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  • 1
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    Detrital zircon U-Pb provenance of the Colorado River: A 5 m.y. record of incision into cover strata overlying the Colorado Plateau and adjacent regions (2015)
    Geological Society of America (GSA)
    In: Geosphere
    Details
    Publication Date: 2015-12-02
    Description: New detrital zircon U-Pb age distributions from 49 late Cenozoic sandstones and Holocene sands (49 samples, n = 3922) record the arrival of extra-regional early Pliocene Colorado River sediment at Grand Wash (western USA) and downstream locations ca. 5.3 Ma and the subsequent evolution of the river’s provenance signature. We define reference age distributions for the early Pliocene Colorado River (n = 559) and Holocene Colorado River (n = 601). The early Pliocene river is distinguished from the Holocene river by (1) a higher proportion of Yavapai-Mazatzal zircon derived from Rocky Mountain basement uplifts relative to Grenville zircon from Mesozoic supra crustal rocks, and (2) distinctive (~6%) late Eocene–Oligocene (40–23 Ma) zircon reworked from Cenozoic basins and volcanic fields in the southern Rocky Mountains and/or the eastern Green River catchment. Geologic relationships and interpretation of 135 published detrital zircon age distributions throughout the Colorado River catchment provide the interpretative basis for modeling evolution of the provenance signature. Mixture modeling based upon a modified formulation of the Kolmogorov-Smirnov statistic indicate a subtle yet robust change in Colorado River provenance signature over the past 5 m.y. During this interval the contribution from Cenozoic strata decreased from ~75% to 50% while pre-Cretaceous strata increased from ~25% to 50%. We interpret this change to reflect progressive erosional incision into plateau cover strata. Our finding is consistent with geologic and thermochronologic studies that indicate that maximum post–10 Ma erosion of the Colorado River catchment was concentrated across the eastern Utah–western Colorado region.
    Electronic ISSN: 1553-040X
    Topics: Geosciences
    Published by Geological Society of America (GSA)
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  • 2
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    Putting brain training to the test (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-04-22
    Description: 'Brain training', or the goal of improved cognitive function through the regular use of computerized tests, is a multimillion-pound industry, yet in our view scientific evidence to support its efficacy is lacking. Modest effects have been reported in some studies of older individuals and preschool children, and video-game players outperform non-players on some tests of visual attention. However, the widely held belief that commercially available computerized brain-training programs improve general cognitive function in the wider population in our opinion lacks empirical support. The central question is not whether performance on cognitive tests can be improved by training, but rather, whether those benefits transfer to other untrained tasks or lead to any general improvement in the level of cognitive functioning. Here we report the results of a six-week online study in which 11,430 participants trained several times each week on cognitive tasks designed to improve reasoning, memory, planning, visuospatial skills and attention. Although improvements were observed in every one of the cognitive tasks that were trained, no evidence was found for transfer effects to untrained tasks, even when those tasks were cognitively closely related.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2884087/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2884087/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Owen, Adrian M -- Hampshire, Adam -- Grahn, Jessica A -- Stenton, Robert -- Dajani, Said -- Burns, Alistair S -- Howard, Robert J -- Ballard, Clive G -- MC_U105559837/Medical Research Council/United Kingdom -- MC_U105559847/Medical Research Council/United Kingdom -- U.1055.01.002.00001.01/Medical Research Council/United Kingdom -- U.1055.01.002.00001.01(80449)/Medical Research Council/United Kingdom -- U.1055.01.003.00001.01/Medical Research Council/United Kingdom -- England -- Nature. 2010 Jun 10;465(7299):775-8. doi: 10.1038/nature09042.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 7EF, UK. adrian.owen@mrc-cbu.cam.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20407435" target="_blank"〉PubMed〈/a〉
    Keywords: Attention/physiology ; Brain/*physiology ; Cognition/*physiology ; Computers ; Exercise/*physiology ; Humans ; Memory/physiology ; Task Performance and Analysis ; Thinking/physiology ; Time Factors
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 3
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    Research toward malaria vaccines (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-12-12
    Description: Malaria exacts a toll of disease to people in the Tropics that seems incomprehensible to those only familiar with medicine and human health in the developed world. The methods of molecular biology, immunology, and cell biology are now being used to develop an antimalarial vaccine. The Plasmodium parasites that cause malaria have many stages in their life cycle. Each stage is antigenically distinct and potentially could be interrupted by different vaccines. However, achieving complete protection by vaccination may require a better understanding of the complexities of B- and T-cell priming in natural infections and the development of an appropriate adjuvant for use in humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miller, L H -- Howard, R J -- Carter, R -- Good, M F -- Nussenzweig, V -- Nussenzweig, R S -- P01-AI17429/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1986 Dec 12;234(4782):1349-56.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2431481" target="_blank"〉PubMed〈/a〉
    Keywords: Antigens, Protozoan/analysis ; Arthropod Vectors ; Epitopes/analysis ; Erythrocytes/parasitology ; Humans ; *Immunotherapy ; Malaria/immunology/*prevention & control/transmission ; Molecular Weight ; Mosquito Control ; Plasmodium/immunology ; Receptors, Antigen, T-Cell/immunology ; T-Lymphocytes, Helper-Inducer/immunology ; *Vaccines
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    A mechanism for surface attachment in spores of a plant pathogenic fungus (1988)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1988-01-15
    Description: Rice blast disease is caused by a fungus that attacks all above-ground parts of the rice plant. In a study of the means by which the fungus attaches to the hydrophobic rice leaf surface, it was found that spores(conidia) of the rice blast fungus Magnaporthe grisea have a mechanism for immediate and persistent attachment to various surfaces, including Teflon. This attachment occurs at the spore apex and is blocked by the addition of the lectin concanavalin A. Microscopy of hydrated conidia shows that a spore tip mucilage that binds concanavalin A is expelled specifically from the conidial apex before germ tube emergence. Ultrastructural analysis of dry conidia shows a large periplasmic deposit, presumably spore tip mucilage, at the apex. The results indicate a novel mechanism for the attachment of phytopathogenic fungal spores to a plant surface.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hamer, J E -- Howard, R J -- Chumley, F G -- Valent, B -- New York, N.Y. -- Science. 1988 Jan 15;239(4837):288-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17769992" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Antigens induced on erythrocytes by P. falciparum: expression of diverse and conserved determinants (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-01-10
    Description: Red blood cells that are infected with the malaria parasite Plasmodium falciparum express new antigens on their surface. In a study of these antigens in the erythrocytes of naturally infected children in the Gambia, an antibody-mediated agglutination assay revealed an extreme degree of antigenic diversity. Serum samples from each of ten children in the convalescent stage of malaria infection reacted with infected cells from the same child but generally not with infected cells from the other children. The Gambian children's erythrocytes also expressed shared determinants: sera from Gambian adults often reacted with the surface of infected cells from all of the children and were shown by adsorption and elution experiments to contain antibodies that recognized several isolates. Conserved determinants exposed on infected erythrocytes may be important for development of antimalarial immunity either naturally or through vaccination.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marsh, K -- Howard, R J -- New York, N.Y. -- Science. 1986 Jan 10;231(4734):150-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2417315" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Agglutination Tests ; Antigens, Protozoan/*immunology ; Child ; *Epitopes ; Erythrocytes/immunology/*parasitology ; Gambia ; Humans ; Malaria/*immunology ; Plasmodium falciparum
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
    Electronic Resource
    Electronic Resource
    Radioiodination of Parasite Antigens with 1,3,4,6,-Tetrachloro-3α,6α-diphenylglycoluril (IODOGEN): Studies with Zygotes of Plasmodium gallinaceum (1982)
    Oxford, UK : Blackwell Publishing Ltd
    The @journal of eukaryotic microbiology 29 (1982), S. 0 
    Details
    ISSN: 1550-7408
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: The iodinating reagent 1,3,4,6,-tetrachloro-3α,6α-diphenylglycoluril (IODOGEN3) was used to label antigens on zygotes of Plasmodium gallinaceum with parallel studies using lactoperoxidase-catalyzed radioiodination for comparison. Proteins labeled by the IODOGEN method are most probably on the surface of the zygote, as the pattern of labeled proteins analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis was very similar to the pattern of lactoperoxidase-labeled proteins. Furthermore, the labeled proteins represented only a subset of the total Coomassie Blue-stained proteins. The radioiodinated zygote proteins were immuno-reactive after IODOGEN or lactoperoxidase labeling. The IODOGEN method is technically much more simple than the lactoperoxidase method and does not require the addition of extraneous proteins or H2O2. The advantages of IODOGEN labeling, together with the essential equivalence of results obtained by these two, methods, make the IODOGEN method attractive for labeling parasite antigens in general.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1550-7408.1982.tb02891.x
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  • 7
    Electronic Resource
    Electronic Resource
    Effect of Virus Infections on the Function of the Immune System (1970)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Microbiology 24 (1970), S. 525-538 
    Details
    ISSN: 0066-4227
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.mi.24.100170.002521
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  • 8
    Electronic Resource
    Electronic Resource
    Characterization of Ascochyta isolates and susceptibility of pea cultivars to the ascochyta disease complex in Alberta (2000)
    Oxford, UK : Blackwell Science Ltd
    Plant pathology 49 (2000), S. 0 
    Details
    ISSN: 1365-3059
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: The relative virulence of 109 Ascochyta isolates collected from pea fields in Alberta from 1996 to 1998 were evaluated on 10-day-old seedlings by the excised leaf-assay technique. Twenty-eight isolates were avirulent, while the others produced lesions of various sizes on pea leaves. DNA samples from 86 isolates were amplified by the RAPD technique using PCR with single primers. One dominant genotype of Ascochyta pisi was identified throughout Alberta, but variations in virulence were not clearly differentiated by the RAPD technique. Five Ascochyta isolates, four virulent and one avirulent, were used to assess the susceptibility of 20 field pea cultivars available in Alberta, including 13 yellow types and seven green types. Based on symptom development, the yellow-type cultivars Swing, Eiffel and Delta, and the green-type cultivar Orb, were the most susceptible. Of yellow-type cultivars, Voyageur, Carneval and Montana were most resistant to Ascochyta infection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-3059.2000.00489.x
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  • 9
    Electronic Resource
    Electronic Resource
    A rapid millimetre wave outburst in the nucleus of NGC1275 (1983)
    [s.l.] : Nature Publishing Group
    Nature 306 (1983), S. 41-42 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The Seyfert-like galaxy NGC1275 (3C84 or 0316 + 41) was the first radio source found to have an inverted radio spectrum2 and was also one of the first sources known to be variable at centimetre wavelengths3. Since 1960 its centimetre-wavelength emission has risen steadily. Its millimetre-wavelength ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/306041a0
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  • 10
    Electronic Resource
    Electronic Resource
    A flare in the millimetre to IR spectrum of 3C273 (1983)
    [s.l.] : Nature Publishing Group
    Nature 305 (1983), S. 194-196 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Between 2 and 6 February 1983 we measured the spectrum of 3C273 in 10 wavebands between 1.2 ?? and 1.1 mm (J, H, K, L, M, 10, 20, 400, 800, 1,100 ??) with the United Kingdom Infrared Telescope (UKIRT) and found that its flux density at all wavelengths had increased. On 26 February, 1.3- and 2.0-mm ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/305194a0
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