ISSN:
1420-9071
Keywords:
Rat
;
cerebrospinal fluid, human
;
analgesia
;
naloxone
;
pain indifference, congenital
;
opiates, endogenous
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary CSF from a patient with congential indifference to pain was found to produce analgesia in the rat following intracerebroventricular injections. The analgesic effect was attenuated by pretreatment with naloxone suggesting the involvement of hyperactive endogenous opiate mechanisms in this patient.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01951891
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