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  • 1
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    Axonal self-destruction and neurodegeneration (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-05-04
    Description: Neurons seem to have at least two self-destruct programs. Like other cell types, they have an intracellular death program for undergoing apoptosis when they are injured, infected, or not needed. In addition, they apparently have a second, molecularly distinct self-destruct program in their axon. This program is activated when the axon is severed and leads to the rapid degeneration of the isolated part of the cut axon. Do neurons also use this second program to prune their axonal tree during development and to conserve resources in response to chronic insults?〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Raff, Martin C -- Whitmore, Alan V -- Finn, John T -- New York, N.Y. -- Science. 2002 May 3;296(5569):868-71.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉MRC Laboratory for Molecular Cell Biology and Cell Biology Unit and the Biology Department, University College London, London WC1E 6BT, UK. m.raff@ucl.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11988563" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Apoptosis ; Axons/*physiology ; Humans ; Mice ; Mice, Mutant Strains ; Motor Neuron Disease/pathology/physiopathology ; *Nerve Degeneration ; Neurodegenerative Diseases/pathology/*physiopathology ; Peripheral Nervous System Diseases/pathology/physiopathology ; *Wallerian Degeneration/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Lack of replicative senescence in cultured rat oligodendrocyte precursor cells (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-02-07
    Description: Most mammalian somatic cells are thought to have a limited proliferative capacity because they permanently stop dividing after a finite number of divisions in culture, a state termed replicative cell senescence. Here we show that most oligodendrocyte precursor cells purified from postnatal rat optic nerve can proliferate indefinitely in serum-free culture if prevented from differentiating; various cell cycle-inhibitory proteins increase, but the cells do not stop dividing. The cells maintain high telomerase activity and p53- and Rb-dependent cell cycle checkpoint responses, and serum or genotoxic drugs induce them to acquire a senescence-like phenotype. Our findings suggest that some normal rodent precursor cells have an unlimited proliferative capacity if cultured in conditions that avoid both differentiation and the activation of checkpoint responses that arrest the cell cycle.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tang, D G -- Tokumoto, Y M -- Apperly, J A -- Lloyd, A C -- Raff, M C -- New York, N.Y. -- Science. 2001 Feb 2;291(5505):868-71. Epub 2001 Jan 18.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉MRC Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11157165" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Apoptosis ; *Cell Aging ; Cell Culture Techniques ; Cell Cycle ; Cell Differentiation ; *Cell Division ; Cells, Cultured ; Contact Inhibition ; Culture Media, Serum-Free ; Cyclin-Dependent Kinases/antagonists & inhibitors/metabolism ; Cyclins/metabolism ; Mutation ; Nucleic Acid Synthesis Inhibitors ; Oligodendroglia/*cytology/physiology ; Optic Nerve/cytology ; Proteins/metabolism ; Rats ; Retinoblastoma Protein/metabolism ; Stem Cells/*cytology/physiology ; Telomerase ; Tumor Suppressor Protein p14ARF ; Tumor Suppressor Protein p53/metabolism ; ras Proteins/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Glial cell diversification in the rat optic nerve (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1989-03-17
    Description: A central challenge in developmental neurobiology is to understand how an apparently homogeneous population of neuroepithelial cells in the early mammalian embryo gives rise to the great diversity of nerve cells (neurons) and supporting cells (glial cells) in the mature central nervous system. Because the optic nerve is one of the several types of glial cells but no intrinsic neurons, it is an attractive place to investigate how neuroepithelial cells diversify. Studies of developing rat optic nerve cells in culture suggest that both cell-cell interactions and intrinsic cellular programs play important parts in glial cell diversification.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Raff, M C -- New York, N.Y. -- Science. 1989 Mar 17;243(4897):1450-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2648568" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Astrocytes/cytology ; Brain/cytology ; Cell Differentiation ; Cell Movement ; Cells, Cultured ; Epithelial Cells ; Morphogenesis ; Neuroglia/*cytology ; Oligodendroglia/cytology ; Optic Nerve/*cytology ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Changing scientific publishing (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-08-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Raff, Martin C -- Stevens, Charles F -- Roberts, Keith -- Shatz, Carla J -- Newsome, William T -- New York, N.Y. -- Science. 2004 Aug 13;305(5686):945-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15310878" target="_blank"〉PubMed〈/a〉
    Keywords: *Internet ; Peer Review, Research ; *Periodicals as Topic ; *Publishing
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Programmed cell death and the control of cell survival: lessons from the nervous system (1993)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1993-10-29
    Description: During the development of the vertebrate nervous system, up to 50 percent or more of many types of neurons normally die soon after they form synaptic connections with their target cells. This massive cell death is thought to reflect the failure of these neurons to obtain adequate amounts of specific neurotrophic factors that are produced by the target cells and that are required for the neurons to survive. This neurotrophic strategy for the regulation of neuronal numbers may be only one example of a general mechanism that helps to regulate the numbers of many other vertebrate cell types, which also require signals from other cells to survive. These survival signals seem to act by suppressing an intrinsic cell suicide program, the protein components of which are apparently expressed constitutively in most cell types.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Raff, M C -- Barres, B A -- Burne, J F -- Coles, H S -- Ishizaki, Y -- Jacobson, M D -- New York, N.Y. -- Science. 1993 Oct 29;262(5134):695-700.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Developmental Neurobiology Programme, University College London, United Kingdom.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8235590" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Apoptosis/*physiology ; Cell Survival/*physiology ; Humans ; Neurons/*cytology ; Oligodendroglia/*cytology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Cell death genes: Drosophila enters the field (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-04-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Raff, M C -- New York, N.Y. -- Science. 1994 Apr 29;264(5159):668-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Medical Research Council Laboratory for Molecular Cell Biology, University College of London, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8171317" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Apoptosis/*genetics ; Caenorhabditis elegans/cytology/genetics ; Drosophila/cytology/*genetics ; *Genes, Insect
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
    Electronic Resource
    Electronic Resource
    Platelet-Derived Growth Factor in Central Nervous System Gliogenesis (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 633 (1991), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1991.tb15605.x
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    The Macroglial Cells of the Rat Optic Nerve (1989)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Neuroscience 12 (1989), S. 517-534 
    Details
    ISSN: 0147-006X
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.ne.12.030189.002505
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  • 9
    Electronic Resource
    Electronic Resource
    A surface antigenic marker for rat Schwann cells (1977)
    [s.l.] : Nature Publishing Group
    Nature 266 (1977), S. 364-366 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The mouse antiserum was raised against a cell line (33B) derived from an ethylnitrosourea-induced tumour arising in the spinal cord and nerve roots of a Wistar-Furth (W/Fu) rat1. After extensive adsorption with rat liver, spleen and thymus, the original serum defined two surface antigens detected ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/266364a0
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  • 10
    Electronic Resource
    Electronic Resource
    Immunoglobulin Determinants on the Surface of Mouse Lymphoid Cells (1970)
    [s.l.] : Nature Publishing Group
    Nature 225 (1970), S. 553-554 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fluorescein-labelled anti-Ig has commonly been used to demonstrate Ig within the cytoplasm of lymphoid cells6. In all of these studies the tissues have been frozen and/or fixed, and the fluorescence has been largely confined to the cytoplasm; the majority of cells stained have been plasma cells. ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/225553a0
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