Publication Date:
2015-07-23
Description:
Article TGF-ß and IL-6 are the essential cytokines for mediating the differentiation of IL-17-producing CD4+ T helper cells (T H 17). Here, Yoon et al . provide more insights into this process and describe the opposing roles of TGFß-signalling intermediates Smad2 and Smad3 as STAT3 cofactors in Th17 differentiation. Nature Communications doi: 10.1038/ncomms8600 Authors: Jeong-Hwan Yoon, Katsuko Sudo, Masahiko Kuroda, Mitsuyasu Kato, In-Kyu Lee, Jin Soo Han, Susumu Nakae, Takeshi Imamura, Juryun Kim, Ji Hyeon Ju, Dae-Kee Kim, Koichi Matsuzaki, Michael Weinstein, Isao Matsumoto, Takayuki Sumida, Mizuko Mamura
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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