Publication Date:
2007-05-05
Description:
Coronary heart disease (CHD) is a major cause of death in Western countries. We used genome-wide association scanning to identify a 58-kilobase interval on chromosome 9p21 that was consistently associated with CHD in six independent samples (more than 23,000 participants) from four Caucasian populations. This interval, which is located near the CDKN2A and CDKN2B genes, contains no annotated genes and is not associated with established CHD risk factors such as plasma lipoproteins, hypertension, or diabetes. Homozygotes for the risk allele make up 20 to 25% of Caucasians and have a approximately 30 to 40% increased risk of CHD.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711874/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711874/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McPherson, Ruth -- Pertsemlidis, Alexander -- Kavaslar, Nihan -- Stewart, Alexandre -- Roberts, Robert -- Cox, David R -- Hinds, David A -- Pennacchio, Len A -- Tybjaerg-Hansen, Anne -- Folsom, Aaron R -- Boerwinkle, Eric -- Hobbs, Helen H -- Cohen, Jonathan C -- HL-066681/HL/NHLBI NIH HHS/ -- HL-082896/HL/NHLBI NIH HHS/ -- R01 HL082896/HL/NHLBI NIH HHS/ -- R01 HL082896-02/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 2007 Jun 8;316(5830):1488-91. Epub 2007 May 3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Cardiology, University of Ottawa Heart Institute, Ottawa K1Y4W7, Canada. rmcpherson@ottawaheart.ca〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17478681" target="_blank"〉PubMed〈/a〉
Keywords:
Aged
;
*Alleles
;
Case-Control Studies
;
Chromosome Mapping
;
Chromosomes, Human, Pair 9/*genetics
;
Coronary Artery Disease/genetics
;
Coronary Disease/*genetics
;
Ethnic Groups/genetics
;
Female
;
Gene Frequency
;
Genes, p16
;
*Genetic Predisposition to Disease
;
Genetic Variation
;
Haplotypes
;
Humans
;
Linkage Disequilibrium
;
Male
;
Middle Aged
;
Oligonucleotide Array Sequence Analysis
;
*Polymorphism, Single Nucleotide
;
Proportional Hazards Models
;
RNA, Untranslated/genetics
;
Regulatory Elements, Transcriptional
;
Risk Factors
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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