Publication Date:
1994-11-18
Description:
An equilibrium phase belonging to the family of bilayer liposomes in ternary mixtures of dimyristoylphosphatidylcholine (DMPC), water, and geraniol (a biological alcohol derived from oil-soluble vitamins that acts as a cosurfactant) has been identified. Electron and optical microscopy reveal the phase, labeled Ltv, to be composed of highly entangled tubular vesicles. In situ x-ray diffraction confirms that the tubule walls are multilamellar with the lipids in the chain-melted state. Macroscopic observations show that the Ltv phase coexists with the well-known L4 phase of spherical vesicles and a bulk L alpha phase. However, the defining characteristic of the Ltv phase is the Weissenberg rod climbing effect under shear, which results from its polymer-like entangled microstructure.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chiruvolu, S -- Warriner, H E -- Naranjo, E -- Idziak, S H -- Radler, J O -- Plano, R J -- Zasadzinski, J A -- Safinya, C R -- GM47334/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1994 Nov 18;266(5188):1222-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Materials Research Laboratory, University of California, Santa Barbara 93106.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7973704" target="_blank"〉PubMed〈/a〉
Keywords:
Dimyristoylphosphatidylcholine/*chemistry
;
Lipid Bilayers/*chemistry
;
Liposomes/*chemistry
;
Microscopy, Electron
;
Scattering, Radiation
;
Temperature
;
Terpenes/*chemistry
;
X-Ray Diffraction
;
X-Rays
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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