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  • 1
    Publication Date: 2012-06-12
    Description: Statins, inhibitors of HMG CoA reductase, have pleiotropic effects independent of their capacity to lower cholesterol. Heme-oxygenase-1(HO-1) plays an important role as an anti-oxidant and anti-inflammatory enzyme. In the present study, we used NIH 3T3 cells which express HO-1 to investigate the molecular mechanisms of HO-1 induction by statins. Simvastatin or fluvastatin induced a significant increase in HO-1 protein expression and mRNA levels. Both statins stimulated activity of a mouse HO-1 promoter (-1287 bp to +73 bp)/ luciferase reporter gene, 3.25 ± 0.23 (Mean ± S.E.M., n= 15, p 〈 0.001, t-test) and 3.13 ± 0.33 (Mean ± S.E.M., n= 6, p 〈 0.001, t-test), respectively. This effect was more pronounced in the short proximal promoter than the full promoter of HO-1. Gel retardation experiments for C/EBP and USF DNA-binding activities using simvastatin- or fluvastatin-treated cells showed significant nuclear protein-DNA complexes which were supershifted with antibodies specific for C/EBP β and δ or USF-1 and USF-2. Point mutations of the proximal HO-1 promoter (-149bp to +73bp) for the myc/max which binds USF or the C/EBP binding sequences showed a reduction in statin-induced reporter activity whereas no role of the distal C/EBP binding elements located at -4kb was observed. Moreover, overexpression of mutated C/EBP β and USF factor or the siRNA for both factors supported a role of these transcription factors in statin-dependent induction of HO-1, with a clearer effect for C/EBP. J. Cell. Biochem. © 2012 Wiley Periodicals, Inc.
    Electronic ISSN: 0091-7419
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Published by Wiley
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  • 2
    Publication Date: 2021-10-28
    Description: The aim of this study is to compare the seismic response of reinforced concrete (RC) symmetric buildings, with a varied number of stories, strengthening with three types of passive energy dissipation systems, as tuned mass dampers, viscous dampers, and friction dampers. The paper presents an overview of design optimization with the object of minimizing certain functions: (i) the maximum displacement at the top of the structures, (ii) the base shear loads, and (iii) the maximum interstory drift. The objective functions were evaluated in three residents’ buildings (a four-story building, a nine-story building, and a sixteen-story building) subjected to seven (real and artificial) seismic recorded accelerograms. For this purpose, 94 nonlinear dynamic analyses were carried out. The effects of each strengthening solution are presented, and from this innovative comparison (optimal design, three different passive energy systems, three different story numbers), further useful results were observed. The outcomes of the study show the effectiveness of a tuned mass damper (TMD) system, and how it might be better for tall and flexible structures than for stiffer structures. However, the response of the pendulum tuned mass damper (TMD) configuration is better than the conventional one because it acts in all directions. The viscous dampers (VDs) provide a significant reduction for mid-rise buildings, while friction dampers (FDs) boost the performance of all structures under seismic action, especially in terms of displacement, and they are more suitable for low-rise buildings.
    Electronic ISSN: 2076-3417
    Topics: Natural Sciences in General
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