Publication Date:
1996-03-08
Description:
Haplotypes consisting of alleles at a short tandem repeat polymorphism (STRP) and an Alu deletion polymorphism at the CD4 locus on chromosome 12 were analyzed in more than 1600 individuals sampled from 42 geographically dispersed populations (13 African, 2 Middle Eastern, 7 European, 9 Asian, 3 Pacific, and 8 Amerindian). Sub-Saharan African populations had more haplotypes and exhibited more variability in frequencies of haplotypes than the Northeast African or non-African populations. The Alu deletion was nearly always associated with a single STRP allele in non-African and Northeast African populations but was associated with a wide range of STRP alleles in the sub-Saharan African populations. This global pattern of haplotype variation and linkage disequilibrium suggests a common and recent African origin for all non-African human populations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tishkoff, S A -- Dietzsch, E -- Speed, W -- Pakstis, A J -- Kidd, J R -- Cheung, K -- Bonne-Tamir, B -- Santachiara-Benerecetti, A S -- Moral, P -- Krings, M -- AA09379/AA/NIAAA NIH HHS/ -- HG00348/HG/NHGRI NIH HHS/ -- MH39239/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1996 Mar 8;271(5254):1380-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics, Yale University School of Medicine, New Haven, CT 06520-8005, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8596909" target="_blank"〉PubMed〈/a〉
Keywords:
Africa
;
Alleles
;
Animals
;
Antigens, CD4/*genetics
;
Base Sequence
;
*Chromosomes, Human, Pair 12
;
*Evolution, Molecular
;
Gene Frequency
;
Genetic Variation
;
Haplotypes
;
Hominidae/*genetics
;
Humans
;
*Linkage Disequilibrium
;
Molecular Sequence Data
;
*Polymorphism, Genetic
;
Primates/genetics
;
Repetitive Sequences, Nucleic Acid
;
Sequence Deletion
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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