Publication Date:
2000-09-08
Description:
During animal development, cells become progressively more restricted in the cell types to which they can give rise. In the central nervous system (CNS), for example, multipotential stem cells produce various kinds of specified precursors that divide a limited number of times before they terminally differentiate into either neurons or glial cells. We show here that certain extracellular signals can induce oligodendrocyte precursor cells to revert to multipotential neural stem cells, which can self-renew and give rise to neurons and astrocytes, as well as to oligodendrocytes. Thus, these precursor cells have greater developmental potential than previously thought.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kondo, T -- Raff, M -- New York, N.Y. -- Science. 2000 Sep 8;289(5485):1754-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Medical Research Council Developmental Neurobiology Programme, MRC Laboratory for Molecular Cell Biology and the Biology Department, University College London, London WC1E 6BT, UK. t.kondo@ucl.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10976069" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Animals, Newborn
;
Astrocytes/chemistry/*cytology
;
Blood
;
Bone Morphogenetic Proteins/pharmacology
;
Cell Culture Techniques
;
*Cell Differentiation
;
Cells, Cultured
;
Culture Media
;
Culture Media, Serum-Free
;
Fibroblast Growth Factor 2/pharmacology
;
Galactosylceramides/analysis
;
Glial Fibrillary Acidic Protein/analysis
;
Glutamate Decarboxylase/biosynthesis/genetics
;
Isoenzymes/biosynthesis/genetics
;
Neurofilament Proteins/analysis/biosynthesis
;
Neurons/chemistry/*cytology
;
Oligodendroglia/chemistry/*cytology
;
Optic Nerve/cytology
;
Platelet-Derived Growth Factor/pharmacology
;
Rats
;
Stem Cells/chemistry/*cytology
;
Thyroid Hormones/pharmacology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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