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  • 1
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    Tumor necrosis factor-alpha activates the sphingomyelin signal transduction pathway in a cell-free system (1992)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1992-03-27
    Description: The mechanism of tumor necrosis factor (TNF)-alpha signaling is unknown. TNF-alpha signaling may involve sphingomyelin hydrolysis to ceramide by a sphingomyelinase and stimulation of a ceramide-activated protein kinase. In a cell-free system, TNF-alpha induced a rapid reduction in membrane sphingomyelin content and a quantitative elevation in ceramide concentrations. Ceramide-activated protein kinase activity also increased. Kinase activation was mimicked by addition of sphingomyelinase but not by phospholipases A2, C, or D. Reconstitution of this cascade in a cell-free system demonstrates tight coupling to the receptor, suggesting this is a signal transduction pathway for TNF-alpha.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dressler, K A -- Mathias, S -- Kolesnick, R N -- 1 F32 GM14207-01/GM/NIGMS NIH HHS/ -- R0-1-CA-42385/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1992 Mar 27;255(5052):1715-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1313189" target="_blank"〉PubMed〈/a〉
    Keywords: Cell-Free System ; Ceramides/*physiology ; Enzyme Activation ; Humans ; In Vitro Techniques ; Phosphorylation ; Protein Kinases/*metabolism ; Receptor, Epidermal Growth Factor/metabolism ; Receptors, Cell Surface/*physiology ; Receptors, Tumor Necrosis Factor ; Second Messenger Systems ; Signal Transduction/*drug effects ; Sphingomyelin Phosphodiesterase/*physiology ; Sphingomyelins/*physiology ; Tumor Cells, Cultured ; Tumor Necrosis Factor-alpha/*pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha. (1991)
    National Academy of Sciences
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    Publication Date: 1991-11-15
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 3
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    Evaluation of gridded snow water equivalent and satellite snow cover products for mountain basins in a hydrologic model (2006)
    Wiley
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    Publication Date: 2006-01-01
    Description: The USGS precipitation-runoff modelling system (PRMS) hydrologic model was used to evaluate experimental, gridded, 1 km2 snow-covered area (SCA) and snow water equivalent (SWE) products for two headwater basins within the Rio Grande (i.e. upper Rio Grande River basin) and Salt River (i.e. Black River basin) drainages in the southwestern USA. The SCA product was the fraction of each 1 km2 pixel covered by snow and was derived from NOAA advanced very high-resolution radiometer imagery. The SWE product was developed by multiplying the SCA product by SWE estimates interpolated from National Resources Conservation Service snow telemetry point measurements for a 6 year period (1995-2000). Measured SCA and SWE estimates were consistently lower than values estimated from temperature and precipitation within PRMS. The greatest differences occurred in the relatively complex terrain of the Rio Grande basin, as opposed to the relatively homogeneous terrain of the Black River basin, where differences were small. Differences between modelled and measured snow were different for the accumulation period versus the ablation period and had an elevational trend. Assimilating the measured snowfields into a version of PRMS calibrated to achieve water balance without assimilation led to reduced performance in estimating streamflow for the Rio Grande and increased performance in estimating streamflow for the Black River basin. Correcting the measured SCA and SWE for canopy effects improved simulations by adding snow mostly in the mid-to-high elevations, where satellite estimates of SCA are lower than model estimates. Copyright © 2006 John Wiley & Sons, Ltd.
    Print ISSN: 0885-6087
    Electronic ISSN: 1099-1085
    Topics: Architecture, Civil Engineering, Surveying , Geography
    Published by Wiley
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  • 4
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    A Comparison of Snow Telemetry and Snow Course Measurements in the Colorado River Basin (2006)
    American Meteorological Society
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    Publication Date: 2006-08-01
    Description: Temporal and spatial differences in snow-water equivalent (SWE) at 240 snow telemetry (SNOTEL) and at 500 snow course sites and a subset of 93 collocated sites were evaluated by examining the correlation of site values over the snow season, interpolating point measurements to basin volumes using hypsometry and a maximum snow extent mask, and variogram analysis. The lowest correlation at a point (r = 0.79) and largest interpolated volume differences (as much as 150 mm of SWE over the Gunnison basin) occurred during wet years (e.g., 1993). Interpolation SWE values based on SNOTEL versus snow course sites were not consistently higher or lower relative to each other. Interpolation rmse was comparable for both datasets, increasing later in the snow season. Snow courses correlate over larger distances and have less short-scale variability than SNOTEL sites, making them more regionally representative. Using both datasets in hydrologic models will provide a range of predicted streamflow, which is potentially useful for water resources management.
    Print ISSN: 1525-755X
    Electronic ISSN: 1525-7541
    Topics: Geography , Geosciences , Physics
    Published by American Meteorological Society
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