ISSN:
1432-0886
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Members of the retrotransposon family micropia were discovered as constituents of wild-typeY chromosomal fertility genes fromDrosophila hydei. Several members of the micropia family have subsequently been recovered fromDrosophila melanogaster and four micropia elements, micropia-DhMiF2, -DhMiF8, -Dm11 and-Dm2, two each fromD. hydei andD. melanogaster, have been totally sequenced (17 kb of micropia sequences and 6.8 kb from insertions)1. Comparative analysis of micropia sequences revealed a complex pattern of divergence within a singleDrosophila genome. The divergence includes deletions, possibly by a slipped mispairing mechanism, insertions of a retroposon, and of another retrotransposon (copia) and “positional nucleotide shuffling” within the tandem repeats of the 3′ non-protein-coding region of micropia elements. A 10 bp long sequence of each repeat unit of the 3′ tandem repeats of micropia elements is highly conserved and is therefore a candidate of functional importance either in transposition events or in regulatory activity on flanking DNA sequences.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01735326
Permalink