ISSN:
0021-9304
Keywords:
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Medicine
,
Technology
Notes:
The interaction of 111Indium-labeled platelets, and other blood components with the luminal surface of polydimethylsiloxane (PDMS) and low-density polyethylene (LDPE) was determined using an ex vivo arteriovenous shunt in the baboon. Both PDMS and LDPE showed little platelet accumulation at either high (200 cc/min) or low (25 cc/min) flow rates. PDMS accumulated more platelets at low than at high flow. When the surfaces of PDMS and LDPE were examined under scanning electron microscopy after 2.5 h of flow in the shunt circuit, red and white blood cells were attached. Platelets appeared to be confined to patchy areas covered by a fibrinlike network. The low platelet reactivity of LDPE and PDMS suggests their potential use as coatings for conventional, more platelet reactive, vascular graft materials.
Additional Material:
10 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jbm.820190509
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