ISSN:
1013-9826
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
In theory, Ultraviolet (UV)-generated free radicals can expedite Acellular dermal matrix(ADM) crosslinking with glucose via the formation of reactive, linear glucose molecules. The aimof this study is to maintain strength and stability of UV-irradiated ADM without the introduction ofcytotoxic chemical crosslinkers. The strength and stability changes of ADM by UV-irradiated withglucose (GLUC) were investigated under various conditions. ADM strength and stability weredetermined by tensile testing, differential scanning calorimetry (DSC), and swelling ratio. Afterexposure to UV-irradiation, ADM containing glucose revealed different mechanical propertiescompare to ADM without glucose, greater resistance to enzymatic degradation, and higher heatdenaturedbreaking loads. DSC explained that glucose-incorporated ADM sterilized by UVirradiationdecreased peak width (Tpeak-Ts) compared to one another. On the other hand, Area (J/g)and Ts increased glucose-incorporated ADM. The exposure of ADM to UV caused significantincrease in hydration, but a significant decrease in the swelling ratio compared with the nonirradiatedADM. These data strongly suggests that free radical-dependent, glucose-derivedcrosslinks provide enhanced strength and enzyme resistance in glucose-incorporated, UV-exposedADM
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/54/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.342-343.337.pdf
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