Publication Date:
2015-01-14
Description:
Article The drug amlexanox is known to improve obesity-related metabolic dysfunction in mice. Here the authors show that this effect is mediated by interleukin-6 secreted from subcutaneous adipocytes, which then inhibits gluconeogenesis in the liver by phosphorylating the hepatic transcription factor Stat3. Nature Communications doi: 10.1038/ncomms7047 Authors: Shannon M. Reilly, Maryam Ahmadian, Brian F. Zamarron, Louise Chang, Maeran Uhm, BreAnne Poirier, Xiaoling Peng, Danielle M. Krause, Evgenia Korytnaya, Adam Neidert, Christopher Liddle, Ruth T. Yu, Carey N. Lumeng, Elif A. Oral, Michael Downes, Ronald M. Evans, Alan R. Saltiel
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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