ISSN:
1573-4919
Keywords:
cyclic ADP-ribose
;
inositol 1,4,5-trisphosphate
;
Ca+2-induced Ca+2 release
;
Ca+2 mobilization
;
ADP-ribosyl cyclase
;
CD38
;
cyclic ADP-ribose hydrolase
;
cyclic ADP-ribose receptor
;
ryanodine receptor
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
Notes:
Abstract Mobilization of Ca+2 from intracellular stores is a signalling mechanism that is of fundamental importance to many cellular processes. It is mediated by two major mechanisms, the inositol 1,4,5-trisphosphate pathway and the Ca+2-induced Ca+2 release process. A naturally occurring metabolite of NAD+ called cyclic ADP-ribose has been discovered recently and shown to be as effective as inositol 1,4,5-trisphosphate in mobilizing Ca+2 stores in sea urchin eggs, a marine invertebrate cell, as well as several mammalian cells. This article reviews the accumulating evidence that indicates cyclic ADP-ribose may function as a physiological regulator of the Ca+2-induced Ca+2 release process and the current knowledge about its receptor as well as the enzymes involved in its metabolism.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00928466
Permalink