ISSN:
0006-3525
Keywords:
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The preparation of the co-oligopeptides of the series H-Gly-Trp-(Gly)n-Trp-Gly-OH (n = 0, 1, and 2) and of a number of other unprotected co-oligopeptides of glycine and tryptophan is reported. The syntheses have been carried out by conventional methods, using, in general, N-hydroxysuccinimide esters for the coupling steps. All the oligopeptides were obtained after purfication as colorless and crystalline products, and gave only one spot on thin-layer chromatography. Specfic problems connected with the synthesis and purficiation of optically pure tryptophan-containing peptides are discussed.
Additional Material:
3 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/bip.1975.360141108
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