Publication Date:
1986-07-18
Description:
A human complementary DNA whose protein product is considered to be the major component of scrapie-associated fibrils in Creutzfeldt-Jakob disease, kuru, and Gerstmann-Straussler syndrome has been identified and characterized. The extensive homology of this gene sequence to the hamster PrP 27- to 30-kilodalton prion protein complementary DNA clone, and its existence as a single copy in the human genome, leads to the conclusion that this is the human prion gene. This human prion gene has been mapped to human chromosome 20, negating a direct link between the prion protein and Down's syndrome or the amyloid of Alzheimer's disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Liao, Y C -- Lebo, R V -- Clawson, G A -- Smuckler, E A -- CA 21141/CA/NCI NIH HHS/ -- CA 40145/CA/NCI NIH HHS/ -- KO4 CA 01003/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1986 Jul 18;233(4761):364-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3014653" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Animals
;
Base Sequence
;
Chromosome Mapping
;
Chromosomes, Human, 19-20
;
Chromosomes, Human, 21-22 and Y
;
*Cloning, Molecular
;
Creutzfeldt-Jakob Syndrome/genetics/microbiology
;
Cricetinae
;
DNA/*analysis
;
DNA Restriction Enzymes/metabolism
;
Humans
;
Prions/*genetics
;
Viral Proteins/analysis
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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