ISSN:
1013-9826
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
In this study, novel polycaprolactone/hydroxyapatite (PCL/HA) scaffolds were prepared toincrease mechanical properties and degradation of PCL/HA ones for bone tissue engineering. PCLmacromers were synthesized through the reaction of PCL diol (Mn: 530, 1250, and 2000) and PCL triol (Mn:900) with acryloyl chloride and confirmed using nuclear magnetic resonance spectrometer (NMR) andfourier transform infrared (FTIR). The PCL/HA scaffolds were prepared by cross-linking of PCL macromerin the presence of HA by UV treatment and freeze drying methods. Mechanical property and porosity as wellas degradability of the PCL/HA scaffolds were also investigated. PCL/HA scaffolds showed fasterdegradation and higher compressive modulus than those of PCL itself due to their low crystallinity andmodification of terminal groups. The pore morphology and pore sizes of the PCL/HA scaffold were checkedby scanning electron microscope (SEM). Cell cytotoxicity and proliferation of MG-63 osteoblast culturedonto the PCL/HA scaffold was assessed by lactate dehydrogenase (LDH) assay and Alamar blue assay,respectively. The novel PCL/HA scaffold appears to be suitable for bone substitutes
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/54/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.342-343.265.pdf
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