ISSN:
0009-2940
Keywords:
Rhenium complexes
;
Technetium complexes
;
Radiopharmaceuticals
;
Dithioether ligands
;
Dithiaalcohols
;
Chemistry
;
Inorganic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Neutral oxorhenium(V) complexes of the general formula ReO(L)Cl2 are obtained by reaction of [ReO4]- or [ReOCl4]- with functionalized dithiaalcohols (L) containing the donor atom sequences S, S, O- and S, O-, S. Ligand exchange reaction of [ReOCl4]- with HO(CH2)2S(CH2)2S(CH2)2O (R = H, Et ) leads to the formation of ReOCl2[O(CH2)2S(CH2)2-S(CH2)2OEt] (1b). Reduction of [ReO4]- with a 1:1 mixture of concentrated HCl and glacial acetic acid in the presence of nBuSCH2- CH(OH)CH2S-nBu yield ReOCl2[OCH(CH2S-nBu)2) (4). X-ray structure analysis of 1a, 1b and 4 shows distorted octahedral coordination with the chlorine and sulfur atoms in the equatorial plane. The oxygen of the hydroxyl group coordinates in a trans position with respect to the Re=O core. 1a reacts with an excess of acetyl chloride in an unexpected way, resulting in cleavage of the trans Re-O bond and acylation of both of the hydroxyl groups to form the μ-oxo bridged complex [ReOCl2{CH3COO{CH2)2S(CH2)2PPC-CH3}}2O (3).
Additional Material:
4 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/cber.19971300309
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