ISSN:
0732-0582
Source:
Annual Reviews Electronic Back Volume Collection 1932-2001ff
Topics:
Biology
,
Medicine
Notes:
Abstract The transcription factor NF-kappaB, more than a decade after its discovery, remains an exciting and active area of study. The involvement of NF-kappaB in the expression of numerous cytokines and adhesion molecules has supported its role as an evolutionarily conserved coordinating element in the organism's response to situations of infection, stress, and injury. Recently, significant advances have been made in elucidating the details of the pathways through which signals are transmitted to the NF-kappaB:IkappaB complex in the cytosol. The field now awaits the discovery and characterization of the kinase responsible for the inducible phosphorylation of IkappaB proteins. Another exciting development has been the demonstration that in certain situations NF-kappaB acts as an anti-apoptotic protein; therefore, elucidation of the mechanism by which NF-kappaB protects against cell death is an important goal. Finally, the generation of knockouts of members of the NF-kappaB/IkappaB family has allowed the study of the roles of these proteins in normal development and physiology. In this review, we discuss some of these recent findings and their implications for the study of NF-kappaB.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1146/annurev.immunol.16.1.225
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