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  • 1
    Electronic Resource
    Electronic Resource
    CHEMICAL BASIS OF PARASITISM (1963)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 113 (1963), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1963.tb40675.x
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  • 2
    Electronic Resource
    Electronic Resource
    Serial Passage of Trypanosoma lewisi in the Heterologous Mouse Host. I. Development in Calorically-restricted Hosts. (1959)
    Oxford, UK : Blackwell Publishing Ltd
    The @journal of eukaryotic microbiology 6 (1959), S. 0 
    Details
    ISSN: 1550-7408
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: SYNOPSIS. Two isolates (“A” and “B”) of Trypanosoma lewisi from the same rat stock source were serially transferred in calorically-restricted mice supplemented daily with normal rat serum. The “A” strain was transferred consecutively through 300 mice over a period of more than 3 years and was voluntarily discontinued. The “B” strain died out spontaneously after 43 consecutive passages in mice. The developmental histories of these 2 isolates were analyzed and compared with respect to duration of the parasitemic period, interval to the next subsequent passage in mice, day of death of each host animal, proportion of host animals that died, intensity of parasitemia in mouse tail blood, interval required for development of the observed maximal parasitemia, and duration of maximal parasitemia.“A” appeared to have become progressively adapted to the mouse as judged by a decrease in parasitemic period with successive transfer associated with a progressive increase in trypanosome population, and declines in the interval required for development of the observed maximal parasitemia and in the duration of this maximal response. There did not appear to be any correlation of the percentage of animals that died with any other factor. The “B” strain did not appear to have adapted itself to mice as judged by the foregoing criteria.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1550-7408.1959.tb04374.x
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  • 3
    Electronic Resource
    Electronic Resource
    Trypanosoma duttoni: Oxygen uptake by liver slices of normal and pantothenate-deficient mice (1971)
    Springer
    Parasitology research 36 (1971), S. 346-354 
    Details
    ISSN: 1432-1955
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Endogenously liver slices from mice infected with Trypanosoma duttoni and fed a control diet, consumed an average of 31 μl O2/mg N/hour which was significantly different from that (20 μl) utilized by uninfected mouse liver slices. Average endogenous $$Q_{0_2 }$$ values for liver slices from pantothenate-deficient mice were 25 μl for infected and 20 μl for non-infected mice. Average endogenous $$Q_{0_2 }$$ values for liver slices from control, pair-fed mice were 32 μl for infected and 23 μl for non-infected hosts. With pyruvate as substrate $$Q_{0_2 }$$ values for liver slices from well-fed mice were 25% higher than endogenous rates for infected hosts and 45% for non-infected hosts. For pantothenate-deficient mice, $$Q_{0_2 }$$ values for pyruvate utilization were greater than endogenous rates by 32% for infected animals and 25% greater for non-infected ones. For pair-fed control mice, $$Q_{0_2 }$$ values for pyruvate utilization were greater than endogenous rates by about a quarter for both infected and uninfected mice. Liver slices from infected hosts consistently utilized more oxygen with pyruvate as substrate than uninfected mice (34% for mice on complete diet; 34% for mice on pantothenate-deficient diet; and 41% for mice on pair-fed control diet).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00259641
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  • 4
    Electronic Resource
    Electronic Resource
    Trypanosoma lewisi: Duration of immune state in rats (1972)
    Springer
    Parasitology research 38 (1972), S. 344-350 
    Details
    ISSN: 1432-1955
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Rats infected with Trypanosoma lewisi were studied for more than 500 days to measure the duration of the immune state. Sixty rats arranged in groups of ten were each inoculated with 100 cells of T. lewisi on Day 1. Subsequently, the first group was re-inoculated with the same number of trypanosomes on Day 56. On Day 141 the first group was again challenged and the second group was challenged for the first time. On Day 234 the first group was reexposed for the third time; the second group for the second, and the third group of rats was reexposed for the first time. This pattern was continued at Days 324, 414 and 505 when the 1st group was reexposed for the first time. Additional rats were inoculated on each challenge date for control of viability of the trypanosomes. Techniques for detection of parasites in the host's body were: (a) wet films of tail blood; (b) permanent blood smears; and (c) subinoculation of host blood into susceptible animals (xenodiagnosis). The immune state was steady in all groups during the periods of observation. No active trypanosomes were detected at any period of observation. However, inactive or dead trypanosomes were found in the peripheral blood of rats reinoculated on Day 414 and 505. Control animals showed active parasitemias during each reinoculation period.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00329281
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