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  • 1
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    Establishment of environmentally sensitive DNA methylation states in the very early human embryo (2018)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2018-07-12
    Description: The molecular mechanisms responsible for the developmental origins of later disease are currently unknown. We previously demonstrated that women’s periconceptional nutrition predicts their offspring’s DNA methylation at metastable epialleles (MEs). We present a genome-wide screen yielding 687 MEs and track their trajectories across nine developmental stages in human in vitro fertilization embryos. MEs exhibit highly unusual methylation dynamics across the implantation-gastrulation transition, producing a large excess of intermediate methylation states, suggesting the potential for differential programming in response to external signals. Using a natural experiment in rural Gambia, we show that genomic regions sensitive to season of conception are highly enriched for MEs and show similar atypical methylation patterns. MEs are enriched for proximal enhancers and transcription start sites and are influenced by genotype. Together, these observations position MEs as distinctive epigenomic features programmed in the early embryo, sensitive to genetic and periconceptional environment, and with the potential to influence phenotype.
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Coastal habitats shield people and property from sea-level rise and storms (2013)
    Springer Nature
    Details
    Publication Date: 2013-09-26
    Description: Extreme weather, rising seas and degraded coastal ecosystems all play a part in escalating the risks that coastal regions are exposed to. Now research into hazards facing the contiguous USA indicates that the likelihood and magnitude of losses can be reduced by intact reefs and coastal vegetation. Nature Climate Change 3 913 doi: 10.1038/nclimate1944
    Print ISSN: 1758-678X
    Electronic ISSN: 1758-6798
    Topics: Geosciences
    Published by Springer Nature
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  • 3
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    Using social media to quantify nature-based tourism and recreation (2013)
    Springer Nature
    Details
    Publication Date: 2013-10-18
    Description: Scientists have traditionally studied recreation in nature by conducting surveys at entrances to major attractions such as national parks. This method is expensive and provides limited spatial and temporal coverage. A new source of information is available from online social media websites such as flickr. Here, we test whether this source of “big data” can be used to approximate visitation rates. We use the locations of photographs in flickr to estimate visitation rates at 836 recreational sites around the world, and use information from the profiles of the photographers to derive travelers' origins. We compare these estimates to empirical data at each site and conclude that the crowd-sourced information can indeed serve as a reliable proxy for empirical visitation rates. This new approach offers opportunities to understand which elements of nature attract people to locations around the globe, and whether changes in ecosystems will alter visitation rates. Scientific Reports 3 doi: 10.1038/srep02976
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Published by Springer Nature
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  • 4
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    Quantifying variation in water column photosynthetic quotient with changing field conditions in Narragansett Bay, RI, USA (2012)
    Oxford University Press
    Details
    Publication Date: 2012-03-30
    Description: A photosynthetic quotient (PQ) for Narragansett Bay, RI, USA was calculated using concurrent 14 C and oxygen light–dark bottle primary production estimations. The current PQ (1.42 ± 0.09) was elevated over the PQ (1.24) calculated in a 1980's mesocosm experiment, stimulating a sensitivity analysis of physiological drivers of the PQ. We speculate that the factor that altered the PQ between surveys was wastewater treatment facility upgrades increasing NO 3 – effluent proportion from 10 to 40%.
    Print ISSN: 0142-7873
    Electronic ISSN: 1464-3774
    Topics: Biology
    Published by Oxford University Press
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  • 5
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    Segregation of antiferromagnetism and high-temperature superconductivity in Ca1−xLaxFe2As2 (2014)
    American Physical Society (APS)
    Details
    Publication Date: 2014-04-24
    Description: Author(s): Shanta R. Saha, T. Drye, S. K. Goh, L. E. Klintberg, J. M. Silver, F. M. Grosche, M. Sutherland, T. J. S. Munsie, G. M. Luke, D. K. Pratt, J. W. Lynn, and J. Paglione We report the effect of applied pressures on magnetic and superconducting order in single crystals of the aliovalent La-doped iron pnictide material Ca1−xLaxFe2As2. Using electrical transport, elastic neutron scattering, and resonant tunnel diode oscillator measurements on samples under both quasihy... [Phys. Rev. B 89, 134516] Published Wed Apr 23, 2014
    Keywords: Superfluidity and superconductivity
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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  • 6
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    A sheep and a metaphor (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-10-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Silver, Lee M -- New York, N.Y. -- Science. 2000 Feb 25;287(5457):1404-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11645195" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Experimentation ; Animal Welfare ; Animals ; Animals, Genetically Modified ; *Cloning, Organism ; Metaphor ; Methods
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Isolation of putative progenitor endothelial cells for angiogenesis (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-02-14
    Description: Putative endothelial cell (EC) progenitors or angioblasts were isolated from human peripheral blood by magnetic bead selection on the basis of cell surface antigen expression. In vitro, these cells differentiated into ECs. In animal models of ischemia, heterologous, homologous, and autologous EC progenitors incorporated into sites of active angiogenesis. These findings suggest that EC progenitors may be useful for augmenting collateral vessel growth to ischemic tissues (therapeutic angiogenesis) and for delivering anti- or pro-angiogenic agents, respectively, to sites of pathologic or utilitarian angiogenesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Asahara, T -- Murohara, T -- Sullivan, A -- Silver, M -- van der Zee, R -- Li, T -- Witzenbichler, B -- Schatteman, G -- Isner, J M -- 2824/PHS HHS/ -- 53354/PHS HHS/ -- 57516/PHS HHS/ -- New York, N.Y. -- Science. 1997 Feb 14;275(5302):964-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine (Cardiology), St. Elizabeth's Medical Center, Tufts University School of Medicine, 736 Cambridge Street, Boston, MA 02135, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9020076" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, CD34/analysis ; Biomarkers/analysis ; Cell Differentiation ; Cell Separation ; Cells, Cultured ; Endothelium, Vascular/chemistry/*cytology ; Flow Cytometry ; Hindlimb/blood supply ; Humans ; Ischemia/physiopathology ; Mice ; Mice, Inbred C57BL ; Mice, Nude ; Mice, Transgenic ; *Neovascularization, Physiologic ; Nitric Oxide Synthase/analysis ; Rabbits ; Receptor Protein-Tyrosine Kinases/analysis ; Receptors, Growth Factor/analysis ; Receptors, Vascular Endothelial Growth Factor ; Stem Cells/chemistry/*cytology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Universal symmetry-breaking dynamics for the Kerr interaction of counterpropagating light in dielectric ring resonators (2018)
    American Physical Society (APS)
    Details
    Publication Date: 2018-12-01
    Description: Author(s): Michael T. M. Woodley, Jonathan M. Silver, Lewis Hill, François Copie, Leonardo Del Bino, Shuangyou Zhang, Gian-Luca Oppo, and Pascal Del'Haye Spontaneous symmetry breaking is an important concept in many areas of physics. A fundamentally simple symmetry-breaking mechanism in electrodynamics occurs between counterpropagating electromagnetic waves in ring resonators, mediated by the Kerr nonlinearity. The interaction of counterpropagating l... [Phys. Rev. A 98, 053863] Published Fri Nov 30, 2018
    Keywords: Quantum optics, physics of lasers, nonlinear optics, classical optics
    Print ISSN: 1050-2947
    Electronic ISSN: 1094-1622
    Topics: Physics
    Published by American Physical Society (APS)
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  • 9
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    Netrins promote developmental and therapeutic angiogenesis (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-07-01
    Description: Axonal guidance and vascular patterning share several guidance cues, including proteins in the netrin family. We demonstrate that netrins stimulate proliferation, migration, and tube formation of human endothelial cells in vitro and that this stimulation is independent of known netrin receptors. Suppression of netrin1a messenger RNA in zebrafish inhibits vascular sprouting, implying a proangiogenic role for netrins during vertebrate development. We also show that netrins accelerate neovascularization in an in vivo model of ischemia and that they reverse neuropathy and vasculopathy in a diabetic murine model. We propose that the attractive vascular and neural guidance functions of netrins offer a unique therapeutic potential.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2577078/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2577078/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wilson, Brent D -- Ii, Masaaki -- Park, Kye Won -- Suli, Arminda -- Sorensen, Lise K -- Larrieu-Lahargue, Frederic -- Urness, Lisa D -- Suh, Wonhee -- Asai, Jun -- Kock, Gerhardus A H -- Thorne, Tina -- Silver, Marcy -- Thomas, Kirk R -- Chien, Chi-Bin -- Losordo, Douglas W -- Li, Dean Y -- R01 HL068873/HL/NHLBI NIH HHS/ -- R01 HL077671/HL/NHLBI NIH HHS/ -- R01 HL077671-03/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 2006 Aug 4;313(5787):640-4. Epub 2006 Jun 29.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Program in Human Molecular Biology and Genetics, University of Utah, Salt Lake City, UT 84112, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16809490" target="_blank"〉PubMed〈/a〉
    Keywords: Angiogenesis Inducing Agents ; Animals ; Cell Line ; Cell Movement ; Chemotaxis ; DNA, Complementary ; Diabetic Angiopathies/therapy ; Diabetic Neuropathies/therapy ; Embryo, Nonmammalian ; Endothelial Cells/*physiology ; Endothelium, Vascular/cytology ; Genetic Therapy ; Humans ; Ischemia/drug therapy ; Mice ; Muscle, Skeletal/blood supply ; *Neovascularization, Physiologic ; Nerve Growth Factors/genetics/pharmacology/*physiology ; Neural Conduction ; Receptors, Cell Surface/physiology ; Tumor Suppressor Proteins/genetics/pharmacology/*physiology ; Vascular Endothelial Growth Factor A/therapeutic use ; Zebrafish
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 10
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    The acquisition of sex (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-04-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Silver, L M -- New York, N.Y. -- Science. 1994 Apr 1;264(5155):116.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17778144" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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