ISSN:
1420-9071
Keywords:
Pineal
;
thyroxine
;
deiodinase
;
phenylephrine
;
isoproterenol
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract In the present study we show, for the first time, that phenylephrine (PHE), an α-adrenergic receptor agonist, potentiates the effect of isoproterenol (ISO), a β-adrenergic agonist, in activating pineal type II5′-deiodinase (5′-D) activity. The potentiating effect of PHE was observed only at doses of ISO which induce submaximal activation of the enzyme. However, at doses which lead to maximal activation of the enzyme, PHE was ineffective. The results suggest that not only β-, but also α-adrenergic receptors, are involved in the sympathetic noradrenergic regulation of pineal 5′-D activity in the adult rat.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01923413
Permalink