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  • 1
    Keywords: Conservation biology. ; Ecology . ; Freshwater ecology. ; Marine ecology. ; Oceanography. ; Biogeography. ; Biodiversity. ; Conservation Biology. ; Freshwater and Marine Ecology. ; Biooceanography. ; Biogeosciences. ; Biodiversity. ; Ecology.
    Description / Table of Contents: An integrated conservation vision for Chilean Patagonia -- Global change and acceleration of anthropic pressures on Patagonian ecosystems -- Representativeness assessment and identification of priorities for the protection of terrestrial ecosystems in Chilean Patagonia -- Terrestrial protected areas in Chilean Patagonia: characterization, historical evolution, and management -- Conserving the origin of rivers: intact forested watersheds in western Patagonia -- Peatlands in Chilean Patagonia: distribution, biodiversity, ecosystem services, and conservation -- Steppe ecosystems in Chilean Patagonia: distribution, climate, biodiversity, and threats to their sustainable management -- Coastal-marine protection in Chilean Patagonia: historical progress, current situation, and challenges -- Marine mammals and seabirds of Chilean Patagonia: focal species for the conservation of marine ecosystems -- Hard bottom macrobenthos of Chilean Patagonia: emphasis on conservation of subltitoral invertebrate and algal forests -- Fisheries and marine conservation in Chilean Patagonia -- Aquaculture and its impacts on the conservation of Chilean Patagonia -- Ecological connections across the marine-terrestrial interface in Chilean Patagonia -- A conservation assessment of freshwater ecosystems in southwestern Patagonia -- Chilean Patagonian glaciers and environmental change -- Conservation and indigenous people in Chilean Patagonia -- Drivers of change in ecosystems of Chilean Patagonia: current and projected trends -- Analysis of tourism development linked to protected areas in Chilean Patagonia.
    Abstract: Chilean Patagonia, located at the southwestern tip of South America, is one of the last regions on earth where highly intact environments predominate. With a coastline that extends along some 100,000 km of fjords, channels, and islands, it has one of the world´s most extensive marine-terrestrial interfaces. Local place-based and Indigenous cultures and management practices are a vital presence across the region, while the long and rich history of conservation efforts have resulted in officially protected areas covering over 50% of the land and 41% of the coastal-marine area. However, Chilean Patagonia is increasingly facing anthropogenic pressures associated with increased infrastructure and access, salmon aquaculture, extractive industries, and the spread of invasive exotic species. Despite widespread recognition that Chilean Patagonia represents a unique global reservoir of socio-natural heritage, to date there has been no region-wide assessment of the scientific evidence of the conservation status of its ecosystems or the priorities for their effective conservation. Conservation in Chilean Patagonia: Assessing the state of knowledge, opportunities, and challenges is the first book to gather and synthesize the available scientific and socio-environmental information related to Patagonian conservation. It presents the collaborative work of 68 researchers and local experts, representing a range of specialties and perspectives, including: biology, ecology, socio-ecology, fisheries, aquaculture, anthropology, economics, geography, tourism, cryosphere, oceanography, climate and global change. The book’s 18 chapters focus on the status of key ecosystems and conservation tools, and provide recommendations toward the construction of a renewed, inclusive, and integrated conservation agenda for the Chilean Patagonian region. It provides an essential primer for anyone interested in the future of this ecologically vital region, as well as lessons on interdisciplinary collaboration and integrated analysis of conservation issues useful for conservation practitioners and scholars. This is an open access book. This book is a translation of an original Spanish edition. The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com). A subsequent human revision was done primarily in terms of content, so that the book will read stylistically differently from a conventional translation.
    Type of Medium: Online Resource
    Pages: XXIX, 504 p. 112 illus., 105 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031394089
    Series Statement: Integrated Science, 19
    DDC: 333.9516
    Language: English
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  • 2
    Call number: PIK Q 200-99-0044
    In: ZIB-Report SC
    Type of Medium: Monograph available for loan
    Pages: 9 p.
    Series Statement: ZIB-Report SC 98-22
    Location: A 18 - must be ordered
    Branch Library: PIK Library
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  • 3
    Publication Date: 2020-10-09
    Description: The aim of this transversal study was to describe the virological and immunological features of HIV-infected youths transferred from pediatric to adult care units since 1997 vs. the non-transferred patients from the Madrid Cohort of HIV-infected children and adolescents in Spain. We included 106 non-transferred and 184 transferred patients under clinical follow-up in 17 public hospitals in Madrid by the end of December 2017. Virological and immunological outcomes were compared in transferred vs. non-transferred patients. ART drug resistance mutations and HIV-variants were analyzed in all subjects with available resistance pol genotypes and/or genotypic resistance profiles. Among the study cohort, 133 (72.3%) of 184 transferred and 75 (70.7%) of 106 non-transferred patients had available resistance genotypes. Most (88.9%) of transferred had ART experience at sampling. A third (33.3%) had had a triple-class experience. Acquired drug resistance (ADR) prevalence was significantly higher in pretreated transferred than non-transferred patients (71.8% vs. 44%; p = 0.0009), mainly to NRTI (72.8% vs. 31.1%; p 
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Published by Springer Nature
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Freshwater biology 45 (2000), S. 0 
    ISSN: 1365-2427
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: 1. Seasonal field data showed a positive correlation between the tail spine length of Daphnia hyalina×galeata and the density of the copepod Acanthocyclops robustus. Laboratory experiments were designed to assess the mechanisms underlying the induction of tail spine elongation and to test whether this morphology reduced predation on Daphnia juveniles. 
2. Both the elongated tail spine morph and control spine morph produced progeny with elongated tail spine when exposed to copepods. Instar increments, calculated from individual body length, showed that individual growth decreased in the presence of copepods. This decrease in individual growth was less pronounced in spined morphs relative to control morphs. 
3. Copepods exhibited significantly higher feeding rates on control morph juveniles compared to elongated tail spine morph juveniles. 
4. All Daphnia matured at instar 5 even though the control morph neonates took 24–30 more hours to mature in the presence of copepods than in the absence of copepods. Enlarged body and spine lengths of progeny coincided with reduced progeny number during the first six reproductive instars. The disadvantage of the reduced offspring number produced per female was balanced by enhanced survivorship of progeny subjected to copepod predation.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1573-5117
    Keywords: Acanthocyclops robustus ; cladocerans ; Anomopoda ; tail spine elongation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Daphnia hyalina is a cladoceran present throughthe whole year except for late summer in Maranhão,a meso-eutrophic reservoir in central Portugal. Apartfrom the influence of food, both vertebrate andinvertebrate predation pressures seem to have aneffect on D. hyalina population dynamics.Enclosure experiments were designed to assess therelative importance of both types of predation. Afterthe summer crash, D. hyalina reached highernumbers in the fishless enclosures than in the lakedespite of high predation pressure upon juveniles byAcanthocyclops robustus. Fish predation upon thelargest individuals, especially large egg bearingfemales, was responsible for the lower fertility ofthe open water population when compared with theenclosure population. In the enclosures an increase intail spine length was observed. The longer tail spineprobably offered protection from copepod predation,allowing at least some of the juveniles to coexistwith their potential predator and reach the adultstage, less susceptible to copepod predation.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1573-5125
    Keywords: birth rate variation ; fecundity ; Mesostoma sp.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Daphnia hyalina × galeata in Castelo-do-Bode Reservoir was regulated mainly by food availability during the summers of 1993 and 1994. Because of high temperatures and low rainfall in 1994, the reservoir was, apparently, more eutrophic relatively to 1993. Higher chlorophyll-a concentrations and higher clutch size in 1994 suggest that Daphnia population benefited from better feeding conditions in 1994. The analysis of the contributions from fecundity and adult proportion to birth rate variation suggest that vertebrate predation and predation by copepods were negligible factors as population organisers. A general decrease in the abundance of large crustaceans during the periods of high density of typhloplanid flatworms, in both years, points to the importance of flatworm predation on zooplankton. A decrease in the number of individuals in all Daphnia size classes was observed during the periods of flatworms population increase.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1573-5125
    Keywords: Copepoda ; flatworms ; food limitation index ; mate limitation index ; Mesostoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract We investigated the population dynamics of Copidodiaptomus numidicus (Copepoda: Calanoida) and Thermocyclops dybowskii (Copepoda: Cyclopoida) in Castelo-do-Bode Reservoir (Portugal). Both species in the reservoir were regulated mainly by food availability during the summers of 1993 and 1994. C. numidicus was always more abundant than T. dybowskii in the reservoir. C. numidicus produced two generations during the sampling period of both years whereas T. dybowskii produced two and three generations in 1993 and 1994, respectively. Because of high temperatures and low rainfall in 1994, the reservoir was more eutrophic than in 1993. Higher clutch size and a higher percentage of ovigerous females suggest that both species were benefiting from better feeding conditions in 1994. Despite this, population growth was reduced in 1994 relatively to 1993. Vertebrate predation and predation by copepods seem to have been minor factors in explaining this decline. However, the presence of Mesostoma sp. in the reservoir may have contributed to the reduction of both copepod populations during specific periods in 1994 although the calanoid was more affected than the cyclopoid by this predation.
    Type of Medium: Electronic Resource
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  • 8
    Publication Date: 2015-12-03
    Description: INTRODUCTION Anemia is the most frequent cytopenia in lower-risk MDS. Erythropoietic-stimulating agents (ESAs) are commonly used in these patients. The use of ÒclassicalÓ parameters (EPO and ferritin levels) and the revised IPSS (IPSS-R) has been proposed1 (SantiniÕs score) to predict response to ESAs and overall survival (OS) among patients with lower risk MDS by IPSS and a favorable Nordic group score2. OBJECTIVES The main objective of the study was to evaluate overall response rate (ORR) to ESAs and OS according to the proposed SantiniÕs score in an independent and large cohort of anemic lower risk MDS patients receiving treatment with ESAs. METHODS Data from 530 anemic patients with low/int1 risk IPSS de novo MDS (according to FAB and WHO criteria) and sufficient follow-up data available were recorded in Spresas3 (SPanish Registry of Erythropoietic Stimulating Agents Study from GESMD). Two hundred and twenty six patients (42.6% of the patients) were selected according to specific criteria regarding the published SantiniÕs score1: Hb level 350 ng/mL(=1) and IPSS-R very low=0, low=1, intermediate=2 and high=3) yielded a score ranging from 0 to 5. ESAs response rate and overall survival were analysed according to these score. Response to treatment was evaluated according to IWG 2006 response criteria and a multivariate logistic regression analysis was used to identify independent predictors of erythroid response (ER). OS were defined as the time between diagnosis and the corresponding event or last follow up (Feb 2015) and were analyzed using univariable and multivariable Cox proportional hazards regression methods. RESULTS Median age was 77 years (interquartile range [IQR] 25%-75%: 71-83 y), median Hb level at start of treatment was 10 g/dL (IQR25-75: 9-10), median EPO level was 90 (IQR25-75: 27,25-108) and median ferritin level was 338,5 (IQR25-75: 146,5-568,75). Among 139 patients with this data available, 85 patients (61,1%) were RBC transfusion dependent before ESAs treatment. Median time from diagnosis to ESAs treatment was 82 (IQR25-75: 27-353) days. According to the IPSS, 68.6% (N=155) and 31.4% (N=71) were in low and Int-1 risk groups, respectively. Regarding IPSS-R, 23% (N=52), 66.8% (N=151), 9.7% (N=22) and 0.4% (N=1) were in very low, low, intermediate and high risk, respectively. ORR to ESA treatment was 71.2% (N=161), with a median duration of response of 2.06 years. Prognosis factors of ER showed a trend toward to a higher ER among patients in the lower IPSS-R (P〉0.05), low IPSS (p=0.039) and lower EPO levels (p
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
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  • 9
    Publication Date: 2012-11-16
    Description: Abstract 3142 Background: Recent studies indicate that the use of highly effective rituximab (R)-containing primary therapy in Diffuse Large B-cell Lymphoma (DLBCL) makes it more difficult to salvage patients who are refractory or who relapse. To date, peripheral-blood autologous stem-cell transplantation (PBASCT) is the reference treatment for these patients, but the impact of previous exposure to R on the ulterior results of ASCT is still unknown. Patients and methods: We have retrospectively analysed 252 patients (pts) with DLBCL or grade 3B follicular lymphoma with relapsed or refractory disease after at least one rituximab-containing regimen (“R+” group) who received PBASCT in 17 GELTAMO centers, in comparison to a control group of 127 patients who received APBSCT as salvage therapy without previous exposure to rituximab (“R-” group). Patients with refractory disease at transplant were excluded from the analysis. Results: No significant differences between R+ and R- groups were found with respect to age-adjusted IPI at transplant, disease status at salvage therapy and at transplant, nor number or prior chemotherapy regimens. More patients in the R+ group were ≥60 years (30% vs 19%, p=.02). Complete response (CR) (69% v 70%) and overall response (84% v 83%) rates to PBASCT were similar in R+ and R- groups. In multivariate analysis, factors with significant influence on CR rates were: age-adjusted IPI at diagnosis (
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
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  • 10
    Publication Date: 2014-12-06
    Description: Background: Clinical, morphological and genetic characteristics of chronic myelomonocytic leukemia (CMML) are heterogeneous and vary from a myelodysplastic predominant profile to a myeloproliferative one. CMML has a highly variable course, with a median overall survival (OS) of 20 months and 15-30% of progression to acute myeloid leukemia (AML). Cytogenetic abnormalities are present in only 20-40% of cases. CMML-specific cytogenetic risk classification stratifies karyotypes into three groups: low risk (normal karyotype and isolated loss of Y chromosome, -Y), poor risk (trisomy 8, monosomy 7, 7q deletion and complex karyotype) and intermediate risk (all other chromosomal abnormalities). According to this model, 65-85% of patients fall into the low risk cytogenetic category. The aim of this study was to characterize type, frequency and prognostic impact of cytogenetic alterations detected by SNP arrays (SNP-A) in a series of 128 patients with CMML and low risk cytogenetic features or no metaphases. Methods: A retrospective study was performed on 128 patients with CMML. Cases with normal karyotype (n=120), isolated -Y (n=4) and no metaphases (n=4) were selected. Median age at diagnosis was 73 years (range 39-98), there was a 2.4:1 male predominance and 22.4% (28/125) of cases progressed to AML. Median follow up of patients was 26 months (range 1-115). Morphological WHO subtypes were CMML-1 in 104 (81%) cases and CMML-2 in 24 (19%). According to the FAB criteria 82 (64%) cases were included in the myelodysplastic variant (CMML-MD) and 46 (36%) in the myeloproliferative one (CMML-MP). High density SNP-A (Cytoscan HD, Affymetrix) were performed using DNA extracted from bone marrow (n=124) or peripheral blood (n=4) samples at diagnosis. The statistical analysis was performed with SPSS. Kaplan-Meier method was used for OS and progression-free survival (PFS) analysis and log-rank test was used for comparisons between groups. Results: SNP-A revealed novel chromosomal alterations (copy number alterations, CNA, and loss of heterozygosity, LOH) in 66% (85/128) of cases. Among the abnormal cases (CNA plus LOH), 1 alteration was detected in 65% (55/85) of cases, 2 in 20% (17/85) and ≥3 in 15% (13/85). The median size of the affected genome for CNA and LOH was 759 Kb (range 0-142Mb). CNA were detected in 38% (48/128) of cases, most of them being gains and losses smaller than 10Mb. Only 7 CNA were larger than 10Mb, four of them corresponded to patients with isolated -Y and three were novel alterations that had not been detected by conventional G-banding cytogenetics. Most affected regions (detected in 5 cases) were gains in chromosomes 3q, 8p and 21q as well as losses in chromosomes 10q and 12p. LOH were detected in 39% (50/128) of patients. Interstitial LOH larger than 〉25Mb were detected in 30% (39/128) of cases. Recurrent interstitial LOH were detected in: 4q24-4q35 region (12 cases), involving TET2 gene, which is mutated in 40-50% of CMML; and in chromosome 11 (9 cases), 7 of which included 11q13.3-11q25 region, involving CBLgene, mutated in 5-20% of CMML. Although the number of total alterations (1, 2 or ≥3) do not have a survival impact, we found a significant correlation between the size of the affected genome (≥30 Mb, including CNA and LOH) and a poorer OS (OS at 3 years 26% vs. 46%, P=0.039). Regarding type of alterations, cases with interstitial LOH had lower OS than cases without LOH (OS at 3 years 19% vs. 45%, P=0.049). Cases with high risk alterations as defined by CMML-specific cytogenetic risk classification (losses in 7q, gains in 8q and ≥3 CNA) had lower PFS than patients with other aberrations (PFS at 1 year 76% vs. 93%, P=0.036), although statistical significance was not reached for OS (OS at 3 years, 27% vs.49%, P=0.096). Conclusions: SNP-A in CMML patients with low risk cytogenetic features or no metaphases has led to the detection of chromosomal alterations in 66% of cases. Using this technique the prognosis can be better defined, and we can detect a group of patients with worse outcome who could be considered for more intensive treatment. Acknowledgments: Instituto de Salud Carlos III, Ministerio de Sanidad y Consumo, Spain (PI 11/02519; PI 11/02010); RTICC, FEDER (RD12/0036/0044; RD12/0036/0014); 2014 SGR225 (GRE) Generalitat de Catalunya; Fundació Internacional Josep Carreras, Obra Social “La Caixa” and Celgene Spain; NHRI-EX103-10003NI, Taiwan. Footnote: Francesc Solé and Lurdes Zamora contributed equally Disclosures Xicoy: Celgene: Honoraria. Sole:Celgene: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding.
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
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