Publication Date:
2015-10-14
Description:
Article What causes hematopoietic stem cell loss of functionality? Here, Alvarez et al . show that loss of origin licensing factor MCM3 induces replicative stress (RS), causing aberrant erythrocyte maturation, but mice strains with higher tolerance to RS can overcome this defect. Nature Communications doi: 10.1038/ncomms9548 Authors: Silvia Alvarez, Marcos Díaz, Johanna Flach, Sara Rodriguez-Acebes, Andrés J. López-Contreras, Dolores Martínez, Marta Cañamero, Oscar Fernández-Capetillo, Joan Isern, Emmanuelle Passegué, Juan Méndez
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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