Publication Date:
2014-03-15
Description:
The intestinal microbiota and tissue-resident myeloid cells promote immune responses that maintain intestinal homeostasis in the host. However, the cellular cues that translate microbial signals into intestinal homeostasis remain unclear. Here, we show that deficient granulocyte-macrophage colony-stimulating factor (GM-CSF) production altered mononuclear phagocyte effector functions and led to reduced regulatory T cell (T(reg)) numbers and impaired oral tolerance. We observed that RORgammat(+) innate lymphoid cells (ILCs) are the primary source of GM-CSF in the gut and that ILC-driven GM-CSF production was dependent on the ability of macrophages to sense microbial signals and produce interleukin-1beta. Our findings reveal that commensal microbes promote a crosstalk between innate myeloid and lymphoid cells that leads to immune homeostasis in the intestine.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291125/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291125/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mortha, Arthur -- Chudnovskiy, Aleksey -- Hashimoto, Daigo -- Bogunovic, Milena -- Spencer, Sean P -- Belkaid, Yasmine -- Merad, Miriam -- F30 DK094708/DK/NIDDK NIH HHS/ -- R01 CA154947/CA/NCI NIH HHS/ -- R01 CA154947A/CA/NCI NIH HHS/ -- R01 CA173861/CA/NCI NIH HHS/ -- U01 AI095611/AI/NIAID NIH HHS/ -- Intramural NIH HHS/ -- New York, N.Y. -- Science. 2014 Mar 28;343(6178):1249288. doi: 10.1126/science.1249288. Epub 2014 Mar 13.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Oncological Sciences, 1470 Madison Avenue, New York, NY 10029, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24625929" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antigens/immunology
;
Eating
;
Granulocyte-Macrophage Colony-Stimulating Factor/genetics/*metabolism
;
Homeostasis
;
*Immune Tolerance
;
Immunity, Innate
;
Interleukin-1beta/immunology
;
Intestines/*immunology/*microbiology
;
Macrophages/*immunology/*microbiology
;
Mice
;
Mice, Mutant Strains
;
Microbiota/*immunology
;
Mouth/immunology
;
Nuclear Receptor Subfamily 1, Group F, Member 3/metabolism
;
T-Lymphocytes, Regulatory/immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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