Multifarious male infertility causative factors pave the way for impairing male reproductive functions via the common mechanisms of OS and inflammation, both of which are interlinked pathophysiological processes, and the occurrence of any one of them induces the other. Both processes may be simultaneously found in the pathogenesis of male infertility. Thus, the present article aims to explain the role of inflammation and OS in male infertility in detail, as well as to show the mechanistic pathways that link causative factors of male reproductive tract inflammation, OS induction, and oxidant-sensitive cellular cascades leading to male infertility.
    Print ISSN: 1661-6596
    Electronic ISSN: 1422-0067
    Topics: Chemistry and Pharmacology
    Published by Molecular Diversity Preservation International
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