ISSN:
0899-0042
Keywords:
aminophosphonic acids
;
asymmetric synthesis
;
chiral HPLC
;
ligand-exchange chromatography
;
enantiomeric analysis
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
An aqueous solution of the (+)-monoethyl ester of N-(l′-hydroxymethyl-)propyl-α-aminobenzylphosphonic acid has been proposed as a suitable chiral eluent for enantiomeric analysis of amino acids by ligand-exchange chromatography. Asymmetric synthesis of the chiral selector using (-)-(R)-2-aminobutan-1-ol as a starting reactant is described. The dependence of the parameters of separation of valine enantiomers on concentration of the complexing ion, pH, and temperature has been investigated. It is shown that the order in which enantiomers are eluted from a column depends on the concentration of the complexing ion and pH. © 1996 Wiley-Liss, Inc.
Additional Material:
4 Tab.
Type of Medium:
Electronic Resource
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