ISSN:
1662-0356
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Natural Sciences in General
,
Technology
Notes:
Tissue engineering (TE) aims/seeks to achieve the substitution of organ transplantationby the creation of living, functional tissues. It has been suggested that biocompatible porousmaterials (scaffolds) and a controllable 3D environment are required to aid in the 3D cellorganisation and their development into functional tissue. Our research envisions a TE-approachtowards the repair of large, load bearing defects in long bones. In vitro standardised, systematic,quantitative screening of potential bone scaffolds is required to understand how scaffolds can affectcell behaviour. This screening will avoid a trial-and-error approach and thus limit the number ofanimal experiments. Such a screening should be based on the knowledge of mechanical, physicaland (bio)chemical scaffold properties and their interaction with cell behaviour. In addition, thedesign and production of a clinically relevant scaffold requires control over its mechanicalbehaviour and a new approach for cell seeding in a 3D scaffold, as well as providing nutrition forthe engrafted cells. The objective of this research is to gain substantial knowledge about guidedbone regeneration and to develop quantitative methodologies that can lead to consistent andreproducible bone regeneration
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/42/transtech_doi~10.4028%252Fwww.scientific.net%252FAST.49.181.pdf
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