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  • 1
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    Tuberculous granuloma induction via interaction of a bacterial secreted protein with host epithelium (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-12-17
    Description: Granulomas, organized aggregates of immune cells, are a hallmark of tuberculosis and have traditionally been thought to restrict mycobacterial growth. However, analysis of Mycobacterium marinum in zebrafish has shown that the early granuloma facilitates mycobacterial growth; uninfected macrophages are recruited to the granuloma where they are productively infected by M. marinum. Here, we identified the molecular mechanism by which mycobacteria induce granulomas: The bacterial secreted protein 6-kD early secreted antigenic target (ESAT-6), which has long been implicated in virulence, induced matrix metalloproteinase-9 (MMP9) in epithelial cells neighboring infected macrophages. MMP9 enhanced recruitment of macrophages, which contributed to nascent granuloma maturation and bacterial growth. Disruption of MMP9 function attenuated granuloma formation and bacterial growth. Thus, interception of epithelial MMP9 production could hold promise as a host-targeting tuberculosis therapy.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125975/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125975/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Volkman, Hannah E -- Pozos, Tamara C -- Zheng, John -- Davis, J Muse -- Rawls, John F -- Ramakrishnan, Lalita -- F32 DK062675/DK/NIDDK NIH HHS/ -- F32 DK062675-02/DK/NIDDK NIH HHS/ -- F32 DK062675-03/DK/NIDDK NIH HHS/ -- K01 DK073695/DK/NIDDK NIH HHS/ -- K01 DK073695-01/DK/NIDDK NIH HHS/ -- K01 DK073695-02/DK/NIDDK NIH HHS/ -- K01 DK073695-03/DK/NIDDK NIH HHS/ -- K01 DK073695-04/DK/NIDDK NIH HHS/ -- R01 AI036396/AI/NIAID NIH HHS/ -- R01 AI036396-19/AI/NIAID NIH HHS/ -- R01 AI054503/AI/NIAID NIH HHS/ -- R01 AI054503-09/AI/NIAID NIH HHS/ -- R01 DK081426/DK/NIDDK NIH HHS/ -- R01 DK081426-01/DK/NIDDK NIH HHS/ -- R01 DK081426-02/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2010 Jan 22;327(5964):466-9. doi: 10.1126/science.1179663. Epub 2009 Dec 10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, WA 98155, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20007864" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, Bacterial/genetics/*metabolism ; Bacterial Proteins/genetics/*metabolism ; Disease Models, Animal ; Embryo, Nonmammalian/microbiology ; Enzyme Induction ; Epithelial Cells/*enzymology ; Granuloma/metabolism/*microbiology ; Macrophages/microbiology/physiology ; Matrix Metalloproteinase 9/genetics/*metabolism ; Mycobacterium Infections, Nontuberculous/*microbiology ; Mycobacterium marinum/growth & development/metabolism/*pathogenicity ; Mycobacterium tuberculosis/genetics/pathogenicity ; Oligoribonucleotides, Antisense ; Recombinant Proteins/metabolism ; Tuberculosis/*microbiology ; Virulence Factors/genetics/*metabolism ; Zebrafish/embryology ; Zebrafish Proteins/genetics/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Star formation in nearby early-type galaxies: the radio continuum perspective (2016)
    Oxford University Press
    Details
    Publication Date: 2016-10-22
    Description: We present a 1.4 GHz Karl G. Jansky Very Large Array (VLA) study of a sample of early-type galaxies (ETGs) from the ATLAS 3D survey. The radio morphologies of these ETGs at a resolution of FWHM 5 arcsec include sources that are compact on sub-kpc scales, resolved structures similar to those seen in star-forming spiral galaxies, and kpc-scale radio jets/lobes associated with active nuclei. We compare the radio, CO, and infrared (IR) properties of these ETGs. The most CO-rich ETGs have radio luminosities consistent with extrapolations from H 2 mass derived star-formation rates from studies of late-type galaxies. These ETGs also follow the radio–IR correlation. However, ETGs with lower molecular gas masses tend to have less radio emission relative to their CO and IR emission compared to spirals. The fraction of galaxies in our sample with high IR-radio ratios is much higher than in previous studies, and cannot be explained by a systematic underestimation of the radio luminosity due to the presence extended, low-surface-brightness emission that was resolved out in our VLA observations. We find that the high IR-radio ratios tend to occur at low IR luminosities, but are not associated with low dynamical mass or metallicity. Thus, we have identified a population of ETGs that have a genuine shortfall of radio emission relative to both their IR and CO emission. A number of mechanisms may cause this deficiency, including a bottom-heavy stellar initial mass function, weak magnetic fields, a higher prevalence of environmental effects compared to spirals, and enhanced cosmic ray losses.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Published by Oxford University Press
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  • 3
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    Cocaine plasma concentration: relation to physiological and subjective effects in humans (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-10-13
    Description: Volunteer subjects with previous histories of cocaine use were administered cocaine hydrochloride intravenously or intranasally. There was a positive relationship between peak plasma concentration, physiological and subjective responses, and dose administered. The rate of cocaine disappearance after intravenous administration paralleled the drop in physiological and subjective drug effects. After intranasal administration, blood levels remained elevated for a considerably longer period.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Javaid, J I -- Fischman, M W -- Schuster, C R -- Dekirmenjian, H -- Davis, J M -- New York, N.Y. -- Science. 1978 Oct 13;202(4364):227-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/694530" target="_blank"〉PubMed〈/a〉
    Keywords: Administration, Intranasal ; Cocaine/administration & dosage/*blood/*pharmacology ; Dose-Response Relationship, Drug ; Euphoria/*drug effects ; Heart Rate/drug effects ; Humans ; Injections, Intravenous ; Kinetics ; Metabolic Clearance Rate
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Schizophrenic symptoms improve with apomorphine (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-05
    Description: Eighteen chronic schizophrenic patients received subcutaneous doses of apomorphine, a dopamine receptor agonist, and of placebo in separate trials. A significant improvement in psychotic symptoms occurred after apomorphine compared to placebo. The results are interpreted as a consequence of presynaptic dopamine receptor activation by apomorphine with a subsequent decrease in dopamine-mediated neural transmission.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tamminga, C A -- Schaffer, M H -- Smith, R C -- Davis, J M -- New York, N.Y. -- Science. 1978 May 5;200(4341):567-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/347574" target="_blank"〉PubMed〈/a〉
    Keywords: Apomorphine/pharmacology/*therapeutic use ; Chronic Disease ; Clinical Trials as Topic ; Dose-Response Relationship, Drug ; Double-Blind Method ; Female ; Humans ; Male ; Nerve Endings/drug effects ; Receptors, Dopamine/drug effects ; Schizophrenia/*drug therapy
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Lithium transport across red cell membrane: a cell membrane abnormality in manic-depressive illness (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-31
    Description: In the families of manic-depressive patients, relatives with a history of affective disorders had a significantly higher ratio of mean red cell lithium to plasma lithium in vitro than relatives with no such history. A genetically controlled abnormality in lithium-sodium transport, the mechanism that determines the lithium ratio, may play a role in the etiology of some forms of affective disorders.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dorus, E -- Pandey, G N -- Shaughnessy, R -- Gaviria, M -- Val, E -- Ericksen, S -- Davis, J M -- New York, N.Y. -- Science. 1979 Aug 31;205(4409):932-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472716" target="_blank"〉PubMed〈/a〉
    Keywords: Biological Transport ; Bipolar Disorder/blood/genetics/*metabolism ; Cations, Monovalent/metabolism ; Erythrocyte Membrane/*metabolism ; Erythrocytes/*metabolism ; Humans ; Lithium/*blood ; Pedigree ; Sodium/blood
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Field-Based Approach for Assessing the Impact of Treated Pulp and Paper Mill Effluent on Endogenous Metabolites of Fathead Minnows (Pimephales promelas) (2013)
    American Chemical Society (ACS)
    Details
    Publication Date: 2013-09-01
    Description: Environmental Science & Technology DOI: 10.1021/es401961j
    Print ISSN: 0013-936X
    Electronic ISSN: 1520-5851
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Published by American Chemical Society (ACS)
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  • 7
    Electronic Resource
    Electronic Resource
    ELECTRON-MICROSCOPE STUDIES OF ASBESTOSIS IN MAN AND ANIMALS (1965)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 132 (1965), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1965.tb41093.x
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  • 8
    Electronic Resource
    Electronic Resource
    Geographical distribution of Erwinia salicis strains, the cause of watermark disease of willows (1999)
    Oxford, UK : Blackwell Publishing Ltd
    Forest pathology 29 (1999), S. 0 
    Details
    ISSN: 1439-0329
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Eighty-six isolates of Erwinia salicis, the causal agent of watermark disease of willow, were obtained from culture collections and collected from various willow plantations in south-east England. These isolates were characterized by their reaction in a competitive enzyme-linked immunosorbent assay, by enzyme electrophoresis, and for lysis by a panel of five bacteriophage. Eighty-one isolates had similar characteristics and clustered at a level of similarity of at least 60%. Five isolates were found to have less than 20% similarity to the other E. salicis. Antiserum raised against E. salicis (NCPPB 2535) was found to be specific to E. salicis and did not cross-react with other bacteria tested. No geographical clustering of electrotypes was found: however, Dutch and English isolates could be distinguished by bacteriophage typing. The local distribution of electrotypes collected from diseased trees suggests that the bacterium is spread via the propagating material and that tree to tree spread is rare.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1439-0329.1999.00167.x
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  • 9
    Electronic Resource
    Electronic Resource
    Modeling the Long-Range Transport of Plant Pathogens in the Atmosphere (1987)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Phytopathology 25 (1987), S. 169-188 
    Details
    ISSN: 0066-4286
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.py.25.090187.001125
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  • 10
    Electronic Resource
    Electronic Resource
    Lithium (1971)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Pharmacology 11 (1971), S. 285-302 
    Details
    ISSN: 0362-1642
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.pa.11.040171.001441
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