ISSN:
1013-9826
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
This study is to develop a novel method for preparation of the chitosan scaffold havinginterconnected open pore structure and controlled pore distribution. For this, the effects of additionof non-solvent on chitosan solution were estimated. The porous scaffolds were typically preparedby solid-liquid separation and subsequent sublimation of solvent. Alcohol was used as non-solventfor chitosan. The difference of freezing temperature of each of the components induced the liquidliquidand the liquid-solid phase separation via demixing solution (solvent/non-solvent/chitosan).The morphology, heterogeneous pore distribution and mechanical properties of the scaffolds wereexamined. The addition of non-solvent in chitosan solution was to make the controlledhomogeneous micropores and improved interconnectivity between pores without any surface skinlayer. For control chitosan scaffold, the pore size was mainly about 80~100 μm. On the contrary,Pore diameters could be controlled mainly within the range 30~100 μm, with a variation ofsolvent/non-solvent ratio. The number of minute pore (4~25 μm) over chitosan scaffold increasedwith increasing ratio of non-solvent. New prepared scaffold exhibited larger value of breakingelongation, more elasticity, but less tensile strength than that of control scaffold
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/54/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.342-343.65.pdf
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