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  • 1
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    Functional expression of a new pharmacological subtype of brain nicotinic acetylcholine receptor (1988)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1988-04-15
    Description: A new type of agonist-binding subunit of rat neuronal nicotinic acetylcholine receptors (nAChRs) was identified. Rat genomic DNA and complementary DNA encoding this subunit (alpha 2) were cloned and analyzed. Complementary DNA expression studies in Xenopus oocytes revealed that the injection of messenger RNAs (mRNAs) for alpha 2 and beta 2 (a neuronal nAChR subunit) led to the generation of a functional nAChR. In contrast to the other known neuronal nAChRs, the receptor produced by the injection of alpha 2 and beta 2 mRNAs was resistant to the alpha-neurotoxin Bgt3.1. In situ hybridization histochemistry showed that alpha 2 mRNA was expressed in a small number of regions, in contrast to the wide distribution of the other known agonist-binding subunits (alpha 3 and alpha 4) mRNAs. These results demonstrate that the alpha 2 subunit differs from other known agonist-binding alpha-subunits of nAChRs in its distribution in the brain and in its pharmacology.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wada, K -- Ballivet, M -- Boulter, J -- Connolly, J -- Wada, E -- Deneris, E S -- Swanson, L W -- Heinemann, S -- Patrick, J -- New York, N.Y. -- Science. 1988 Apr 15;240(4850):330-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Salk Institute for Biological Studies, San Diego, CA 92138.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2832952" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Base Sequence ; Brain/*metabolism ; DNA Restriction Enzymes ; Female ; *Genes ; Molecular Sequence Data ; Neurons/metabolism ; Nucleotide Mapping ; Oocytes/metabolism ; Rats ; Receptors, Nicotinic/*genetics/metabolism ; Transcription, Genetic ; Xenopus laevis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Structural evidence for functional domains in the rat hippocampus (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-06-07
    Description: The hippocampus has two major outputs: multisynaptic pathways to the cerebral cortex and a massive descending projection directly to the lateral septal part of the basal ganglia. Here it is shown that the descending output is organized in such a way that different hippocampal regions map in an orderly way onto hypothalamic systems mediating the expression of different classes of goal-oriented behavior. This mapping is characterized by a unidirectional hippocampo-lateral septal projection and then by bidirectional lateral septo-hypothalamic projections, all topographically organized. The connectional evidence predicts that information processing in different regions of the hippocampus selectively influences the expression of different classes of behavior.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Risold, P Y -- Swanson, L W -- New York, N.Y. -- Science. 1996 Jun 7;272(5267):1484-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Program in Neural, Informational, and Behavioral Sciences, University of Southern California, Los Angeles 90089-2520, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8633241" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Autoradiography ; Behavior, Animal ; *Brain Mapping ; Enkephalins/analysis ; Glutamate Decarboxylase/analysis ; Hippocampus/*anatomy & histology/*physiology ; Hypothalamus/anatomy & histology/physiology ; In Situ Hybridization ; Memory/physiology ; Neural Pathways ; Neuropeptides/analysis ; Pyramidal Cells/cytology/physiology ; Rats ; Septal Nuclei/*anatomy & histology/*physiology ; Somatostatin/analysis ; gamma-Aminobutyric Acid/analysis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Central noradrenergic pathways for the integration of hypothalamic neuroendocrine and autonomic responses (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-11-06
    Description: Immunohistochemical and axonal transport methods were used to describe the organization of a series of central noradrenergic pathways that interrelate the nucleus of the solitary tract, which receives primary visceral sensory information, and the paraventricular and supraoptic nuclei of the hypothalamus, which participate in autonomic and neuroendocrine modes of homeostatic control. The results indicate that pathways arising from noradrenergic cells in the dorsal vagal complex, the ventrolateral medulla, and the locus coeruleus end in specific subdivisions of the paraventricular and supraoptic nuclei which are involved in the regulation of responses from the pituitary gland and from both divisions of the autonomic nervous system. This circuitry may play an important role in the integration of hypothalamic responses to visceral stimuli.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sawchenko, P E -- Swanson, L W -- DA-00259/DA/NIDA NIH HHS/ -- NS-06734/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1981 Nov 6;214(4521):685-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7292008" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain Mapping ; Homeostasis ; Hypothalamus/*physiology ; Neural Pathways/physiology ; Neurosecretory Systems/physiology ; Paraventricular Hypothalamic Nucleus/physiology ; Rats ; Supraoptic Nucleus/physiology ; Sympathetic Nervous System/*physiology ; Vagus Nerve/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Expression in brain of a messenger RNA encoding a novel neuropeptide homologous to calcitonin gene-related peptide (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-09-13
    Description: As a consequence of alternative RNA processing events, a single rat gene can generate messenger RNA's (mRNA's) encoding either calcitonin or a neuropeptide referred to as alpha-type calcitonin gene-related peptide (alpha-CGRP). An mRNA product of a related gene has been identified in rat brain and thyroid encoding the protein precursor of a peptide differing from alpha-CGRP by only a single amino acid. The RNA encoding this peptide, which is referred to as beta-CGRP, appears to be the only mature transcript of the beta-CGRP gene. Hybridization histochemistry reveals a similar distribution of alpha- and beta-CGRP mRNA's, but their relative levels of expression vary in different cranial nerve nuclei. Thus beta-CGRP is a new member of a family of related genes with potential functions in regulating the transduction of sensory and motor information.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Amara, S G -- Arriza, J L -- Leff, S E -- Swanson, L W -- Evans, R M -- Rosenfeld, M G -- New York, N.Y. -- Science. 1985 Sep 13;229(4718):1094-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2994212" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; *Brain Chemistry ; Calcitonin Gene-Related Peptide ; DNA/analysis ; DNA Restriction Enzymes/metabolism ; Gene Expression Regulation ; Nerve Tissue Proteins/*genetics ; RNA, Messenger/*analysis ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Neural circuitry: chemical neuroanatomy (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-05-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Swanson, L W -- New York, N.Y. -- Science. 1984 May 18;224(4650):739-40.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17780619" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
    Electronic Resource
    Electronic Resource
    AN OLEFINIC FREE-RADICAL SCAVENGER FOR PHOTOCHEMICAL STUDIES IN AQUEOUS SOLUTIONS: APPLICATION TO THE PHOTOLYSIS OF HYDROGEN PEROXIDE AND ACETONE AT 2537 Å.1 (1959)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 81 (1959), S. 756-757 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja01512a068
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  • 7
    Electronic Resource
    Electronic Resource
    Purification of acetylcholine receptors from the muscle of Electrophorus electricus (1983)
    s.l. : American Chemical Society
    Biochemistry 22 (1983), S. 3796-3800 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00285a013
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  • 8
    Electronic Resource
    Electronic Resource
    High-field ion sources : International conference on ion sources (1990)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 61 (1990), S. 363-365 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: High electric fields may be used to create ions either by field evaporation, as in the case of liquid metal ion sources (LMISs) or by field ionization, as in the case of gas-phase field ionization sources (GFISs). LMISs have now reached a mature state of development and have found an increasing number of focused beam applications, ranging from submicron mask repair to maskless ion implantation. They may be fabricated from either pure elements, or from alloys, provided that the element or alloy vapor pressure is low enough to avoid excessive evaporation. In the case of alloys, it is necessary to employ a mass filter, typically a Wien filter, to remove unwanted ion species from the ion beam. Angular intensities, at the threshold of source operation, range from 1 μA/cm2 for alloy LMIS ion species to 20 μA/cm2 for elemental LMISs; under the same operating conditions, the ion energy spreads are ∼5 eV. Recent advances in the development of GFISs raise the possibility that GFISs may be nearing the stage when they also might be used in fine focus applications. By special shaping of the metal emitter in the apex region and by cooling the emitter to ∼20 K; it has been found possible to cause confinement of the ion emission to ∼0.5° half-angle, thereby increasing angular intensities of beams of He+ or H+2 to values similar to those obtained from LMISs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1141294
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  • 9
    Electronic Resource
    Electronic Resource
    Influence of surface segregation on wetting of liquid metal alloys (1988)
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 92 (1988), S. 3925-3934 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/j100324a047
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  • 10
    Electronic Resource
    Electronic Resource
    A Family of Pou-Domain and Pit-1 Tissue-Specific Transcription Factors in Pituitary and Neuroendocrine Development (1990)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 52 (1990), S. 773-791 
    Details
    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.ph.52.030190.004013
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