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    ERF115 controls root quiescent center cell division and stem cell replenishment (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-10-26
    Description: The quiescent center (QC) plays an essential role during root development by creating a microenvironment that preserves the stem cell fate of its surrounding cells. Despite being surrounded by highly mitotic active cells, QC cells self-renew at a low proliferation rate. Here, we identified the ERF115 transcription factor as a rate-limiting factor of QC cell division, acting as a transcriptional activator of the phytosulfokine PSK5 peptide hormone. ERF115 marks QC cell division but is restrained through proteolysis by the APC/C(CCS52A2) ubiquitin ligase, whereas QC proliferation is driven by brassinosteroid-dependent ERF115 expression. Together, these two antagonistic mechanisms delimit ERF115 activity, which is called upon when surrounding stem cells are damaged, revealing a cell cycle regulatory mechanism accounting for stem cell niche longevity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Heyman, Jefri -- Cools, Toon -- Vandenbussche, Filip -- Heyndrickx, Ken S -- Van Leene, Jelle -- Vercauteren, Ilse -- Vanderauwera, Sandy -- Vandepoele, Klaas -- De Jaeger, Geert -- Van Der Straeten, Dominique -- De Veylder, Lieven -- New York, N.Y. -- Science. 2013 Nov 15;342(6160):860-3. doi: 10.1126/science.1240667. Epub 2013 Oct 24.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Plant Systems Biology, VIB, B-9052 Gent, Belgium.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24158907" target="_blank"〉PubMed〈/a〉
    Keywords: Anaphase-Promoting Complex-Cyclosome/metabolism ; Arabidopsis/*cytology/*growth & development ; Arabidopsis Proteins/genetics/*metabolism ; Cell Cycle/genetics/physiology ; Cell Cycle Proteins/metabolism ; Cell Division/genetics/*physiology ; Mitosis/genetics/physiology ; Peptide Hormones/genetics/metabolism ; Plant Roots/*cytology/*growth & development ; Proteolysis ; Signal Transduction ; Stem Cell Niche ; Stem Cells/*physiology ; Transcription Factors/genetics/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    A DNA-binding-site landscape and regulatory network analysis for NAC transcription factors in Arabidopsis thaliana (2014)
    Oxford University Press
    Details
    Publication Date: 2014-07-04
    Description: Target gene identification for transcription factors is a prerequisite for the systems wide understanding of organismal behaviour. NAM-ATAF1/2-CUC2 (NAC) transcription factors are amongst the largest transcription factor families in plants, yet limited data exist from unbiased approaches to resolve the DNA-binding preferences of individual members. Here, we present a TF-target gene identification workflow based on the integration of novel protein binding microarray data with gene expression and multi-species promoter sequence conservation to identify the DNA-binding specificities and the gene regulatory networks of 12 NAC transcription factors. Our data offer specific single-base resolution fingerprints for most TFs studied and indicate that NAC DNA-binding specificities might be predicted from their DNA-binding domain's sequence. The developed methodology, including the application of complementary functional genomics filters, makes it possible to translate, for each TF, protein binding microarray data into a set of high-quality target genes. With this approach, we confirm NAC target genes reported from independent in vivo analyses. We emphasize that candidate target gene sets together with the workflow associated with functional modules offer a strong resource to unravel the regulatory potential of NAC genes and that this workflow could be used to study other families of transcription factors.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Published by Oxford University Press
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