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  • 1
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    Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-02-22
    Description: Receptor-interacting protein kinase 1 (RIPK1) and RIPK3 trigger pro-inflammatory cell death termed "necroptosis." Studies with RIPK3-deficient mice or the RIPK1 inhibitor necrostatin-1 suggest that necroptosis exacerbates pathology in many disease models. We engineered mice expressing catalytically inactive RIPK3 D161N or RIPK1 D138N to determine the need for the active kinase in the whole animal. Unexpectedly, RIPK3 D161N promoted lethal RIPK1- and caspase-8-dependent apoptosis. In contrast, mice expressing RIPK1 D138N were viable and, like RIPK3-deficient mice, resistant to tumor necrosis factor (TNF)-induced hypothermia. Cells expressing RIPK1 D138N were resistant to TNF-induced necroptosis, whereas TNF-induced signaling pathways promoting gene transcription were unperturbed. Our data indicate that the kinase activity of RIPK3 is essential for necroptosis but also governs whether a cell activates caspase-8 and dies by apoptosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Newton, Kim -- Dugger, Debra L -- Wickliffe, Katherine E -- Kapoor, Neeraj -- de Almagro, M Cristina -- Vucic, Domagoj -- Komuves, Laszlo -- Ferrando, Ronald E -- French, Dorothy M -- Webster, Joshua -- Roose-Girma, Merone -- Warming, Soren -- Dixit, Vishva M -- New York, N.Y. -- Science. 2014 Mar 21;343(6177):1357-60. doi: 10.1126/science.1249361. Epub 2014 Feb 20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiological Chemistry, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24557836" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Apoptosis ; Caspase 8/genetics/metabolism ; Cell Survival ; Embryo Loss ; Embryonic Development ; Enteritis/pathology ; Fas-Associated Death Domain Protein/metabolism ; Gene Knock-In Techniques ; Intestine, Large/pathology ; Intestine, Small/pathology ; Mice ; *Necrosis ; Receptor-Interacting Protein Serine-Threonine Kinases/antagonists & ; inhibitors/genetics/*metabolism ; Tumor Necrosis Factor-alpha/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Fibroblastic reticular cells enhance T cell metabolism and survival via epigenetic remodeling (2019)
    Springer Nature
    Details
    Publication Date: 2019
    Print ISSN: 1529-2908
    Electronic ISSN: 1529-2916
    Topics: Biology , Medicine
    Published by Springer Nature
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  • 3
    Electronic Resource
    Electronic Resource
    Stress-Relaxing Solids. Recoil Phenomena (1965)
    s.l. : American Chemical Society
    Industrial and engineering chemistry 4 (1965), S. 186-194 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/i160014a016
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  • 4
    Electronic Resource
    Electronic Resource
    Oxygen consumption ofParagnetina media (Walker): Light-dark effect on respiratory rates (1972)
    Springer
    Cellular and molecular life sciences 28 (1972), S. 1311-1312 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Résumé Le taux de consommation d'oxygène d'oxygène des Plécoptères (stonefly) fut étudié à différentes heures de la journée. On a déterminé en outre l'effet de la lumière et de l'obscurité sur la respiration de ces insects. La consommation d'oxygène fut significativement plus élevée dans l'obscurité.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01965314
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  • 5
    Electronic Resource
    Electronic Resource
    Presence of specialized cellular complexes in the tracheal gills of stonefly nymph,Paragnetina media (Walker) (1973)
    Springer
    Cellular and molecular life sciences 29 (1973), S. 848-850 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Résumé Les coupes ultraminces d'un filament trachéobranchial d'une nymphe de plécoptère ont rélévé dans l'épithélium branchial des complexes cellularies spécialisés. Ces complexes sont présents tout le long du bord du filament, juste au-dessous de la cuticule et n'avaient pas encore été observés chez les plécoptères. Ils ressemblen aux «cellules de chlore» des poissons et à celles des nymphes des éphémères.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01946324
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  • 6
    Electronic Resource
    Electronic Resource
    Approach to histological detection of metallo-proteins (1971)
    Springer
    Naturwissenschaften 58 (1971), S. 610-612 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Notes: Abstract By use of a special type of application, molybdenum-99 is incorporated into xanthine oxidase molecules. The dissemination of molybdenum-99 labeled xanthine oxidase can be demonstrated by autoradiography.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01185605
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  • 7
    Electronic Resource
    Electronic Resource
    Thermomagnetic effect in nickel: Effect of low-temperature aging and subsequent hydrogenation (1990)
    Springer
    Il nuovo cimento della Società Italiana di Fisica 12 (1990), S. 147-154 
    Details
    ISSN: 0392-6737
    Keywords: Viscosity and diffusion: experimental ; Electronic conduction in metals and alloys ; Treatment of materials and its effects on microstructure and properties
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Description / Table of Contents: Riassunto Campioni di fili di nickel sono invecchiati a bassa temperatura e quindi sottoposti a diffusione di idrogeno elettrolitica. L’effetto termomagnetico è stato misurato sia prima che dopo l’idrogenazione. Questi ultimi mostrano una piú regolare variazione che i precedenti (senza idrogenazione), indicando che i campioni idrogenati sono elettricamente piú omogenei a causa della presenza di idrogeno intrappolato in alcuni loci del reticolo.
    Abstract: Резюме Образцы никелевой проволоки стареют при низких температурах, а затем подвергаются электролитически диффузии водорода. Измеряется термомагнитный эффект до и после гидрогенизации. Образцы после гидрогенизации обнаруживают более регулярные изменения, чем образцы до гидрогенизации, что указывает на то, что гидрогенизированные образцы электрически более однородные, вследствие наличия водорода, захваченного в некоторые узлы решетки.
    Notes: Summary Samples of nickel wires were aged at low temperature, then subjected to hydrogen diffusion electrolytically. Thermomagnetic effect was measured both before and after hydrogenation. The latter samples show a more regular variation than the former ones (without hydrogenation), indicating that the hydrogen-treated samples are electrically more homogeneous due to the presence of hydrogen trapped at some lattice sites.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02450452
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  • 8
    Electronic Resource
    Electronic Resource
    Partial filling ofd-band of nickel on hydrogen diffusion (1987)
    Springer
    Il nuovo cimento della Società Italiana di Fisica 9 (1987), S. 55-60 
    Details
    ISSN: 0392-6737
    Keywords: Diffusion in solids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Description / Table of Contents: Riassunto Si osserva che la ricottura a bassa temperatura di filamenti di nickel impedisce il completo riempimento della bandad del nickel quando questo è soggetto a diffusione dell’idrogeno catodico. In un certo intervallo a bassa temperatura si verificano cambiamenti irreversibili nell’orientamento dei piani di superficie del nickel che persistono anche se la temperatura si alza fino alla temperatura ambiente.
    Notes: Summary It is seen that low-temperature annealing of nickel wires forbids the complete filling in of thed-band of nickel when the latter is subjected to cathodic-hydrogen diffusion. At a certain low-temperature range irreversible changes occur in the orientation of the surface planes of nickel which persist even if the temperature is raised to the room temperature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02453274
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  • 9
    Electronic Resource
    Electronic Resource
    Rearing and maintenance of plecopteran nymphs (1972)
    Springer
    Hydrobiologia 40 (1972), S. 51-53 
    Details
    ISSN: 1573-5117
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary A device for rearing and maintenance of Plecopterans was designed and constructed. This apparatus is satisfactory for rearing other aquatic species. A desired water temperature and current velocities can be achieved in the apparatus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00123591
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  • 10
    Electronic Resource
    Electronic Resource
    Some studies on the respiration of stonefly nymph, Paragnetina media (Walker) (1974)
    Springer
    Hydrobiologia 44 (1974), S. 37-41 
    Details
    ISSN: 1573-5117
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The gills of Paragnetina media function as true respiratory organs. The animals with all the thoracic gill removed did not respire more than a few minutes. The respiratory rates showed a correlation to the body weight.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00036155
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