Publication Date:
1990-07-27
Description:
Neutrophils and monocytes, but not lymphocytes, adhered strongly to plastic surfaces coated with GMP140, a protein of endothelial cells and platelets. This adhesion of neutrophils was mediated by GMP140 and not by the CD18 integrin complex. By contrast, GMP140 in solution inhibited the CD18-dependent adhesion of tumor necrosis factor-alpha-activated neutrophils to plastic surfaces and resting endothelium, but not of resting neutrophils to tumor necrosis factor-alpha-activated endothelium. Thus, the binding of a soluble form of an adhesion protein selectively inhibited another set of adhesive events. Soluble GMP140 may be important in maintaining the nonadhesiveness of neutrophils in the circulation and may serve to limit inflammatory reactions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gamble, J R -- Skinner, M P -- Berndt, M C -- Vadas, M A -- New York, N.Y. -- Science. 1990 Jul 27;249(4967):414-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Human Immunology, Institute of Medical and Veterinary Science, Adelaide, South Australia.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1696029" target="_blank"〉PubMed〈/a〉
Keywords:
Antibodies/pharmacology
;
Antigens, CD/physiology
;
Antigens, CD18
;
Cell Adhesion/*drug effects
;
Endothelium, Vascular/*physiology
;
Humans
;
Neutrophils/*physiology
;
P-Selectin
;
Plastics
;
Platelet Membrane Glycoproteins/*pharmacology
;
Receptors, Leukocyte-Adhesion/immunology/physiology
;
Tumor Necrosis Factor-alpha/pharmacology
;
Umbilical Veins
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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