Publication Date:
1989-12-22
Description:
Fos and Jun form a heterodimeric complex that associates with the nucleotide sequence motif known as the AP-1 binding site. Although this complex has been proposed to function as a transcriptional regulator in neurons, no specific target gene has yet been identified. Proenkephalin mRNA increased in the hippocampus during seizure just after an increase in c-fos and c-jun expression was detected. Fos-Jun complexes bound specifically to a regulatory sequence in the 5' control region of the proenkephalin gene. Furthermore, c-fos and c-jun stimulated transcription from this control region synergistically in transactivation assays. These data suggest that the proenkephalin gene may be a physiological target for Fos and Jun in the hippocampus and indicate that these proto-oncogene transcription factors may play a role in neuronal responses to stimulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sonnenberg, J L -- Rauscher, F J 3rd -- Morgan, J I -- Curran, T -- New York, N.Y. -- Science. 1989 Dec 22;246(4937):1622-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Oncology, Molecular Biology, Roche Research Center, Nutley, NJ 07110.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2512642" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Base Sequence
;
Brain/*metabolism
;
Cell Line
;
DNA-Binding Proteins/*genetics/metabolism
;
Enhancer Elements, Genetic
;
Enkephalins/*genetics
;
*Gene Expression Regulation
;
*Genes
;
Hippocampus/metabolism
;
Mice
;
Molecular Sequence Data
;
Promoter Regions, Genetic
;
Protein Precursors/*genetics
;
Protein-Tyrosine Kinases/*genetics
;
Proto-Oncogene Proteins/*genetics/metabolism
;
Proto-Oncogene Proteins c-fos
;
Proto-Oncogene Proteins c-jun
;
*Proto-Oncogenes
;
RNA, Messenger/genetics
;
Teratoma
;
Transcription Factors/*genetics/metabolism
;
Transcription, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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