ISSN:
1432-0703
Source:
Springer Online Journal Archives 1860-2000
Topics:
Energy, Environment Protection, Nuclear Power Engineering
,
Medicine
Notes:
Abstract Photothidiazuron-14C, a major photoconversion product of thidiazuron defoliant on cotton leaves, was rapidly absorbed and eliminated following oral administration to rats. By 96 hr posttreatment, 90.7% of the administered dose was accounted for in the urine (75.5%) and feces (15.2%). Between 5.0 and 10% of the radioactive material in the urine partitioned into ethyl acetate. In addition to photothidiazuron and several unknowns, the following metabolites were present: 4-hydroxyphenylphotothidiazuron, phenylurea, and 4-hydroxyphenylurea. There was also some evidence for the presence of 4-hydroxyacetanilide. The major portion of the radioactivity (〉90%) remained in the urine after extraction with ethyl acetate. Cleavage data withbeta-glucuronidase and aryl sulfatase indicated that at least 12.1% and 6.3%, respectively, of the urinary radioactive materials were conjugated with glucuronic and sulfuric acids. Compounds included 4-hydroxyphenylurea, 4-hydroxyphenylphotothidiazuron, and several unknowns. Fractionation of the feces indicated that about 10% of the radioactive material was organosoluble, about 20% was water soluble and about 70% was unextractable from the fecal residue. Tissue levels of radioactivity were low and in the ppb range.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01055038
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