Publication Date:
2013-01-01
Description:
Henoch-Schönlein purpura (HSP) is a small-vessel vasculitis of autoimmune hypersensitivity, and renin-angiotensin system (RAS) regulates vascular homeostasis and inflammation with activation of cytokine release. Thus, we aimed to investigate the association between HSP andACE I/DandAGT M235Tpolymorphisms. Genotyping was determined by allele specific PCR and PCR-RFLP. We obtained a significant difference in genotype distribution (p= 0.003) and allele frequencies (p〈 0.001) ofACE I/Dpolymorphism between patients and controls, while no significant association was detected in genotype distribution (p〉 0.05) and allele frequencies (p〉 0.05) of theAGT M235Tpolymorphism. Risk assessment showed significant risk for HSP in the subjects both with the ID + DD genotype (p= 0.019, OR: 2.288, 95% CI: 1.136–4.609) and D allele (OR: D vs. I: 2.0528, 95% CI: 1.3632–3.0912,p= 0.001) while no significant risk was obtained for HSP in the subjects both with the MT + TT genotype (p= 0.312, OR: 1.3905, 95% CI: 0.7326–2.6391) and T allele (OR: T vs. M: 1.065, 95% CI: 0.729–1.557,p= 0.743). Furthermore, when patients were stratified by the presence of certain systemic complications of HSP, no significant association was detected withACE I/D, andAGT M235Tpolymorphisms. Our findings suggest thatACE I/Dpolymorphism is significantly associated with HSP susceptibility.
Print ISSN:
0278-0240
Electronic ISSN:
1875-8630
Topics:
Biology
,
Chemistry and Pharmacology
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