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  • 1
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    A Sleeping Beauty transposon-mediated screen identifies murine susceptibility genes for adenomatous polyposis coli (Apc)-dependent intestinal tumorigenesis [Medical Sciences] (2011)
    National Academy of Sciences
    Details
    Publication Date: 2011-04-06
    Description: It is proposed that a progressive series of mutations and epigenetic events leads to human colorectal cancer (CRC) and metastasis. Furthermore, data from resequencing of the coding regions of human CRC suggests that a relatively large number of mutations occur in individual human CRC, most at low frequency. The functional role of these low-frequency mutations in CRC, and specifically how they may cooperate with high-frequency mutations, is not well understood. One of the most common rate-limiting mutations in human CRC occurs in the adenomatous polyposis coli (APC) gene. To identify mutations that cooperate with mutant APC, we performed a forward genetic screen in mice carrying a mutant allele of Apc (ApcMin) using Sleeping Beauty (SB) transposon-mediated mutagenesis. ApcMin SB-mutagenized mice developed three times as many polyps as mice with the ApcMin allele alone. Analysis of transposon common insertion sites (CIS) identified the Apc locus as a major target of SB-induced mutagenesis, suggesting that SB insertions provide an efficient route to biallelic Apc inactivation. We also identified an additional 32 CIS genes/loci that may represent modifiers of the ApcMin phenotype. Five CIS genes tested for their role in proliferation caused a significant change in cell viability when message levels were reduced in human CRC cells. These findings demonstrate the utility of using transposon mutagenesis to identify low-frequency and cooperating cancer genes; this approach will aid in the development of combinatorial therapies targeting this deadly disease.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 2
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    Theoretical analysis of quantum ghost imaging through turbulence (2011)
    American Physical Society (APS)
    Details
    Publication Date: 2011-10-06
    Description: Author(s): Kam Wai Clifford Chan, D. S. Simon, A. V. Sergienko, Nicholas D. Hardy, Jeffrey H. Shapiro, P. Ben Dixon, Gregory A. Howland, John C. Howell, Joseph H. Eberly, Malcolm N. O’Sullivan, Brandon Rodenburg, and Robert W. Boyd [Phys. Rev. A 84, 043807] Published Wed Oct 05, 2011
    Keywords: Quantum optics, physics of lasers, nonlinear optics, classical optics
    Print ISSN: 1050-2947
    Electronic ISSN: 1094-1622
    Topics: Physics
    Published by American Physical Society (APS)
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  • 3
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    Physics. Quantum weirdness in the lab (2007)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2007-09-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Boyd, Robert W -- Chan, Kam Wai Clifford -- O'Sullivan, Malcolm N -- New York, N.Y. -- Science. 2007 Sep 28;317(5846):1874-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Optics, University of Rochester, Rochester, NY 14627, USA. boyd@optics.rochester.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17901320" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    The 5300-year-old Helicobacter pylori genome of the Iceman (2016)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2016-01-09
    Description: The stomach bacterium Helicobacter pylori is one of the most prevalent human pathogens. It has dispersed globally with its human host, resulting in a distinct phylogeographic pattern that can be used to reconstruct both recent and ancient human migrations. The extant European population of H. pylori is known to be a hybrid between Asian and African bacteria, but there exist different hypotheses about when and where the hybridization took place, reflecting the complex demographic history of Europeans. Here, we present a 5300-year-old H. pylori genome from a European Copper Age glacier mummy. The "Iceman" H. pylori is a nearly pure representative of the bacterial population of Asian origin that existed in Europe before hybridization, suggesting that the African population arrived in Europe within the past few thousand years.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4775254/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4775254/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maixner, Frank -- Krause-Kyora, Ben -- Turaev, Dmitrij -- Herbig, Alexander -- Hoopmann, Michael R -- Hallows, Janice L -- Kusebauch, Ulrike -- Vigl, Eduard Egarter -- Malfertheiner, Peter -- Megraud, Francis -- O'Sullivan, Niall -- Cipollini, Giovanna -- Coia, Valentina -- Samadelli, Marco -- Engstrand, Lars -- Linz, Bodo -- Moritz, Robert L -- Grimm, Rudolf -- Krause, Johannes -- Nebel, Almut -- Moodley, Yoshan -- Rattei, Thomas -- Zink, Albert -- 2P50 GM076547/GM/NIGMS NIH HHS/ -- P50 GM076547/GM/NIGMS NIH HHS/ -- R01 GM087221/GM/NIGMS NIH HHS/ -- S10 RR027584/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2016 Jan 8;351(6269):162-5. doi: 10.1126/science.aad2545.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Mummies and the Iceman, European Academy of Bozen/Bolzano (EURAC), Viale Druso 1, 39100 Bolzano, Italy. frank.maixner@eurac.edu albert.zink@eurac.edu. ; Institute of Clinical Molecular Biology, Kiel University, Schittenhelmstrasse 12, 24105 Kiel, Germany. ; CUBE-Division of Computational Systems Biology, Department of Microbiology and Ecosystem Science, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria. ; Institute for Archaeological Sciences, University of Tubingen, Rumelinstrasse 23, 72072 Tubingen, Germany. Max Planck Institute for the Science of Human History, Kahlaische Strasse 10, 07745 Jena, Germany. ; Institute for Systems Biology, 401 Terry Avenue North, Seattle, WA 98109, USA. ; Scuola Superiore Sanitaria Provinciale "Claudiana," Via Lorenz Bohler 13, 39100 Bolzano, Italy. ; Department of Gastroenterology, Hepatology, and Infectious Diseases, Otto-von-Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany. ; Universite de Bordeaux, Centre National de Reference des Helicobacters et Campylobacters and INSERM U853, 146 rue Leo Saignat, 33076 Bordeaux, France. ; Institute for Mummies and the Iceman, European Academy of Bozen/Bolzano (EURAC), Viale Druso 1, 39100 Bolzano, Italy. ; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 141 83 Stockholm, Sweden. ; Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA 16802, USA. ; Robert Mondavi Institute for Food Science, University of California, Davis, CA 95616, USA. ; Department of Zoology, University of Venda, Private Bag X5050, Thohoyandou 0950, Republic of South Africa. Department of Integrative Biology and Evolution, Konrad Lorenz Institute for Ethology, University of Veterinary Medicine Vienna, Savoyenstrasse 1a, 1160 Vienna, Austria.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26744403" target="_blank"〉PubMed〈/a〉
    Keywords: Asia ; Chromosome Mapping ; DNA, Bacterial/genetics/isolation & purification ; Europe ; Genome, Bacterial/*genetics ; Helicobacter Infections/*microbiology ; Helicobacter pylori/*genetics/isolation & purification ; Human Migration ; Humans ; *Hybridization, Genetic ; Ice Cover/microbiology ; Mummies/microbiology ; Phylogeny ; Phylogeography ; Sequence Analysis, DNA ; Stomach/*microbiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Thermal ghost imaging with averaged speckle patterns (2012)
    American Physical Society (APS)
    Details
    Publication Date: 2012-12-18
    Description: Author(s): Petros Zerom, Zhimin Shi, Malcolm N. O'Sullivan, Kam Wai Clifford Chan, Molly Krogstad, Jeffrey H. Shapiro, and Robert W. Boyd We present theoretical and experimental results showing that a thermal ghost imaging system can produce images of high quality even when it uses detectors so slow that they respond only to intensity-averaged (that is, “blurred”) speckle patterns, as long as the collected signal variation is predomin... [Phys. Rev. A 86, 063817] Published Mon Dec 17, 2012
    Keywords: Quantum optics, physics of lasers, nonlinear optics, classical optics
    Print ISSN: 1050-2947
    Electronic ISSN: 1094-1622
    Topics: Physics
    Published by American Physical Society (APS)
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  • 6
    Electronic Resource
    Electronic Resource
    Cyclopropamitosenes, novel bioreductive anticancer agents. Synthesis of 7-methoxycyclopropamitosene and related indolequinones
    Amsterdam : Elsevier
    Tetrahedron 50 (1994), S. 7657-7674 
    Details
    ISSN: 0040-4020
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0040-4020(01)90492-2
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Indoloquinones - 3. Palladium-promoted synthesis of hydroxy-substituted 5-Cyano-5H-benzo[b]carbazole-6, 11-diones
    Amsterdam : Elsevier
    Tetrahedron 50 (1994), S. 10893-10908 
    Details
    ISSN: 0040-4020
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0040-4020(01)85701-X
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  • 8
    Electronic Resource
    Electronic Resource
    Harlequin colour in the Great Dane dog (1988)
    Springer
    Genetica 78 (1988), S. 215-218 
    Details
    ISSN: 1573-6857
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Breeding data from Eire and Great Britain confirm the hypothesis of Sponenberg (1985) that the harlequin colour of the Great Dane breed of dog is due the combined action of a dominant gene H with the merle gene M in the genotype H+M +. The typical bluish coloration induced by M is modified to white by the action of H. The H gene is a prenatal lethal when homozygous HH and this study offers clear indication that the heterozygous H + interacts with M to reduce the viability of white merle homozygotes H+MM.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00055640
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  • 9
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    Reticulon-like-1, the Drosophila orthologue of the Hereditary Spastic Paraplegia gene reticulon 2, is required for organization of endoplasmic reticulum and of distal motor axons (2012)
    Oxford University Press
    Details
    Publication Date: 2012-07-10
    Description: Several causative genes for hereditary spastic paraplegia encode proteins with intramembrane hairpin loops that contribute to the curvature of the endoplasmic reticulum (ER), but the relevance of this function to axonal degeneration is not understood. One of these genes is reticulon2 . In contrast to mammals, Drosophila has only one widely expressed reticulon orthologue, Rtnl1 , and we therefore used Drosophila to test its importance for ER organization and axonal function. Rtnl1 distribution overlapped with that of the ER, but in contrast to the rough ER, was enriched in axons. The loss of Rtnl1 led to the expansion of the rough or sheet ER in larval epidermis and elevated levels of ER stress. It also caused abnormalities specifically within distal portions of longer motor axons and in their presynaptic terminals, including disruption of the smooth ER (SER), the microtubule cytoskeleton and mitochondria. In contrast, proximal axon portions appeared unaffected. Our results provide direct evidence for reticulon function in the organization of the SER in distal longer axons, and support a model in which spastic paraplegia can be caused by impairment of axonal the SER. Our data provide a route to further understanding of both the role of the SER in axons and the pathological consequences of the impairment of this compartment.
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
    Published by Oxford University Press
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  • 10
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    Improved electrical mobility in highly epitaxial La:BaSnO3 films on SmScO3(110) substrates (2014)
    American Institute of Physics (AIP)
    Details
    Publication Date: 2014-08-07
    Description: Heteroepitaxial growth of BaSnO 3 and Ba 1−x La x SnO 3 (x = 7%) lanthanum doped barium stannate thin films on different perovskite single crystal (SrTiO 3 (001) and SmScO 3 (110)) substrates has been achieved by pulsed laser deposition under optimized deposition conditions. X-ray diffraction measurements indicate that the films on either of these substrates are relaxed due to the large mismatch and present a high degree of crystallinity with narrow rocking curves and smooth surface morphology while analytical quantification by proton induced X-ray emission confirms the stoichiometric La transfer from a polyphasic target, producing films with measured La contents above the bulk solubility limit. The films show degenerate semiconducting behavior on both substrates, with the observed room temperature resistivities, Hall mobilities, and carrier concentrations of 4.4 mΩ cm, 10.11 cm 2 V −1 s −1 , and 1.38 × 10 20  cm −3 on SmScO 3 and 7.8 mΩ cm, 5.8 cm 2 V −1 s −1 , and 1.36 × 10 20  cm −3 on SrTiO 3 ruling out any extrinsic contribution from the substrate. The superior electrical properties observed on the SmScO 3 substrate are attributed to reduction in dislocation density from the lower lattice mismatch.
    Print ISSN: 0003-6951
    Electronic ISSN: 1077-3118
    Topics: Physics
    Published by American Institute of Physics (AIP)
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