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  • 1
    Electronic Resource
    Electronic Resource
    Identification of non-proliferating cells in melanoma B16 tumour (1977)
    [s.l.] : Nature Publishing Group
    Nature 270 (1977), S. 607-609 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The experimental details have been published elsewhere4"6. Basically, the B16 melanoma tumour was grown in the foot pad of C57 mice: a suspension of 3 x 105 tumour cells was grafted s.c. into the foot pad of a 3-month-old mouse and 10 d later the tumour was excised. Triplicate smear preparations of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/270607a0
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  • 2
    Electronic Resource
    Electronic Resource
    Radiosensitivity and recovery of mouse L cells during the cell cycle (1977)
    Springer
    Radiation and environmental biophysics 14 (1977), S. 285-294 
    Details
    ISSN: 1432-2099
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Summary Mouse fibroblasts, subline L-929 F were synchronized by mitotic detachment. The synchronized cell cultures were irradiated with 200 kVp X-rays at different time after mitosis, and age reponse functions and dose effect curves were determined using the colony test. The cell age in the mitotic cycle was obtained from a computer analysis of flow cytometric DNA histograms. Both intrinsic radiosensitivity 1/D 0 and extrapolation numbern were found to vary during the cell cycle. TheD 0 has a maximum value of 176 ± 1 rad in the middle ofG 1 phase and a minimum of 71 ± 1 rad at theS/G 2 transition, while the extrapolation number is rather constant from the beginning ofG 1 phase (1.9 ± 0.1) to the middle ofS phase (2.3 ± 0.1) and reaches a steep maximum of 9.3 ± 1.1 atS/G 2 transition. The values ofn in the various phases of cell cycle are compared with the respective values of the recovery factorγ determined after fractionated irradiation. - Cell survival after a single dose of 616 rad has minima for irradiation atG 1/S transition and in earlyG 2 phase; the survival in earlyG 2 being about 40 times smaller than in earlyG 1 phase. Implications for a cell cycle specific therapy are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01325243
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  • 3
    Electronic Resource
    Electronic Resource
    Die dauer der phasen im zellzyklus von l-929-zellen (1973)
    Springer
    Radiation and environmental biophysics 10 (1973), S. 45-50 
    Details
    ISSN: 1432-2099
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Description / Table of Contents: Zusammenfassung Die mittlere Dauer der Phasen des Zellzyklus von L-929-Zellen in Kultur wurde autoradiographisch und impulscytophotometrisch bestimmt. Die Mittelwerte von fünf Untersuchungen wichen biei beden Verfahren nur im Rahmen des statistischen Fehlers voneinander ab. Die Reproduzierbarkeit der ICP-Messungen war besser. Auf Konsequenzen für eine klinische Anwendung wird hingewiesen.
    Notes: Summary The mean duration of the different phases of the mitotic cycle in L-929 cells cultivatedin vitro was determined autoradiographically and also by impulsecytophotometry. The mean values obtained with the two methods each involving 5 experiments were within the frame of statistical error. The reproducibility of the ICP measurements was better. The importance in clinical application is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01189910
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  • 4
    Electronic Resource
    Electronic Resource
    DNA-synthesis in synchronized L-cells after irradiation during the G1-phase of the cell cycle (1975)
    Springer
    Radiation and environmental biophysics 12 (1975), S. 23-30 
    Details
    ISSN: 1432-2099
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Summary Mouse fibroblast L-929 cells synchronized by mitotic selection were irradiated during the G1-phase of the cell cycle with a dose of 1000 rad. The rate of DNA synthesis was measured by3H-thymidine incorporation, and the progression of the cells through the cell cycle was determined using a pulse-cytophotometer. Irradiation caused a decrease in the rate of DNA synthesis to half the control value, and an extension of the S-phase to twice its normal duration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02339806
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  • 5
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    Identification of non-proliferating cells in melanoma B16 tumour (1977)
    Springer Nature
    Details
    Publication Date: 1977-12-01
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Springer Nature
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