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  • 1
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    Physical Absorption Of CO2 in Protic and Aprotic Ionic Liquids: An Interaction Perspective (2015)
    American Chemical Society (ACS)
    Details
    Publication Date: 2015-08-21
    Description: The Journal of Physical Chemistry B DOI: 10.1021/acs.jpcb.5b05115
    Electronic ISSN: 1520-5207
    Topics: Chemistry and Pharmacology , Physics
    Published by American Chemical Society (ACS)
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  • 2
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    Deep-Water Sediment Bypass (2015)
    Society for Sedimentary Geology (SEPM)
    Details
    Publication Date: 2015-09-26
    Description: :  Submarine gravity flows are a key process for transporting large volumes of sediment from the continents to the deep sea. The location, volume, and character of the sediment bypassed by these flows dictates the areal extent and thickness of the associated deposits. Despite its importance, sediment bypass is poorly understood in terms of flow processes and the associated stratigraphic expression. We first examine the relationships between the physical parameters that govern bypass in flows, before assessing the variable stratigraphic expression of bypass from modern seafloor, outcrop, and subsurface datasets. Theoretical and numerical approaches distinguish grain size, slope, flow size, and sediment concentration as parameters that exert major controls on flow bypass. From field data, a suite of criteria are established to recognize bypass in the geological record. We identify four bypass-dominated zones, each of which is associated with a set of diagnostic criteria: slope-channel bypass, slope-bypass from mass wasting events, base-of-slope bypass, and basin-floor bypass. As the expression of bypass varies spatially and is dependent on the scale of observation, a range of scale-dependent criteria are required for robust interpretation of these zones in the field or subsurface. This synthesis of deep-water sediment bypass highlights the challenge in quantitatively linking process with product. The establishment of criteria to recognize sediment bypass, qualitatively linked with flow processes, is an important step towards improving our understanding of submarine flow dynamics and resultant stratigraphic architecture.
    Print ISSN: 1527-1404
    Topics: Geosciences
    Published by Society for Sedimentary Geology (SEPM)
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  • 3
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    Spatial and Temporal Evolution of a Permian Submarine Slope Channel-Levee System, Karoo Basin, South Africa (2011)
    Society for Sedimentary Geology (SEPM)
    Details
    Publication Date: 2011-08-01
    Description: The Laingsburg depocenter of the SW Karoo Basin, South Africa, includes a series of sandstone-dominated deepwater clastic deposits (units A and B of the Laingsburg Formation and Unit C to Unit G of the overlying Fort Brown Formation) separated vertically by regional mudstones and records basin-floor to upper-slope deposition during the Permian icehouse climate. Unit C provides nearly continuous exposures over tens of kilometers, and the presence of regionally persistent internal mudstone markers (lower and upper C mudstones) allows the distribution of sedimentary facies and architectural elements of a slope-turbidite system to be documented for more than 30 km downslope and 20 km across slope. The spatial and temporal distribution of architectural elements and interpreted depositional environments (external levees, channel belts confined by a combination of basal erosion and overbank aggradation along the margins, and distributive frontal splays) reveals distinct changes in the sedimentation pattern and stratal architecture of the turbidite system through time. Unit C evolved in a stepwise manner from a weakly incised, levee-confined channel belt and its downdip distributive frontal splays (C1), through a more entrenched and sinuous channel-levee complex set that fed submarine fans farther into the basin (C2), to a regionally backstepping package of thin-bedded deposits of a distal distributive system (C3). Unit C is interpreted as a lowstand sequence set, composed of three depositional sequences, each of which includes a sandstone-dominated lowstand systems tract (C1, C2, and C3) and a mudstone-prone interval that is taken to represent the transgressive and highstand systems tracts. The overlying combined transgressive and highstand sequence set is marked by the 30-m-thick C-D mudstone interposed between Unit C and Unit D. Unit C and the C-D mudstone together form the Unit C composite sequence. At the scale of the Unit C lowstand sequence set, the evolutionary trend from C1 to C3 reflects an overall basinward then landward stepping of the system across the depositional profile, which is interpreted as the product of an overall waxing then waning of flow energy (volume and efficiency).
    Print ISSN: 1527-1404
    Topics: Geosciences
    Published by Society for Sedimentary Geology (SEPM)
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  • 4
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    Anion–Anion Interactions in the Crystal Packing of Functionalized Methanide Anions: An Experimental and Computational Study (2014)
    American Chemical Society (ACS)
    Details
    Publication Date: 2014-03-20
    Description: Crystal Growth & Design DOI: 10.1021/cg500051m
    Print ISSN: 1528-7483
    Electronic ISSN: 1528-7505
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Published by American Chemical Society (ACS)
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  • 5
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    Coordination of Rho GTPase activities during cell protrusion (2009)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2009-08-21
    Description: The GTPases Rac1, RhoA and Cdc42 act together to control cytoskeleton dynamics. Recent biosensor studies have shown that all three GTPases are activated at the front of migrating cells, and biochemical evidence suggests that they may regulate one another: Cdc42 can activate Rac1 (ref. 8), and Rac1 and RhoA are mutually inhibitory. However, their spatiotemporal coordination, at the seconds and single-micrometre dimensions typical of individual protrusion events, remains unknown. Here we examine GTPase coordination in mouse embryonic fibroblasts both through simultaneous visualization of two GTPase biosensors and using a 'computational multiplexing' approach capable of defining the relationships between multiple protein activities visualized in separate experiments. We found that RhoA is activated at the cell edge synchronous with edge advancement, whereas Cdc42 and Rac1 are activated 2 micro-m behind the edge with a delay of 40 s. This indicates that Rac1 and RhoA operate antagonistically through spatial separation and precise timing, and that RhoA has a role in the initial events of protrusion, whereas Rac1 and Cdc42 activate pathways implicated in reinforcement and stabilization of newly expanded protrusions.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885353/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885353/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Machacek, Matthias -- Hodgson, Louis -- Welch, Christopher -- Elliott, Hunter -- Pertz, Olivier -- Nalbant, Perihan -- Abell, Amy -- Johnson, Gary L -- Hahn, Klaus M -- Danuser, Gaudenz -- F30HL094020/HL/NHLBI NIH HHS/ -- R01 DK037871/DK/NIDDK NIH HHS/ -- R01 GM030324/GM/NIGMS NIH HHS/ -- R01 GM057464/GM/NIGMS NIH HHS/ -- R01 GM057464-09/GM/NIGMS NIH HHS/ -- R01 GM071868/GM/NIGMS NIH HHS/ -- R01 GM071868-04/GM/NIGMS NIH HHS/ -- R01 GM57464/GM/NIGMS NIH HHS/ -- R01 GM71868/GM/NIGMS NIH HHS/ -- T32 GM008719/GM/NIGMS NIH HHS/ -- U54 GM064346/GM/NIGMS NIH HHS/ -- U54 GM064346-099029/GM/NIGMS NIH HHS/ -- England -- Nature. 2009 Sep 3;461(7260):99-103. doi: 10.1038/nature08242. Epub 2009 Aug 19.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Biology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19693013" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biosensing Techniques ; Cell Movement ; Cell Shape ; Cell Surface Extensions/*metabolism ; Embryo, Mammalian/cytology ; Enzyme Activation ; Fibroblasts/cytology/enzymology ; Mice ; Neuropeptides/metabolism ; Protein Transport ; Time Factors ; cdc42 GTP-Binding Protein/metabolism ; rac GTP-Binding Proteins/metabolism ; rac1 GTP-Binding Protein ; rho GTP-Binding Proteins/*metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 6
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    Activation of endogenous Cdc42 visualized in living cells (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-09-14
    Description: Signaling proteins are tightly regulated spatially and temporally to perform multiple functions. For Cdc42 and other guanosine triphosphatases, the subcellular location of activation is a critical determinant of cell behavior. However, current approaches are limited in their ability to examine the dynamics of Cdc42 activity in living cells. We report the development of a biosensor capable of visualizing the changing activation of endogenous, unlabeled Cdc42 in living cells. With the use of a dye that reports protein interactions, the biosensor revealed localized activation in the trans-Golgi apparatus, microtubule-dependent Cdc42 activation at the cell periphery, and activation kinetics precisely coordinated with cell extension and retraction.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nalbant, Perihan -- Hodgson, Louis -- Kraynov, Vadim -- Toutchkine, Alexei -- Hahn, Klaus M -- GM57464/GM/NIGMS NIH HHS/ -- GM64346/GM/NIGMS NIH HHS/ -- R01 GM057464/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2004 Sep 10;305(5690):1615-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7365, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15361624" target="_blank"〉PubMed〈/a〉
    Keywords: Actins/metabolism ; Algorithms ; Animals ; *Biosensing Techniques ; Cell Adhesion ; Cell Line ; Cell Membrane/*metabolism ; Cell Polarity ; Cell Surface Extensions/metabolism/ultrastructure ; Endothelial Cells/metabolism/ultrastructure ; Fibroblasts ; Fluorescence ; Fluorescent Dyes/chemistry/metabolism ; Green Fluorescent Proteins ; Humans ; Luminescent Proteins ; Mice ; Microtubules/metabolism ; Neutrophil Activation ; Neutrophils/*metabolism ; Proteins/chemistry/metabolism ; Pseudopodia/metabolism ; Pyrimidinones/metabolism ; Sensitivity and Specificity ; Wiskott-Aldrich Syndrome Protein ; cdc42 GTP-Binding Protein/*metabolism ; rho GTP-Binding Proteins/metabolism ; trans-Golgi Network/*metabolism/ultrastructure
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    The Role of Acoustics in the Perceived Suitability of, and Well-Being in, Informal Learning Spaces (2016)
    Sage
    Details
    Publication Date: 2016-05-20
    Description: Post-secondary institutions require appropriately designed informal learning spaces (ILSs) outside of classrooms for studying and group-work activities, but few studies have investigated how these spaces perform, especially in terms of acoustics. We measured objective acoustical characteristics and architectural features in 23 such spaces, and captured environmental assessments and well-being outcomes from a survey of 850 student occupants. Objective measures indicated that sound levels generated by occupants and other sound sources tended to exceed maximum values recommended by standards. Some components of perceived suitability and well-being were greater in spaces with lower background sound levels (e.g., from ventilation systems), but with more occupant-generated sound, and more reverberation. Furthermore, some design features such as more vegetation, the presence of soft furnishings, and lower seating density predicted some components of perceived suitability and well-being. This evaluation of ILSs offers lessons for designers and suggests additional directions for further study.
    Print ISSN: 0013-9165
    Electronic ISSN: 1552-390X
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Psychology
    Published by Sage
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  • 8
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    Interaction of crustal heterogeneity and lithospheric processes in determining passive margin architecture on the southern Namibian margin (2016)
    Geological Society (of London)
    Details
    Publication Date: 2016-03-18
    Description: The influence of pre-rift crustal heterogeneity and structure on the evolution of a continental rift and its subsequent passive margin is explored. The absence of thick Aptian salts in the Namibian South Atlantic allows imaging of sufficient resolution to distinguish different pre-rift basement seismic facies. Aspects of the pre-rift basement geometry were characterized and compared with the geometries of the Cretaceous rift basin structure and with subsequent post-rift margin architectural elements. Half-graben depocentres migrated westwards within the continental synrift phase at the same time as basin-bounding faults became established as hard-linked arrays with lengths of c. 100 km. The rift–drift transition phase, marked by seaward-dipping reflectors, gave way to the early post-rift progradation of clastic sediments off the Namibian coast. In the Late Cretaceous, these shelf clastic sediments were much thicker in the south, reflecting the dominance of the newly formed Orange River catchment as the main entry point for sediments on the South African–Namibian margin. Tertiary clastic sediments largely bypassed the pre-existing shelf area, revealing a marked basinwards shift in sedimentation. The thickness of post-rift megasequences does not vary simply according to the location of synrift half-graben and thinned continental crust. Instead, the Namibian margin exemplifies a margin influenced by a complex interplay of crustal thinning, pre-rift basement heterogeneity, volcanic bodies and transient dynamic uplift events on the evolution of lithospheric strain and depositional architecture.
    Print ISSN: 0305-8719
    Electronic ISSN: 2041-4927
    Topics: Geosciences
    Published by Geological Society (of London)
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  • 9
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    ESCRT-III controls nuclear envelope reformation (2015)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2015-06-05
    Description: During telophase, the nuclear envelope (NE) reforms around daughter nuclei to ensure proper segregation of nuclear and cytoplasmic contents. NE reformation requires the coating of chromatin by membrane derived from the endoplasmic reticulum, and a subsequent annular fusion step to ensure that the formed envelope is sealed. How annular fusion is accomplished is unknown, but it is thought to involve the p97 AAA-ATPase complex and bears a topological equivalence to the membrane fusion event that occurs during the abscission phase of cytokinesis. Here we show that the endosomal sorting complex required for transport-III (ESCRT-III) machinery localizes to sites of annular fusion in the forming NE in human cells, and is necessary for proper post-mitotic nucleo-cytoplasmic compartmentalization. The ESCRT-III component charged multivesicular body protein 2A (CHMP2A) is directed to the forming NE through binding to CHMP4B, and provides an activity essential for NE reformation. Localization also requires the p97 complex member ubiquitin fusion and degradation 1 (UFD1). Our results describe a novel role for the ESCRT machinery in cell division and demonstrate a conservation of the machineries involved in topologically equivalent mitotic membrane remodelling events.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471131/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471131/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Olmos, Yolanda -- Hodgson, Lorna -- Mantell, Judith -- Verkade, Paul -- Carlton, Jeremy G -- 093603/Wellcome Trust/United Kingdom -- Wellcome Trust/United Kingdom -- England -- Nature. 2015 Jun 11;522(7555):236-9. doi: 10.1038/nature14503. Epub 2015 Jun 3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Cancer Studies, Section of Cell Biology and Imaging, King's College London, London SE1 1UL, UK. ; School of Biochemistry, University of Bristol, Medical Sciences Building, University Walk, Bristol BS8 1TD, UK. ; 1] School of Biochemistry, University of Bristol, Medical Sciences Building, University Walk, Bristol BS8 1TD, UK [2] Wolfson Bioimaging Facility, University of Bristol, Medical Sciences Building, University Walk, Bristol BS8 1TD, UK. ; 1] School of Biochemistry, University of Bristol, Medical Sciences Building, University Walk, Bristol BS8 1TD, UK [2] Wolfson Bioimaging Facility, University of Bristol, Medical Sciences Building, University Walk, Bristol BS8 1TD, UK [3] School of Physiology &Pharmacology, University of Bristol, Medical Sciences Building, University Walk, Bristol BS8 1TD, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26040713" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Line ; Chromatin/metabolism ; Endosomal Sorting Complexes Required for Transport/deficiency/*metabolism ; Humans ; Membrane Fusion ; Mitosis ; Nuclear Envelope/*metabolism ; Protein Transport ; Proteins/metabolism ; Telophase
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 10
    Electronic Resource
    Electronic Resource
    Effect of surface temperature on collision-induced dissociation of 1,1,1,2,3,3,3-heptafluoro-2-nitrosopropene scattered from magnesium oxide (100), gallium arsenide (100), and silver (111) (1991)
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 95 (1991), S. 8387-8393 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/j100174a064
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