Publication Date:
1990-11-02
Description:
The TFP1 gene of the yeast Saccharomyces cerevisiae encodes two proteins: the 69-kilodalton (kD) catalytic subunit of the vacuolar proton-translocating adenosine triphosphatase (H(+)-ATPase) and a 50-kD protein. The 69-kD subunit is encoded by the 5' and 3' thirds of the TFP1 coding region, whereas the 50-kD protein is encoded by the central third. Evidence is presented that both the 69-kD and 50-kD proteins are obtained from a single translation product that is cleaved to release the 50-kD protein and spliced to form the 69-kD subunit.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kane, P M -- Yamashiro, C T -- Wolczyk, D F -- Neff, N -- Goebl, M -- Stevens, T H -- GM38006/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1990 Nov 2;250(4981):651-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Molecular Biology, University of Oregon, Eugene 97403.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2146742" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
*Genes, Fungal
;
Protein Biosynthesis
;
*Protein Processing, Post-Translational
;
Proton-Translocating ATPases/*biosynthesis/genetics
;
RNA, Messenger/analysis
;
Rabbits
;
Saccharomyces cerevisiae/*enzymology
;
Vacuoles/*enzymology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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