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  • 1
    Electronic Resource
    Electronic Resource
    Aufnahme von thymidin durch mastocytomzellenin vitro unter der einwirkung von podophyllumstoffen (1964)
    Springer
    Cellular and molecular life sciences 20 (1964), S. 524-525 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary SP-G and SP-I, two podophyllum preparations with spindle poison activity, were tested for their effect on3H-thymidine incorporation into P-815 mastocytoma cellsin vitro. Concentrations which inhibited cell multiplication completely did not affect DNA-synthesis as measured by thymidine incorporation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02154093
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  • 2
    Electronic Resource
    Electronic Resource
    Mikrohistoautoradiographische Untersuchungen über die Verteilung von tritiummarkierten Phenothiazinen im Auge (1966)
    Springer
    Cellular and molecular life sciences 22 (1966), S. 153-155 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Microhistoautoradiographic and radiometric investigations show that phenothiazines electively accumulate in the melanin-bearing structures of the eye, especially in the chorioid. Retinotoxicity is not only the effect of an accumulation of melanin, but also the consequence of the specific substance-toxicity and the biological importance of the chorio-capillaris which varies between the different species.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01897703
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  • 3
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of unlabelled and14C-labelled pindolol in uraemia (1974)
    Springer
    European journal of clinical pharmacology 7 (1974), S. 25-29 
    Details
    ISSN: 1432-1041
    Keywords: Pindolol ; uraemia ; pharmacokinetics ; β-blockade
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The elimination of pindolol in 25 patients with various degrees of renal failure has been studied after an intravenous dose of 3 mg. A linear correlation was not found between the elimination rate of pindolol and the endogenous creatinine clearance, and the half-life of the unchanged drug was independent of the severity of the renal failure. This implies greater metabolism of pindolol in anuric patients and the extrarenal elimination rate constantk mwas increased. Three patients with severe renal failure were given 3 mg14C-pindolol. They showed almost constant plasma levels of radio-activity for 6 h and then slow excretion with a half-life of 48 h, because of accumulation of metabolites in the blood. Up to 90% of the metabolites are glucuronides and sulphates which have no beta-blocking or other clinical activity. Thus, to produce beta-adrenergic blockade the same dose of indolol is required in healthy patients as in those with uraemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00614386
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  • 4
    Electronic Resource
    Electronic Resource
    Bioavailability studies with Digoxin-Sandoz® and Lanoxin® (1975)
    Springer
    European journal of clinical pharmacology 8 (1975), S. 371-376 
    Details
    ISSN: 1432-1041
    Keywords: Digoxin ; bioavailability ; plasma levels ; cumulative urinary excretion ; particle size ; man
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Various brands of digoxin tablets, and even different batches of one brand, may differ greatly in bioavailability. Digoxin-Sandoz® tablets have been compared with Lanoxin® manufactured between 1969 and 1972 and after May 1972. Comparisons were also made between and within batches of Digoxin-Sandoz tablets. Three separate cross-over studies were conducted involving a total of 20 volunteers. Digoxin-Sandoz tablets were shown to have a constant bioavailability and to produce plasma concentrations very similar to “new” Lanoxin. Storage for 2 years of one batch of Digoxin-Sandoz did not alter the bioavailability. Particle size was shown to influence bioavailability. Care should be exercised when plasma data alone are interpreted as an index of bioavailability. Measures of bioavailability based on plasma data obtained up to 6 h after administration differed from those based on cumulative urinary excretion data (in this study by a factor of about 2), which can lead to the belief that a difference in bioavailability is much greater than is actually the case. Data from cumulative urinary excretion, collected over a sufficiently long period of time, are likely to be the most reliable method for determining the bioavailability of a substance such as digoxin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00562665
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  • 5
    Electronic Resource
    Electronic Resource
    Eine Schnellmethode zur Bestimmung von Tritium, Radiokohlenstoff und Radioschwefel in beliebigem organischem Probenmaterial mittels des Flüssigkeits-Scintillations-Zählers (1961)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 44 (1961), S. 1956-1966 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A detailed description is given of the determination of 3H, 14C and 35S in any material by the oxygen flask method followed by liquid scintillation counting. Improved apparatus and simplified sample preparation enable the analyses to be carried out quickly. For all determinations of 14C and 35S only one absorption solution is used. The use of an internal standard is no longer necessary, as the counting efficiency for all samples of the same isotope is constant under standard conditions. The accuracy and reproducibility are at least as good as those for other analysis methods. Safety measures are indicated.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19610440718
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  • 6
    Electronic Resource
    Electronic Resource
    Synthese von Tritium-markierten Phenothiazinen (1963)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 46 (1963), S. 586-591 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A general method for labeling phenothiazines at specific positions in the ring with tritium is described. Specific activities of several hundreds of mC/mM are attainable.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19630460218
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  • 7
    Electronic Resource
    Electronic Resource
    Die Reversibilität der para-Claisen-Umlagerung. Zur Kenntnis der Claisen-Umlagerung VI (1956)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 39 (1956), S. 555-563 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Es wurde gezeigt, dass sich 2, 6-Dimethyl-4-allyl-[γ-14C]-phenylallylather beim Erhitzen auf 168° in ein mit dem Ausgangsmaterial chemisch identisches Produkt umlagert, in welchem die Radioaktivität zu gleichen Teilen in den γ-C-Atomen des O- und C-Allylrestes lokalisiert ist.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19560390228
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  • 8
    Electronic Resource
    Electronic Resource
    Diensynthesen mit 2,4,6-trisubstituierten Phenylallyläthern. Zur Kenntnis der Claisem-Umlagerung IX (1957)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 40 (1957), S. 779-786 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: 1. Es wird gezeigt, dass die bei der reversiblen Claisen-Umlagerung von 2,4,6-trisubstituierten Phenylallyläthern auftretenden Cyclohexadien-(3,5)-on-(1)-Zwischenprodukte sich in guter Ausbeute durch Diensynthese mit Maleinsäureanhydrid oder Acetylendicarbonsäure-dimethylester abfangen lassen, wodurch direkte Diensynthesen mit diesen Arylallyläthern als potentiellen Dienen möglich sind.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19570400330
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  • 9
    Electronic Resource
    Electronic Resource
    Die Spaltung von 2,4,6-Trimethylphenyl-[γ-14C]-allyläther (1958)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 41 (1958), S. 1198-1201 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Die Spaltung von 2,4,6-Trimethylphenyl-[γ-14C]-allyläther mit Bromwasserstoffsäure in Eisessig bei 85-90° liefert [γ-14C-Allylbromid und dieses mit 2,4-Dinitrothiophenol und alkoholischer Lauge 2,4-Dinitrophenyl-][γ-14C-]allylsulfid. Beide Umsetzungen verlaufen daher ohne Umlagerung.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19580410505
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  • 10
    Electronic Resource
    Electronic Resource
    Zur Kinetik der Claisen-Umlagerung. Zur Kenntnis der Claisen-Umlagerung VIII (1957)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 40 (1957), S. 13-26 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Es wurde die thermische Umlagerung des radioaktiven (2,6-Di-methyl-4-allylphenyl)-allyläthers und des 2,4-Dimethylphenyl-allyläthers kinetisch analysiert und die daraus ermittelten Reaktionsgrössen mit denjenigen anderer Claisen-Umlagerungen verglichen.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19570400103
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