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  • 1
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    A correlation between platelet monoamine oxidase activity and plasma prolactin concentrations in man (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-26
    Description: Increases in plasma prolactin concentrations produced by alpha-methyl-p-tyrosine, a catecholamine synthesis inhibitor, varied inversely with baseline platelet monoamine oxidase activity in 12 patients with chronic schizophrenia. In normal volunteers with low monoamine oxidase activity and in unmedicated patients with chronic schizophrenia, plasma prolactin concentrations varied directly with platelet monoamine oxidase activity. No such relationship was found in normal subjects with high platelet monoamine oxidase activity. These data suggest that platelet monoamine oxidase activity reflects monoaminergic activity in the tubero-infundibular system, which in turn affects plasma prolactin concentrations. This relationship may be important in patients with low platelet monoamine oxidase activity, such as some chronic schizophrenics.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kleinman, J E -- Potkin, S -- Rogol, A -- Buchsbaum, M S -- Murphy, D L -- Gillin, J C -- Nasrallah, H A -- Wyatt, R J -- New York, N.Y. -- Science. 1979 Oct 26;206(4417):479-81.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/504993" target="_blank"〉PubMed〈/a〉
    Keywords: Blood Platelets/*enzymology ; Humans ; Hypothalamus/physiology ; Methyltyrosines/pharmacology ; Monoamine Oxidase/*blood ; Prolactin/*blood ; Schizophrenia/blood
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Kindling induces long-lasting alterations in response of hippocampal neurons to elevated potassium levels in vitro (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-06-13
    Description: The cellular basis of kindling was studied electrophysiologically with slices of guinea pig hippocampus. Normally, epileptiform activity can be induced in the slices only by combined exposure to elevated potassium levels and a chemical convulsant such as penicillin. In hippocampal slices from pentylenetetrazole-kindled animals, however, elevated potassium alone can induce seizures. These data suggest that kindling elicits long-term changes in neuronal excitability that may involve ionic mechanisms.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Oliver, A P -- Hoffer, B J -- Wyatt, R J -- New York, N.Y. -- Science. 1980 Jun 13;208(4449):1264-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7375936" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dose-Response Relationship, Drug ; Epilepsy/chemically induced/*physiopathology ; Guinea Pigs ; Hippocampus/drug effects/*physiology ; In Vitro Techniques ; Male ; Neurons/drug effects/physiology ; Pentylenetetrazole/administration & dosage/pharmacology ; Potassium/*pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Calcitonin: aversive effects in rats? (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-02-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Freed, W J -- Bing, L A -- Wyatt, R J -- New York, N.Y. -- Science. 1981 Feb 13;211(4483):734.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17776657" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Calcitonin: inhibitory effect on eating in rats (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-16
    Description: Subcutaneous and intracerebral injections of calcitonin inhibited feeding in rats. The anorectic activity of calcitonin was destroyed by exposing the hormone to heat, trypsin, or hydrogen peroxide. Calcitonin did not produce a conditioned taste aversion to saccharin, and maximum inhibition of feeding occurred 4.5 to 8.3 hours after subcutaneous administration. It is concluded that calcitonin inhibits feeding by acting directly on the central nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Freed, W J -- Perlow, M J -- Wyatt, R J -- New York, N.Y. -- Science. 1979 Nov 16;206(4420):850-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493987" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/drug effects ; Calcitonin/administration & dosage/*pharmacology ; Depression, Chemical ; Diuresis/drug effects ; Dose-Response Relationship, Drug ; Feeding Behavior/*drug effects ; Injections, Intraventricular ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Normalization of spiroperidol binding in the denervated rat striatum by homologous grafts of substantia nigra (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-11-25
    Description: Transplantation of embryonic substantia nigra into the adult rat brain decreases the motor asymmetry that is produced by dopamine receptor supersensitivity after a unilateral lesion of the substantia nigra. The authors report that this effect of transplantation is specific to grafts of substantia nigra. They also report that, in conjunction with the decrease in motor asymmetry, these grafts cause postsynaptic dopaminergic binding sites to return to normal density as measured by tritiated spiroperidol autoradiography. Thus, in animals with brain lesions, grafts of substantia nigra produce a long-term alteration in the functional status of host brain cell receptors that is associated with a reduction in the behavioral deficit.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Freed, W J -- Ko, G N -- Niehoff, D L -- Kuhar, M J -- Hoffer, B J -- Olson, L -- Cannon-Spoor, H E -- Morihisa, J M -- Wyatt, R J -- MH-00289/MH/NIMH NIH HHS/ -- MH-25951/MH/NIMH NIH HHS/ -- NS-09199/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1983 Nov 25;222(4626):937-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6635666" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Apomorphine/pharmacology ; Autoradiography ; Denervation ; Dextroamphetamine/pharmacology ; Motor Activity/drug effects ; Rats ; Rats, Inbred Strains ; Receptors, Dopamine/*metabolism ; Spiperone/metabolism ; Substantia Nigra/*transplantation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Brain grafts reduce motor abnormalities produced by destruction of nigrostriatal dopamine system (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-05-11
    Description: In order to determine if brain tissue grafts can provide functional input to recipient central nervous system tissue, fetal rat dopamine-containg neurons were implanted adjacent to the caudate nucleus of adult recipients whose endogenous dopaminergic input had been destroyed. The grafts showed good survival and axonal outgrowth. Motor abnormalities, which had been induced by the destruction of the endogenous dopaminergic input to the caudate, were significantly reduced after grafting of the fetal brain tissue. These data suggest that such implants may be potentially useful in reversing deficits after circumscribed destruction of brain tissue.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Perlow, M J -- Freed, W J -- Hoffer, B J -- Seiger, A -- Olson, L -- Wyatt, R J -- New York, N.Y. -- Science. 1979 May 11;204(4393):643-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/571147" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Corpus Striatum/physiology ; Disease Models, Animal ; Graft Survival ; Humans ; Hydroxydopamines/toxicity ; Male ; Movement Disorders/physiopathology ; Parkinson Disease/therapy ; Rats ; Stereotyped Behavior/physiology ; Substantia Nigra/embryology/physiology/*transplantation ; Transplantation, Homologous
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Phenylethylamine in paranoid chronic schizophrenia (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-26
    Description: Phenylethylamine (PEA) is an endogenous amine that is structurally and pharmacologically related to amphetamine. Urinary PEA excretion is significantly higher in paranoid chronic schizophrenics than in nonparanoid chronic schizophrenics and normal controls. Diet, hospitalization, and medication do not account for differences in PEA concentrations. These findings offer some indication that PEA may be an endogenous amphetamine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Potkin, S G -- Karoum, F -- Chuang, L W -- Cannon-Spoor, H E -- Phillips, I -- Wyatt, R J -- New York, N.Y. -- Science. 1979 Oct 26;206(4417):470-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/504988" target="_blank"〉PubMed〈/a〉
    Keywords: Chronic Disease ; Diet ; Hospitalization ; Humans ; Phenethylamines/*urine ; Schizophrenia/urine ; Schizophrenia, Paranoid/*urine
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Scienceless to homeless (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-12-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wyatt, R J -- DeRenzo, E G -- New York, N.Y. -- Science. 1986 Dec 12;234(4782):1309.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3787247" target="_blank"〉PubMed〈/a〉
    Keywords: Deinstitutionalization ; *Homeless Persons ; Humans ; *Public Policy ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Response: homelessness (1987)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1987-02-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wyatt, R J -- Derenzo, E -- New York, N.Y. -- Science. 1987 Feb 27;235(4792):956a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17782226" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Promoting functional plasticity in the damaged nervous system (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-03-29
    Description: Damage to the central and peripheral nervous system often produces lasting functional deficits. A major focus of neuroscience research has been to enhance functional restitution of the damaged nervous system and thereby produce recovery of behavioral or physiological processes. Promising procedures include surgical, physical, and chemical manipulations to reduce scar formation and minimize the disruption of support elements, administration of growth-stimulating substances, tissue grafts to bridge gaps in fiber pathways, and embryonic brain tissue grafts to provide new cells with the potential to generate fiber systems. Two elements are required for functional nervous system repair: (i) neurons with the capacity to extend processes must be present, and (ii) the regenerating neurites must find a continuous, unbroken pathway to appropriate targets through a supportive milieu.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Freed, W J -- de Medinaceli, L -- Wyatt, R J -- New York, N.Y. -- Science. 1985 Mar 29;227(4694):1544-52.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3975624" target="_blank"〉PubMed〈/a〉
    Keywords: Age Factors ; Amphibians ; Animals ; Axons/physiology ; Cell Membrane/physiology ; Central Nervous System/embryology ; Gangliosides/physiology ; Glycoproteins/physiology ; Lampreys ; Nerve Growth Factors/physiology ; Nerve Regeneration ; *Neuronal Plasticity ; Neurosecretory Systems/physiology ; Peripheral Nerve Injuries ; Peripheral Nerves/physiology ; Rats ; Retina/physiology ; Spinal Cord Injuries/physiopathology ; *Trauma, Nervous System
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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