ISSN:
1013-9826
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
In this study, we prepared using low molecular weight water-soluble chitosan nanoparticle loadedpaclitaxel (LMWSC-NPT) and investigated the potential as a drug carrier which is able to accumulate in thetumor site. In the experiment of receptor-mediated endocytosis, LMWSC-NPT was treated with sodium azid(NaN3) as an inhibitor of endocytosis process. As results, the antitumor activity of LMWSC-NPT treatedwith sodium azid didn’t show but LMWSC-NPT was shown the high antitumor activity. Therefore,LMWSC-NPs modified with hydrophobic group will be useful anticancer agent carrier via receptor-mediatedendocytosis
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/54/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.342-343.469.pdf
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