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  • 1
    ISSN: 1477-7274
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Medicine , Economics
    Notes: Purpose - The paper is targeted to health service management teams as an aid to understanding the relationship between investment in process redesign in a clinical laboratory environment and improved quality of service/increased clinical activity. Design/methodology/approach - An audit of the unit's serum screening capability was performed against the standards of the current UK allocation scheme for cadaveric kidneys. Based on findings of this audit the laboratory's serum screening protocol was redesigned involving development of a new testing strategy and introduction of novel methods. A concurrent review of the effects of this initiative in terms of cadaveric kidney offers received/transplant numbers was undertaken and a cost-benefit analysis made. Findings - An improved eligibility of the patient cohort for cadaveric kidney offers was obtained together with a reduced unexpected positive crossmatch rate. These factors have together contributed to an increase in transplant numbers at the centre. Significant cost benefits have been achieved Research limitations/implications - The relevance of the findings relating to patient eligibility for available cadaveric grafts is limited to organ-sharing schemes in which recipient sensitisation is considered as part of the allocation process. Originality/value - The experience reported demonstrates the necessity of assessing the clinical impact of changes in practice when judgements are being made regarding the costs of laboratory services. In this respect the paper is the first from within this discipline to make this association.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature genetics 5 (1993), S. 210-213 
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Following Medawar's demonstration of the genetic basis to organ transplant rejection, early pioneers of human clinical organ transplantation attempted to ensure success either by transplanting between genetically identical individuals or by suppressing the vigorous host immune response. Genetic ...
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 409 (1983), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 381 (1982), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1572-9761
    Keywords: cultural ecology ; settlement patterns ; landtype associations ; archaeology ; General Land Office surveyors' notes ; LandSAT ; digital elevation model
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The distribution of human occupation across a landscape provides informationabout how people use the landscape, about patterns of economic development,and about social interactions of human groups. When the distributions areexamined over several thousand years, we gain an evolutionary understanding,not only of the people and their cultural patterns, but also of physicallandscape development. The focus of this assessment was to examine andcompare settlement patterns of prehistoric, historic, and present timeperiods, based on known cultural sites in the Eastern Upper Peninsula ofMichigan, U.S.A., and to generate hypotheses about the interaction ofsettlement pattern and landscape change at multiple scales. Patterns ofsettlement among the three time periods were compared at three geographicscales: by subregional ecosystems, by landscape ecosystems and by terraincharacteristics. The Michigan Bureau of History database of archaeologicalsites was searched for prehistoric habitation sites of Middle or LateWoodland period (ca. 3000-300 years before present). Historic occupationswere drawn from pre-European settlement landscape data based on General LandOffice survey notes of the 1850s. We extracted “urban” categories from landcover classified from Landsat Thematic Mapper imagery to measure presentoccupations. Spatial patterns and dynamics of settlement areas in each timeperiod were examined using the ARC/INFO geographic information system (GIS).Results showed a tendency for settlement in all time periods on the bedrockand lowland landscape groups near Great Lakes shorelines, generally occupyingslopes less than two percent. The distribution of present occupations, interms of both slope aspect and geographic subregion (multi-scalar), wassimilar to the distribution of prehistoric occupations. Both prehistoric andpresent sites were primarily south facing and were frequently found alongGreen Bay and Lake Michigan shorelines.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Somatic cell and molecular genetics 6 (1980), S. 529-541 
    ISSN: 1572-9931
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Fourteen independent, spontaneously arising HLA-A1 and -B27 variant clones were isolated from the pseudodiploid B lymphoid line T5-1 by selection using A1 and B27 alloantiserum, respectively, and complement. T5-1 is heterozygous for the tightly linked loci HLA-DR, -B, and -A and probably for -C as well. Following recloning, each of the variants was tested for the HLA specificities of T5-1. None of these spontaneous variants had a genetic lesion which extended to the nearest flanking HLA marker, less than 1 cM distant. On the other hand, a variant isolated from mutagenized cells had a lesion which extended completely through one HLA region in cis, suggesting that haploid expression in the HLA region is compatible with viability, that there are no recessive lethals in the opposite HLA region, and that spontaneously arising variants with extended lesions could have been recovered had they occurred. From these results, we conclude that extended genetic lesions of 0.8 cM or longer contribute less than 10% to the overall rate of spontaneous variation for HLA alleles, which we previously estimated at about 5×10 −7 per cell per generation.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 138 (1989), S. 247-256 
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Cell surface ligand-receptor interactions play a central role in the regulation and expression of macrophage function. Included among these macrophage membrane receptors are the β-adrenergic and opioid receptors. We studied the abilities of epinephrine, met-enkephalin, forskolin, and adenosine 3′:5′ cyclic monophosphate (cAMP) analogues to affect macrophage morphology, spreading, and adherence. Cell spreading was quantitated by measuring the perimeters of adherent cell images recorded by videomicroscopy. Epinephrine induced a dose-dependent decrease in macrophage spreading; at 10-5 M epinephrine the mean perimeter was 10.4 ± 0.3μm in comparison to 15.0 ± 1.0 μm for controls. The inhibition of spreading can be blocked by the antagonist propranolol. On the other hand, met-enkephalin induced a dose-dependent increase in macrophage spreading, with a perimeter of 18.5 ± 1.0 μm at 10-8 M. Since catecholamines and opioids are simultaneously released from chromaffin cells of the adrenal, we examined the combinative effects due to treatment with both ligands. When macrophages were exposed to 10-5 M epinephrine and 10-8 M met-enkephalin, cell morphology and spreading were indistinguishable from that due to 10-5 M epinephrine alone. The epinephrine dose-response curve in the presence of 10-8 M met-enkephalin, was similar to that of epinephrine alone. The β-adrenergic receptor is apparently capable of diminishing or abrogating the opioid receptor signal(s). These combinative and epinephrine-mediated effects may be at least partially accounted for by the action of cAMP. Forskolin and the cAMP analogues N6 -2′-O-dibutyryladenosine 3′:5′ cyclic monophosphate (dbcAMP) and 8-bromoadenosine 3′:5′ cyclic monophosphate (Br-cAMP) affected cell morphology and spreading in the same fashion as epinephrine. These differences in morphology and spreading behavior were accompanied by changes in the distribution of F-actin, as judged by phalladicin staining and fluorescence microscopy. We suggest that cAMP and microfilaments play important roles in receptor-mediated neuroregulation of macrophage function.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Bioelectromagnetics 12 (1991), S. 57-66 
    ISSN: 0197-8462
    Keywords: electromagnetic fields ; occupation ; brain tumor risk ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: To investigate the association between occupational exposure to low-frequency electric and magnetic (EM) fields and risk of brain tumors, a study was performed in Los Angeles County on 272 male adults with primary intracranial gliomas or meningiomas and 272 neighborhood controls. Complete occupational histories were collected. Risk associated with employment for more than 10 years in jobs that are presumed to entail exposure to EM fields was computed for various histological groupings. A nonsignificantly elevated risk of 1.7 was found for gliomas (all types pooled: 95% confidence interval 0.7-4.4), and a nonsignificantly reduced risk of 0.3 (95% confidence interval 0.03-3.2) was found for meningiomas. For astrocytomas, which form a subtype of the gliomas, a significantly elevated risk of 10.3 (95% confidence interval 1.3-80.8) was found; a significant upward trend (P = .01) of tumor incidence with increasing length of employment was observed. Most astrocytoma patients who worked in occupations involving exposure to EM fields were electricians or electrical engineers.
    Additional Material: 4 Tab.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Bioelectromagnetics 9 (1988), S. 207-213 
    ISSN: 0197-8462
    Keywords: electric blankets ; leukemia risk ; electric fields ; magnetic fields ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: In a case-control study of adult acute and chronic myelogenous leukemia in Los Angeles County, we tested the hypothesis that excess exposure to electromagnetic fields from electric blankets was associated with risk of leukemia. We did this by studying 116 cases of acute myelogenous leukemia (AML) and 108 cases of chronic myelogenous leukemia (CML) along with matched neighborhood controls. The cases and controls were queried as to electric blanket use and the risks computed. For AML the risk was 0.9 (95% CI 0.5-1.6) and for CML the risk was 0.8 (95% CI 0.4-1.6). Cases did not differ from controls by duration of use, year of first regular use, year since last use, or socioeconomic status. Our best estimates of exposure indicate that electric blanket use increases overall exposure to electric fields by less than 50% and magnetic fields by less than 100%. We conclude that there is no major leukemogenic risk associated with electric blanket use in Los Angeles County.
    Additional Material: 3 Tab.
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  • 10
    Publication Date: 2012-05-03
    Description: By July 2011, North American carsharing had grown to an industry of nearly 640,000 members since its inception on the continent more than 15 years ago. Carsharing engenders changes in member travel patterns both towards and away from public transit and non-motorized modes. This study, which builds on the work of two previous studies, evaluates this shift in travel based on a 6281 respondent survey completed in late-2008 by members of major North American carsharing organizations. Across the entire sample, the results showed an overall decline in public transit use that was statistically significant, as 589 carsharing members reduced rail use and 828 reduced bus use, while 494 increased rail use and 732 increased bus use. Thus for every five members that use rail less, four members use rail more, and for every 10 members that ride a bus less, almost nine members ride the bus more. The people increasing and decreasing their transit use are fundamentally different in terms of how carsharing impacts their travel environment. This reduction, however, is also not uniform across all organizations; it is primarily driven by a minority (three of eleven) of participating organizations. At the same time, members exhibited a statistically significant increase in travel by walking, bicycling, and carpooling. Across the sample, 756 members increased walking versus a 568 decrease, 628 increased bicycling versus a 235 decrease, and 289 increased carpooling versus a decrease of 99  study participants. The authors found that 970 members reduced their auto commuting to work, while 234 increased it. Interestingly, when these shifts are combined across modes, more people increased their overall public transit and non-motorized modal use after joining carsharing than decreased it. Data collected on the commute distance of respondents found that carsharing members tend to have shorter commutes than most people living in the same zip code. The analysis also evaluates the distribution of residential population density of members and its association with average changes in driving. The analysis finds that average driving reductions are consistent across population densities up to 10,000 persons/square kilometer but become more varied at higher densities.
    Electronic ISSN: 1996-1073
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Published by MDPI Publishing
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